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Gitoxin
Gitoxin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Gitoxin
Price:
CAS No.: 4562-36-1
Catalog No.: CFN70364
Molecular Formula: C41H64O14
Molecular Weight: 781.0 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Powder
Source: The herbs of Digitalis lanata
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Gitoxin may offer a potential treatment for drug resistant NSCLC.It inhibited the phosphorylation of Erk1/2 in a dosage and time dependent way.
Targets: ERK
In vitro:
Basic & Clinical Medicine, 2013.
Inhibitory effect of gitoxin on non-small cell lung cancer with gefitinib resistance.[Reference: WebLink]
To evaluate the inhibitory effect of Gitoxin on non small cell lung cancer with drug-resistance in vitro and in vivo and to explore the underlying molecular mechanism.
METHODS AND RESULTS:
Survival and apoptosis rates of H1975 were measured by MTS assay and flow cytometry respectively after Gitoxin and gefitinib treatments.Tumor volumes of Gitoxin treated xenograft nude mice were calculated by measuring the lengths and widths of these tumors.The phosphorylation of Erk1/2 was analyzed by Western blot. Gitoxin inhibited the growth of H1975 and induced its apoptosis more effectively than gefitinib.It also inhibited growth of transplanted tumors in nude mice.In addition,Gitoxin inhibited the phosphorylation of Erk1/2 in a dosage and time dependent way.
CONCLUSIONS:
Gitoxin may offer a potential treatment for drug resistant NSCLC.
Gitoxin Description
Source: The herbs of Digitalis lanata
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.2804 mL 6.402 mL 12.8041 mL 25.6082 mL 32.0102 mL
5 mM 0.2561 mL 1.2804 mL 2.5608 mL 5.1216 mL 6.402 mL
10 mM 0.128 mL 0.6402 mL 1.2804 mL 2.5608 mL 3.201 mL
50 mM 0.0256 mL 0.128 mL 0.2561 mL 0.5122 mL 0.6402 mL
100 mM 0.0128 mL 0.064 mL 0.128 mL 0.2561 mL 0.3201 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Narirutin

Catalog No: CFN99543
CAS No: 14259-46-2
Price: $80/20mg
Neochamaejasmine A

Catalog No: CFN92151
CAS No: 90411-13-5
Price: $418/5mg
Stigmasterol glucoside

Catalog No: CFN98000
CAS No: 19716-26-8
Price: $368/5mg
Paeoniflorin

Catalog No: CFN99544
CAS No: 23180-57-6
Price: $30/20mg
Tricin

Catalog No: CFN98841
CAS No: 520-32-1
Price: $258/10mg
Continentalic acid

Catalog No: CFN90861
CAS No: 19889-23-7
Price: $168/20mg
Tangshenoside I

Catalog No: CFN95108
CAS No: 117278-74-7
Price: $338/10mg
Betulinic acid

Catalog No: CFN98706
CAS No: 472-15-1
Price: $40/20mg
Trigonelline

Catalog No: CFN90225
CAS No: 535-83-1
Price: $40/20mg
Phytol

Catalog No: CFN99630
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Price: $30/20mg
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