Glaucoside C | CAS:81474-89-7 | Manufacturer ChemFaces

Glaucoside C

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Description:

Anticancer. Glaucoside C was evaluated against the HT-29 and HCT 116 human colon cancer cell lines.

In vitro:

Magn Reson Chem . 2011 Feb;49(2):83-9

Glaucasides A-C, three saikosaponins from Atriplex glauca L. var. ifiniensis (Caball) Maire[Pubmed: 21254229]

From the roots of Atriplex glauca L. var. ifiniensis (Caball) Maire (syn. of Atriplex parvifolia Lowe var. genuina Maire), three new saikosaponins designated as glaucasides A-C (1-3) were isolated together with the known 3-O-β-D-glucopyranosyl-(1 → 2)-β-D-galactopyranosyl-saikogenin F (4). The structures of the new compounds were elucidated by extensive analysis of one-dimensional and two-dimensional NMR spectroscopy, FABMS, HR-ESIMS and chemical evidence as 13β,28-epoxy-16β,21β-dihydroxyolean-11-en-3β-yl O-β-D-[2-O-sulfate]-glucopyranosyl-(1 → 2)-α-L-arabinopyranoside (1), 13β,28-epoxy-16β,21β-dihydroxyolean-11-en-3β-yl O-β-D-[2-O-sulfate]-glucopyranosyl-(1 → 2)-α-L-arabinopyranosyl 21-O-{4-(secbutylamido)-butanoyl ester} (2) and 3-O-β-D-glucopyranosyl-(1 → 2)-β-D-galactopyranosyl saikogenin G (3). The cytotoxic activities of these compounds were evaluated against the HT-29 and HCT 116 human colon cancer cell lines.

Glaucoside C Description

Source:	The roots of Cynanchum stauntonii
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Phytochem Anal . Sep-Oct 2007;18(5):428-35.

Identification and quantification of C21 steroidal saponins from Radix Cynanchi Atrati by high-performance liquid chromatography with evaporative light scattering detection and electrospray mass spectrometric detection[Pubmed: 17624893]

High-performance liquid chromatography coupled with electrospray tandem mass spectrometry (HPLC-ESI/MS) and evaporative light scattering detection (HPLC-ELSD), respectively, has been performed for the simultaneous identification and quantification of six C(21) steroid saponins, including cynanversicoside A, B, D, G, Glaucoside C and glaucogenin C-3-O-beta-d-thevetopyranoside in Radix Cynanchi Atrati. The extraction of the C(21) steroidal saponins was performed using a B-811 Buchi Universal Extraction System in Warm Solvent Mode, and the analyte was concentrated by column chromatography before HPLC analysis. The chromatographic separation was performed on an Agilent Zorbax Extend C(18) analytical column efficiently using gradient elution with acetonitrile and water. The method was validated with acceptable linearities (r > 0.9991) and recoveries (98.2-101.3%). The limits of detection of the C(21) steroid saponins were from 0.2 microg for glaucogenin C-3-O-beta-d-thevetopyranoside to 0.5 microg for cynanversicoside B. The intra- and inter-day precisions of the method were evaluated and were less than 5.0%. The method was successfully used to analyse 20 batches of Radix Cynanchi Atrati. The content of C(21) steroid saponins in the plant material varied significantly from habitat to habitat, confirming the necessity to control the quality of Radix Cynanchi Atrati during its preparation and application in the clinic.

Product Name	Glaucoside C
Price:	$318 / 5mg
CAS No.:	81474-89-7
Catalog No.:	CFN95300
Molecular Formula:	C₄₁H₆₂O₁₅
Molecular Weight:	794.9 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The roots of Cynanchum stauntonii
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Steroids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.258 mL	6.2901 mL	12.5802 mL	25.1604 mL	31.4505 mL
5 mM	0.2516 mL	1.258 mL	2.516 mL	5.0321 mL	6.2901 mL
10 mM	0.1258 mL	0.629 mL	1.258 mL	2.516 mL	3.145 mL
50 mM	0.0252 mL	0.1258 mL	0.2516 mL	0.5032 mL	0.629 mL
100 mM	0.0126 mL	0.0629 mL	0.1258 mL	0.2516 mL	0.3145 mL

CFN89225	Otophylloside B 4'''-O-alpha-L-cymaropyranoside	171422-82-5	1067.31	C₅₆H₉₀O₁₉
CFN89237	Otophylloside B 4'''-O-beta-D-cymaropyranoside	171422-85-8	1067.31	C₅₆H₉₀O₁₉
CFN89226	Otophylloside B 4'''-O-beta-D-oleandropyranoside	168001-54-5	1067.31	C₅₆H₉₀O₁₉
CFN89036	Otophylloside O	1326583-08-7	1077.25	C₅₆H₈₄O₂₀
CFN96784	Cynatratoside A	97399-96-7	504.62	C₂₈H₄₀O₈
CFN96787	Glaucogenin C mono-D-thevetoside	849201-84-9	520.61	C₂₈H₄₀O₉
CFN95299	Glaucoside A	81474-91-1	520.2	C₂₈H₄₀O₉
CFN95300	Glaucoside C	81474-89-7	794.9	C₄₁H₆₂O₁₅
CFN91815	Cynanoside F	1800029-50-8	794.9	C₄₁H₆₂O₁₅
CFN97496	Tenacissoside F	928151-78-4	668.8	C₃₅H₅₆O₁₂