Gelsemiol | CAS:110414-77-2 | Manufacturer ChemFaces

Gelsemiol

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Description:

Gelsemiol has neurotrophic factor-potentiating activity, markedly enhances an increase in the proportion of neurite-bearing cells and an extension of the neurite length in the presence of nerve growth factor.

Targets:

NGF

In vitro:

J Pharm Pharmacol. 2001 Jun;53(6):915-9.

Potentiation of nerve growth factor-induced elongation of neurites by gelsemiol and 9-hydroxysemperoside aglucone in PC12D cells.[Pubmed: 11428671]

METHODS AND RESULTS:
In PC12D cells, nerve growth factor (NGF) increased the proportion of neurite-bearing cells and made neurites longer. A methanol extract of Verbena littoralis H. B. K. collected in Paraguay only slightly potentiated the proportion of PC12D cells with neurites but markedly increased the length of neurites in the presence of NGF (2 ng mL(-1)). The methanol extract was partitioned between ethyl acetate and water followed by further extraction of water fraction with n-butanol. The potentiating activity of NGF-action was observed in the ethyl acetate and n-butanol fractions. The n-butanol fraction was separated by silica gel chromatography, monitoring the NGF-potentiating activity to give Gelsemiol and 9-hydroxysemperoside aglucone (9-OHSA). Neither compound (30-300 microM) exhibited neurite-inducing activity alone. Gelsemiol (100-300 microM) markedly enhanced an increase in the proportion of neurite-bearing cells and an extension of the neurite length in the presence of NGF (2 ng mL(-1)). Interestingly, in the presence of NGF (2 ng mL(-1)), 9-OHSA (100-300 microM) enhanced the elongation of neurites without affecting the increase in the proportion of cells with neurites.
CONCLUSIONS:
These results suggested that Gelsemiol and 9-OHSA were major active components of V. littoralis in the NGF-potentiating action. It was possible that the mechanism of neurite elongation by NGF was different from that of the increase in the proportion of neurite-bearing cells, and that 9-OHSA selectively affected the neurite elongation mechanism.

Gelsemiol Description

Source:	The herbs of Verbena littoralis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Gelsemiol
Price:
CAS No.:	110414-77-2
Catalog No.:	CFN99205
Molecular Formula:	C₁₀H₁₆O₄
Molecular Weight:	200.2 g/mol
Purity:	>=98%
Type of Compound:	Iridoids
Physical Desc.:	Powder
Source:	The herbs of Verbena littoralis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Neuroprotection Compound Library Iridoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.995 mL	24.975 mL	49.95 mL	99.9001 mL	124.8751 mL
5 mM	0.999 mL	4.995 mL	9.99 mL	19.98 mL	24.975 mL
10 mM	0.4995 mL	2.4975 mL	4.995 mL	9.99 mL	12.4875 mL
50 mM	0.0999 mL	0.4995 mL	0.999 mL	1.998 mL	2.4975 mL
100 mM	0.05 mL	0.2498 mL	0.4995 mL	0.999 mL	1.2488 mL

CFN99205	Gelsemiol	110414-77-2	200.2	C₁₀H₁₆O₄
CFN98272	Borreriagenin	249916-07-2	214.2	C₁₀H₁₄O₅
CFN99467	Asperuloside	14259-45-1	414.4	C₁₈H₂₂O₁₁
CFN92523	Paederoside	20547-45-9	446.4	C₁₈H₂₂O₁₁S
CFN89334	10-O-Coumaroyl-10-O-deacetylasperuloside	903519-82-4	518.47	C₂₅H₂₆O₁₂