Glutinone | CAS:508-09-8 | Manufacturer ChemFaces

Glutinone

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Description:

Glutinone (IC50=24 microM) shows a significant effect on thromboxane B2 (TXB2)-release induced by calcium ionophore in human platelets.

Targets:

COX | LOX | PGE

In vitro:

Biol. Pharm. Bul., 2002, 25(1):1-4.

Sesquiterpenes from Jasonia glutinosa: in vitro anti-inflammatory activity.[Pubmed: 11824534]

METHODS AND RESULTS:
Four sesquiterpenes isolated from Jasonia glutinosa D.C. (Asteraceae), namely lucinone, Glutinone, 5-epi-kutdtriol and kutdtriol, have been evaluated for their in vitro anti-inflammatory activity in cellular systems generating cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) metabolites. None of the compounds assayed had a significant effect on leukotriene C4 (LTC4)-release from calcium ionophore-stimulated mouse peritoneal cells. However, the release of prostaglandin E2 (PGE2) by mouse peritoneal cells stimulated with calcium ionophore was inhibited by these compounds, although with less potency than the reference drug indomethacin (IC50=0.24 microM). The IC50 values of the active compounds were: lucinone 42.69 microM, Glutinone 3.61 microM, 5-epi-kutdtriol 1.28 microM and kutdtriol 39 microM.
CONCLUSIONS:
Of the tested compounds, only Glutinone (IC50=24 microM) showed a significant effect on thromboxane B2 (TXB2)-release induced by calcium ionophore in human platelets, although with less potency than the reference drug ibuprofen (IC50=1.27 microM).

Glutinone Description

Source:	The herbs of Eragrostis ferruginea
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Tetrahedron: Asymmetry,2001,12(15):2137–41.

First enantioselective total synthesis of glutinone and its C(7) and C(11) epimers.[Reference: WebLink]

METHODS AND RESULTS:
A facile and efficient asymmetric synthesis of Glutinone 1 and its C(7) and C(11) epimers 1b–d is presented, using the Sharpless asymmetric dihydroxylation reaction as the key step.
CONCLUSIONS:
By comparing the spectral data of the natural product with that of the synthetic samples, we could confirm the absolute configuration of Glutinone 1.

Phytochemistry,1995,40(4):1193–5.

Two sesquiterpenoids, lucinone and glutinone, from Jasonia glutinosa[Reference: WebLink]

METHODS AND RESULTS:
Two new sesquiterpenoids—lucinone (1) and Glutinone (2)—isolated from the aerial parts of Jasonia glutinosa have been characterized by 1D and 2D NMR techniques. The complete structure of these sesquiterpene compounds have been determined as 5β,11,12-trihydroxy-iphionan-4-one and 2-[5′-(2′-oxopentyl)]-2-methyl-5-(1′-hydroxy-1′-methylethanol)-cyclohexanone, respectively.

Product Name	Glutinone
Price:
CAS No.:	508-09-8
Catalog No.:	CFN98802
Molecular Formula:	C₃₀H₄₈O
Molecular Weight:	424.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Eragrostis ferruginea
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-platelet aggregation Compound Library Triterpenoids Compound Library PGE Inhibitor Library LOX Inhibitor Library COX Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3546 mL	11.773 mL	23.546 mL	47.0921 mL	58.8651 mL
5 mM	0.4709 mL	2.3546 mL	4.7092 mL	9.4184 mL	11.773 mL
10 mM	0.2355 mL	1.1773 mL	2.3546 mL	4.7092 mL	5.8865 mL
50 mM	0.0471 mL	0.2355 mL	0.4709 mL	0.9418 mL	1.1773 mL
100 mM	0.0235 mL	0.1177 mL	0.2355 mL	0.4709 mL	0.5887 mL

CFN98911	5-Glutinen-3-ol	545-24-4	426.7	C₃₀H₅₀O
CFN96385	Glutinol acetate	6426-44-4	468.8	C₃₂H₅₂O₂
CFN98802	Glutinone	508-09-8	424.7	C₃₀H₄₈O
CFN90563	Karounidiol	118117-31-0	440.7	C₃₀H₄₈O₂
CFN90562	Bryonolol	39765-50-9	442.7	C₃₀H₅₀O₂
CFN97818	Mupinensisone	152253-67-3	440.71	C₃₀H₄₈O₂
CFN90576	3,29-Dibenzoyl karounitriol	873001-54-8	666.94	C₄₄H₅₈O₅
CFN91175	3,29-O-Dibenzoyloxykarounidiol	389122-01-4	648.9	C₄₄H₅₆O₄
CFN89057	Friedelin 3,4-lactone	29621-75-8	442.72	C₃₀H₅₀O₂