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Glucosamine sulfate
Glucosamine sulfate
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Glucosamine sulfate
Price: $70 / 20mg
CAS No.: 29031-19-4
Catalog No.: CFN99193
Molecular Formula: C6H15NO9S
Molecular Weight: 277.25 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Powder
Source: Present in mucopolysaccharides and in polysaccharides found in bacteria, fungi, higher plants
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $8.9 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Glucosamine sulfate has environmental antibacterial activity. Glucosamine sulfate could as a safe symptomatic Slow Acting Drug for osteoarthritis, it can stimulate proteoglycan synthesis by chondrocytes and has mild anti-inflammatory properties, it is therefore as effective as ibuprofen on symptoms of knee osteoarthritis.
Targets: IL Receptor | MMP(e.g.TIMP) | Antifection
In vitro:
Spine J. 2013 Dec 18. pii: S1529-9430(13)01987-6
The effects of glucosamine sulfate on intervertebral disc annulus fibrosus cells in vitro.[Pubmed: 24361347]
Glucosamine has gained widespread use among patients, despite inconclusive efficacy data. Inconsistency in the clinical literature may be related to lack of understanding of the effects of glucosamine on the intervertebral disc, and therefore, improper patient selection. The goal of our study was to investigate the effects of glucosamine on intervertebral disc cells in vitro under the physiological conditions of inflammation and mechanical loading. Controlled in vitro laboratory setting.
METHODS AND RESULTS:
Intervertebral disc cells isolated from the rabbit annulus fibrosus were exposed to Glucosamine sulfate in the presence and absence of interleukin-1β and tensile strain. Outcome measures included gene expression, measurement of total glycosaminoglycans, new proteoglycan synthesis, prostaglandin E2 production, and matrix metalloproteinase activity. The study was funded by NIH/NCCAM, and the authors have no conflicts of interest. Under conditions of inflammatory stimulation alone, glucosamine demonstrated a dose-dependent effect in decreasing inflammatory and catabolic mediators and increasing anabolic genes. However, under conditions of mechanical stimulation, although inflammatory gene expression was decreased, PGE2 was not. In addition, matrix metalloproteinase-3 gene expression was increased and aggrecan expression decreased, both of which would have a detrimental effect on matrix homeostasis. Consistent with this, measurement of total glycosaminoglycans and new proteoglycan synthesis demonstrated detrimental effects of glucosamine under all conditions tested.
CONCLUSIONS:
These results may in part help to explain the conflicting reports of efficacy, as there is biological plausibility for a therapeutic effect under conditions of predominate inflammation but not under conditions where mechanical loading is present or in which matrix synthesis is needed.
Clin Rheumatol. 2009 Oct;28(10):1221-3.
Glucosamine sulfate--environmental antibacterial activity.[Pubmed: 19495827]
We have recently showed antibacterial activity against E. coli in vitro of a trademark Mega-Gluflex-containing Glucosamine sulfate (GS) and chondroitin sulfate (CS). The purpose of this study was to examine the antibacterial activity of Glucosamine sulfate as a new trademark Arthryl in vitro.
METHODS AND RESULTS:
We used cabbage and chicken broths and milk (every media of 20 ml) left opened for 1 week with and without Arthryl supplements 1,500 mg, the content of one package of the medication. A similar volume (20 ml) is ingested in taking the medication. Experiments with three repeatable results were taken for consideration. Arthryl inhibited environmental bacterial colonies' growth in every media but fungi growth was not impaired. Milk stayed liquid for the whole week with supplement of the Arthryl compared with sour milk transformation without Arthryl. Sample B showed inhibitory properties of the bacterial colonies on the fungi growth. The sample with Arthryl showed progressive growth of fungi without bacterial growth after 10 days of follow up compared with bacterial growth on media without Arthryl. Glucosamine sulfate as a new trademark
CONCLUSIONS:
Arthryl has environmental antibacterial properties but does not inhibit growth of fungal colonies.
