Glycine | CAS:56-40-6 | Manufacturer ChemFaces

Glycine

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Size /Price /Stock	10 mM * 1 mL in DMSO / $5.1 / In-stock
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Description:

Glycine is an inhibitory transmitter, it may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor.

Targets:

NMDA

In vitro:

Nature,1987 Feb 5-11;325(6104):529-31.

Glycine Potentiates the NMDA Response in Cultured Mouse Brain Neurons.[Reference: WebLink]

Transmitters mediating 'fast' synaptic processes in the vertebrate central nervous system are commonly placed in two separate categories that are believed to exhibit no interaction at the receptor level. The 'inhibitory transmitters' (such as Glycine and GABA) are considered to act only on receptors mediating a chloride conductance increase, whereas 'excitatory transmitters' (such as L-glutamate) are considered to activate receptors mediating a cationic conductance increase. The best known excitatory receptor is that specifically activated by N-methyl-D-aspartate (NMDA) which has recently been characterized at the single channel level. The response activated by NMDA agonists is unique in that it exhibits a voltage-dependent Mg block.
METHODS AND RESULTS:
We report here that this response exhibits another remarkable property: it is dramatically potentiated by Glycine. This potentiation is not mediated by the inhibitory strychnine-sensitive Glycine receptor, and is detected at a Glycine concentration as low as 10 nM. The potentiation can be observed in outside-out patches as an increase in the frequency of opening of the channels activated by NMDA agonists.
CONCLUSIONS:
Thus, in addition to its role as an inhibitory transmitter, Glycine may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor.

Glycine Description

Source:	The seeds of Glycine max (Linn.) Merr.）
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Glycine
Price:	$30 / 20mg
CAS No.:	56-40-6
Catalog No.:	CFN70144
Molecular Formula:	C₂H₅NO₂
Molecular Weight:	75.0 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Oil
Source:	The seeds of Glycine max (Linn.) Merr.）
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	13.3333 mL	66.6667 mL	133.3333 mL	266.6667 mL	333.3333 mL
5 mM	2.6667 mL	13.3333 mL	26.6667 mL	53.3333 mL	66.6667 mL
10 mM	1.3333 mL	6.6667 mL	13.3333 mL	26.6667 mL	33.3333 mL
50 mM	0.2667 mL	1.3333 mL	2.6667 mL	5.3333 mL	6.6667 mL
100 mM	0.1333 mL	0.6667 mL	1.3333 mL	2.6667 mL	3.3333 mL

CFN00478	18-Hydroxyspartioidine	N/A	349.4	C₁₈H₂₃NO₆
CFN96938	3-Epichromolaenide	89913-53-1	404.45	C₂₂H₂₈O₇
CFN90398	Siamenoside I	126105-12-2	1125.29	C₅₄H₉₂O₂₄
CFN90651	Hederagenin 28-O-beta-D-glucopyranosyl ester	53931-25-2	634.9	C₃₆H₅₈O₉