Gitoxin | CAS:4562-36-1 | Manufacturer ChemFaces

Gitoxin

ChemFaces products have been cited in many studies from excellent and top scientific journals

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Gitoxin may offer a potential treatment for drug resistant NSCLC.It inhibited the phosphorylation of Erk1/2 in a dosage and time dependent way.

Targets:

ERK

In vitro:

Basic & Clinical Medicine, 2013.

Inhibitory effect of gitoxin on non-small cell lung cancer with gefitinib resistance.[Reference: WebLink]

To evaluate the inhibitory effect of Gitoxin on non small cell lung cancer with drug-resistance in vitro and in vivo and to explore the underlying molecular mechanism.
METHODS AND RESULTS:
Survival and apoptosis rates of H1975 were measured by MTS assay and flow cytometry respectively after Gitoxin and gefitinib treatments.Tumor volumes of Gitoxin treated xenograft nude mice were calculated by measuring the lengths and widths of these tumors.The phosphorylation of Erk1/2 was analyzed by Western blot. Gitoxin inhibited the growth of H1975 and induced its apoptosis more effectively than gefitinib.It also inhibited growth of transplanted tumors in nude mice.In addition,Gitoxin inhibited the phosphorylation of Erk1/2 in a dosage and time dependent way.
CONCLUSIONS:
Gitoxin may offer a potential treatment for drug resistant NSCLC.

Gitoxin Description

Source:	The herbs of Digitalis lanata
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Gitoxin
Price:
CAS No.:	4562-36-1
Catalog No.:	CFN70364
Molecular Formula:	C₄₁H₆₄O₁₄
Molecular Weight:	781.0 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The herbs of Digitalis lanata
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Steroids Compound Library ERK Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2804 mL	6.402 mL	12.8041 mL	25.6082 mL	32.0102 mL
5 mM	0.2561 mL	1.2804 mL	2.5608 mL	5.1216 mL	6.402 mL
10 mM	0.128 mL	0.6402 mL	1.2804 mL	2.5608 mL	3.201 mL
50 mM	0.0256 mL	0.128 mL	0.2561 mL	0.5122 mL	0.6402 mL
100 mM	0.0128 mL	0.064 mL	0.128 mL	0.2561 mL	0.3201 mL

CFN97195	17alpha-Neriifolin	7044-31-7	534.7	C₃₀H₄₆O₈
CFN99868	Odoroside H	18810-25-8	534.7	C₃₀H₄₆O₈
CFN97718	Uzarigenin digitaloside	61217-80-9	534.69	C₃₀H₄₆O₈
CFN98691	Neritaloside	465-13-4	592.7	C₃₂H₄₈O₁₀
CFN98693	Oleandrin	465-16-7	576.7	C₃₂H₄₈O₉
CFN95876	Cryptostigmin II	50906-57-5	740.8	C₃₇H₅₆O₁₅
CFN99245	Thevebioside	114586-47-9	696.8	C₃₆H₅₆O₁₃
CFN99246	17alpha-Thevebioside	114613-59-1	696.8	C₃₆H₅₆O₁₃
CFN70301	Uzarin	20231-81-6	698.8	C₃₅H₅₄O₁₄
CFN96147	Thevetin B	27127-79-3	859.0	C₄₂H₆₆O₁₈