In vivo:
Osteoarthritis Cartilage. 1994 Mar;2(1):61-9.
Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.[Pubmed: 11548225]
Glucosamine sulfate is able to stimulate proteoglycan synthesis by chondrocytes and has mild anti-inflammatory properties. In clinical trials, Glucosamine sulfate was more effective than placebo in controlling the symptoms of osteoarthritis (OA).
METHODS AND RESULTS:
In order to better characterize this therapeutic activity, we conducted a randomized, double-blind, parallel-group study of Glucosamine sulfate 500 mg t.i.d. vs ibuprofen 400 mg t.i.d., orally for 4 weeks. The study included 200 hospitalized patients with active OA of the knee, symptoms for at least 3 months and a Lequesne's index of at least 7 points. Patients were evaluated weekly. Response was defined as a reduction in the Lequesne's index by at least 2 points if the enrollment value was higher than 12 points, or by at least 1 point if the enrollment value was 12 or less points, together with a positive overall assessment by the investigator. The improvement tended to be sooner under ibuprofen (48% responders vs 28% after the 1st treatment week; P = 0.06, Fisher's Exact test), but there was no difference from the 2nd week onward, with a success rate of 52% in the ibuprofen group and of 48% in the glucosamine group (P = 0.67) at the end of treatment. The average Lequesne's index at enrollment was around 16 points and decreased by over 6 points in both groups, again with the above described trend. On the other hand, 35% of patients on ibuprofen reported adverse events, mainly of gastrointestinal origin, vs 6% adverse events with glucosamine (P < 0.001, Fisher's Exact test). The number of adverse event related drop-outs was different between the two groups (7% vs 1%, respectively; P = 0.035). Glucosamine sulfate was therefore as effective as ibuprofen on symptoms of knee OA.
CONCLUSIONS:
These data confirm Glucosamine sulfate as a safe symptomatic Slow Acting Drug for OA.
Glucosamine sulfate Description
Source: Present in mucopolysaccharides and in polysaccharides found in bacteria, fungi, higher plants
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.6069 mL 18.0343 mL 36.0685 mL 72.1371 mL 90.1713 mL
5 mM 0.7214 mL 3.6069 mL 7.2137 mL 14.4274 mL 18.0343 mL
10 mM 0.3607 mL 1.8034 mL 3.6069 mL 7.2137 mL 9.0171 mL
50 mM 0.0721 mL 0.3607 mL 0.7214 mL 1.4427 mL 1.8034 mL
100 mM 0.0361 mL 0.1803 mL 0.3607 mL 0.7214 mL 0.9017 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Animal Research:
Ulus Travma Acil Cerrahi Derg. 2013 Jan;19(1):8-12.
Glucosamine-sulfate on fracture healing.[Pubmed: 23588972]
The aim of this study is to determine whether glucosamine-sulfate has any effects on bone-healing.
METHODS AND RESULTS:
A unilateral fracture was created in the tibia of sixty-one female rats. Rats were given no drug or 230 mg/kg glucosamine-sulfate daily. Fractures were analyzed during the first, second and fourth weeks after creation of fracture. Quantitative measurement for new bone formation and osteoblast lining were determined histologically. Semiquantitative score for fracture healing was used for histomorphometric analyses. Bridging bone formation was assessed radiographically. New bone formation and osteoblast lining were significantly higher in glucosamine-treated group at week 1. Surrounding connective tissue was more cellular and vascular, and the newly formed bone trabecules were present in greater amounts in glucosamine-treated group, compared to control group at week 1 and 4. But radiologically, the control group had better scores than that of the glucosamine-treated group at week 4.
CONCLUSIONS:
These data demonstrate that daily glucosamine-sulfate administration accelerates early phase of fracture repair in the rat tibia, with increased new bone formation and osteoblast lining histologically, but radiologic bone union is not favored on radiographs.
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