Fargesone B | CAS:116424-70-5 | Manufacturer ChemFaces

Fargesone B

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Description:

Fargesone B inhibits the vascular smooth muscle contraction by suppressing the voltage- and receptor-activated calcium influxes in a nonselective manner.

Targets:

Calcium Channel | cAMP

In vivo:

Asia Pacif. J. Pharmacol.,1990,v.5:213-8.

Vasorelaxation of Rat Aorta by Fargesone B Isolated from the Flower buds of Magnolia Fargesii[Reference: WebLink]

The effect of Fargesone B, isolated from Magnolia fargesii, on the contraction of rat aorta was studied.
METHODS AND RESULTS:
Fargesone B suppressed the contraction of aortic rings caused by cumulative concentrations of calcium (0.03-3 mM) in high potassium (60 mM) medium, with an IC50 of 12 .mu.g ml-1. It also relaxed the norepinephrine (NE, 3 .mu.M)-induced contraction, and its pretreatment inhibited both the phasic and tonic contractions elicited by NE, with an IC50 of about 100 and 30 .mu.g ml-1, respectively. This inhibition was also observed in the absence of calcium in the medium. It did not inhibit caffeine-induced phasic contraction. In quin-2-loaded cultured vascular smooth muscle cells, Fargesone B suppressed the rise of intracellular calcium caused by NE but not that by caffeine. 45Ca++ uptake by NE was also concentration-dependently inhibited by Fargesone B. Fargesone B did not change the levels of PGI2, cGMP or cAMP of rat aorta.
CONCLUSIONS:
It is concluded that Fargesone B inhibits the vascular smooth muscle contraction by suppressing the voltage- and receptor-activated calcium influxes in a nonselective

Fargesone B Description

Source:	The flowers of Magnolia fargesii
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Fargesone B
Price:
CAS No.:	116424-70-5
Catalog No.:	CFN96260
Molecular Formula:	C₂₁H₂₄O₆
Molecular Weight:	372.4 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Oil
Source:	The flowers of Magnolia fargesii
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Vasorelaxation Compound Library Lignans Compound Library cAMP Inhibitor Library Calcium Channel Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6853 mL	13.4264 mL	26.8528 mL	53.7057 mL	67.1321 mL
5 mM	0.5371 mL	2.6853 mL	5.3706 mL	10.7411 mL	13.4264 mL
10 mM	0.2685 mL	1.3426 mL	2.6853 mL	5.3706 mL	6.7132 mL
50 mM	0.0537 mL	0.2685 mL	0.5371 mL	1.0741 mL	1.3426 mL
100 mM	0.0269 mL	0.1343 mL	0.2685 mL	0.5371 mL	0.6713 mL

CFN96245	Fargesone A	116424-69-2	372.4	C₂₁H₂₄O₆
CFN96260	Fargesone B	116424-70-5	372.4	C₂₁H₂₄O₆
CFN96289	1,6-Dihydro-4,7'-epoxy-1-methoxy-3',4'-methylenedioxy-6-oxo-3,8'-lignan	67920-48-3	340.4	C₂₀H₂₀O₅
CFN96311	(2S)-2alpha-(1,3-Benzodioxol-5-yl)-3,5-dihydro-5alpha-methoxy-3beta-methyl-5-allyl-2H-benzofuran-6-one	57430-03-2	340.4	C₂₀H₂₀O₅
CFN96250	Kadsurin A	99340-07-5	372.4	C₂₁H₂₄O₆
CFN96283	Piperenone	57625-31-7	388.5	C₂₂H₂₈O₆
CFN96286	Mirandin B	62163-24-0	386.4	C₂₂H₂₆O₆
CFN96386	Burchellin	38276-59-4	340.4	C₂₀H₂₀O₅
CFN96709	3a-Epiburchellin	155551-61-4	340.37	C₂₀H₂₀O₅
CFN96707	2-Epi-3a-epiburchellin	57457-99-5	340.37	C₂₀H₂₀O₅