Glycinol | CAS:69393-95-9 | Manufacturer ChemFaces

Glycinol

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $278.6 / In-stock
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Description:

Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells, it could as a potential preventive or treatment for osteoporosis. Glycinol also has antidiuretic activity.

In vitro:

Regen Med. 2017 Jul;12(5):513-524.

Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells.[Pubmed: 28718749 ]

Phytoestrogens, such as Glycinol, have recently gained significant attention as an alternative therapy for osteoporosis due to their structural similarity to estradiol and their bone-generating potential.
METHODS AND RESULTS:
The osteogenic effects of Glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older (>50 years old) and younger subjects (<25 years old). BMSCs isolated from older donors demonstrated reduced osteogenesis. 17β-estradiol and Glycinol exposure rescued the age-related reduction in osteogenic differentiation of BMSCs. These results correlated with the induction of osteogenic genes and estrogen receptor-α (ER-α) following Glycinol treatment. ER antagonist studies further support that Glycinol promotes osteogenesis through ER signaling.
CONCLUSIONS:
The results from these studies support investigating Glycinol as a potential preventive or treatment for osteoporosis.

In vivo:

Eksp Klin Farmakol. 2010 Oct;73(10):21-4.

[Influence of new neurohypophyseal hormone analogs on sodium and water reabsorption in rat kidney].[Pubmed: 21254509]

New analogs of some neurohypophyseal hormones (oxypressin, hydrin, glumitocin, vasotocin) have been synthesized.
METHODS AND RESULTS:
Experiments with injection of these peptides to rats showed that substitution of C-terminal glycinamide on beta-ethanolamine (Glycinol) or ethylamine in 1-deamino-arginine vasotocin resulted in loss of natriuretic but not antidiuretic activity.
CONCLUSIONS:
Analogs of oxypressin and hydrin exhibited neither natriuretic activity nor ability to affect water reabsorption. Glumitocin analog induced renal sodium ion excretion and did not influence potassium ion excretion.

Glycinol Description

Source:	The herbs of Derris robusta
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Glycinol
Price:	$398 / 5mg
CAS No.:	69393-95-9
Catalog No.:	CFN95122
Molecular Formula:	C₁₅H₁₂O₅
Molecular Weight:	272.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The herbs of Derris robusta
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.6724 mL	18.3621 mL	36.7242 mL	73.4484 mL	91.8105 mL
5 mM	0.7345 mL	3.6724 mL	7.3448 mL	14.6897 mL	18.3621 mL
10 mM	0.3672 mL	1.8362 mL	3.6724 mL	7.3448 mL	9.1811 mL
50 mM	0.0734 mL	0.3672 mL	0.7345 mL	1.469 mL	1.8362 mL
100 mM	0.0367 mL	0.1836 mL	0.3672 mL	0.7345 mL	0.9181 mL

CFN97945	(-)-Variabilin	370102-93-5	300.3	C₁₇H₁₆O₅
CFN90838	Methylnissolin	73340-41-7	300.3	C₁₇H₁₆O₅
CFN93199	Methylnissolin-3-O-glucoside	94367-42-7	462.5	C₂₃H₂₆O₁₀
CFN96063	3-Hydroxy-8,9-methylenedioxypterocarpene	59901-98-3	282.3	C₁₆H₁₀O₅
CFN99746	Maackiain	19908-48-6	284.27	C₁₆H₁₂O₅
CFN97160	Trifolirhizin	6807-83-6	446.4	C₂₂H₂₂O₁₀
CFN96037	6alpha-Hydroxymaackiain	61218-44-8	300.3	C₁₆H₁₂O₆
CFN96000	Pisatin	20186-22-5	314.3	C₁₇H₁₄O₆
CFN96672	Sophoracarpan A	1674359-82-0	300.31	C₁₇H₁₆O₅
CFN96671	Sophoracarpan B	1674359-84-2	314.30	C₁₇H₁₄O₆