Science | Nature | Cell | View More
Natural Products
Glycyrrhisoflavone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Glycyrrhisoflavone
Price: $318 / 10mg
CAS No.: 116709-70-7
Catalog No.: CFN90817
Molecular Formula: C20H18O6
Molecular Weight: 354.4 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The roots of Glycyrrhiza uralensis Fisch.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $164.6 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • National Chung Hsing University (Taiwan)
  • Florida International University (USA)
  • Guangzhou Institutes of Biomedi... (China)
  • Kitasato University (Japan)
  • Donald Danforth Plant Science C... (USA)
  • Istanbul University (Turkey)
  • Griffith University (Australia)
  • University of Vienna (Austria)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Institute of Bioorganic Chemist... (Poland)
  • University of Limpopo (South Africa)
  • More...
Package
Featured Products
Oxypeucedanin

Catalog No: CFN90350
CAS No: 737-52-0
Price: $80/20mg
3,4-Dihydroxybenzoic acid

Catalog No: CFN97568
CAS No: 99-50-3
Price: $30/20mg
Robinin

Catalog No: CFN98375
CAS No: 301-19-9
Price: $318/5mg
Trilobatin

Catalog No: CFN98658
CAS No: 4192-90-9
Price: $30/20mg
Estragole

Catalog No: CFN70065
CAS No: 140-67-0
Price: $30/20mg
Erigoster B

Catalog No: CFN93294
CAS No: 849777-61-3
Price: $ / mg
Vitexin

Catalog No: CFN98601
CAS No: 3681-93-4
Price: $60/20mg
Ginkgolic acid C13:0

Catalog No: CFN98507
CAS No: 20261-38-5
Price: $168/20mg
Silybin A

Catalog No: CFN95149
CAS No: 22888-70-6
Price: $318/20mg
Croceic acid

Catalog No: CFN90226
CAS No: 27876-94-4
Price: $60/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Glycyrrhisoflavone is a tyrosinase inhibitor, it also shows inhibitory effects on monoamine oxidase. Glycybenzofuran shows significant protein tyrosine phosphatase-1B (PTP1B) inhibitory activity in vitro with the IC50 value of 25.5 microM. Glycyrrhisoflavone has anti-inflammatory effects, it has significant inhibitory effects against NO production on LPS-induced RAW 264.7 cell model.
Targets: NO | MAO | Tyrosinase
In vitro:
Sci Rep. 2016 Aug 8;6:31000.
Rapid discovery and identification of anti-inflammatory constituents from traditional Chinese medicine formula by activity index, LC-MS, and NMR.[Pubmed: 27499135 ]
The traditional activity-guided approach has the shortcoming of low accuracy and efficiency in discovering active compounds from TCM.
METHODS AND RESULTS:
In this work, an approach was developed by integrating activity index (AI), liquid chromatography - mass spectrometry (LC-MS), and nuclear magnetic resonance (NMR) to rapidly predict and identify the potential active constituents from TCM. This approach was used to discover and identify the anti-inflammatory constituents from a TCM formula, Gui-Zhi-Jia-Shao-Yao-Tang (GZJSYT). The AI results indicated that, among the 903 constituents detected in GZJSYT by LC-MS, 61 constituents with higher AI values were very likely to have anti-inflammatory activities. And eight potential active constituents of them were isolated and validated to have significant inhibitory effects against NO production on LPS-induced RAW 264.7 cell model. Among them, Glycyrrhisoflavone (836), glisoflavanone (893) and isoangustone A (902) were reported to have anti-inflammatory effects for the first time.
CONCLUSIONS:
The proposed approach could be generally applicable for rapid and high efficient discovery of anti-inflammatory constituents from other TCM formulae or natural products.
Glycyrrhisoflavone Description
Source: The roots of Glycyrrhiza uralensis Fisch.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Hydroxytyrosol 1-O-glucoside

Catalog No: CFN95367
CAS No: 76873-99-9
Price: $318/10mg
1,3,6-Trihydroxy-2-methylanthraqui...

Catalog No: CFN95096
CAS No: 87686-88-2
Price: $318/10mg
Rhamnocitrin 3-glucoside

Catalog No: CFN95134
CAS No: 41545-37-3
Price: $318/10mg
Polygalasaponin XXXV

Catalog No: CFN95176
CAS No: 184479-28-5
Price: $463/5mg
Ginsenoside MC

Catalog No: CFN95232
CAS No: 175484-06-7
Price: $318/10mg
Securoside A

Catalog No: CFN95294
CAS No: 107172-40-7
Price: $318/5mg
Isolappaol A

Catalog No: CFN95224
CAS No: 131400-96-9
Price: $333/10mg
Gynosaponin TN2

Catalog No: CFN95331
CAS No: 77658-95-8
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8217 mL 14.1084 mL 28.2167 mL 56.4334 mL 70.5418 mL
5 mM 0.5643 mL 2.8217 mL 5.6433 mL 11.2867 mL 14.1084 mL
10 mM 0.2822 mL 1.4108 mL 2.8217 mL 5.6433 mL 7.0542 mL
50 mM 0.0564 mL 0.2822 mL 0.5643 mL 1.1287 mL 1.4108 mL
100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.5643 mL 0.7054 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Bioorg Med Chem Lett. 2010 Sep 15;20(18):5398-401
Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities.[Pubmed: 20724155 ]

METHODS AND RESULTS:
Two new 2-arylbenzofurans, glycybenzofuran (1) and cyclolicocoumarone (2), together with 10 known flavonoids including licocoumarone (3), Glycyrrhisoflavone (4), glisoflavone (5), cycloGlycyrrhisoflavone (6), isoliquiritigenin (7), licoflavone A (8), apigenin (9), isokaempferide (10), glycycoumarin (11), and isoglycycoumarin (12), were isolated from the roots of Glycyrrhiza uralensis and their structures were determined by extensive spectroscopic analyses. Compounds 1 and 5 showed significant protein tyrosine phosphatase-1B (PTP1B) inhibitory activity in vitro with the IC50 values of 25.5 and 27.9 microM, respectively. The structure-activity relationship indicated that the presence of prenyl group and ortho-hydroxy group is important for exhibiting the activity.
CONCLUSIONS:
Kinetic analysis indicated that compound 1 inhibits PTP1B by a competitive mode, whereas compound 5 by a mixed mode.
Planta Med. 2005 Aug;71(8):785-7.
Identification of tyrosinase inhibitors from Glycyrrhiza uralensis.[Pubmed: 16142649]
Tyrosinase is a key enzyme in the production of melanins.
METHODS AND RESULTS:
Phytochemical studies of a Glycyrrhiza uralensis extract were performed by measuring the tyrosinase and melanin synthesis inhibitory activity. Glycyrrhisoflavone and glyasperin C were identified as tyrosinase inhibitors for the first time. Glyasperin C showed a stronger tyrosinase inhibitory activity (IC (50) = 0.13 +/- 0.01 microg/mL) than glabridin (IC (50) = 0.25 +/- 0.01 microg/mL) and a moderate inhibition of melanin production (17.65 +/- 8.8 % at 5 microg/mL). Glycyrrhisoflavone showed a strong melanin synthesis inhibitory activity (63.73 +/- 6.8 % inhibition at 5 microg/mL).
CONCLUSIONS:
These results suggest that glyasperin C and Glycyrrhisoflavone could be promising candidates in the design of skin-whitening agents.
Chem Pharm Bull (Tokyo). 1991 May;39(5):1238-43.
Phenolic constituents of licorice. III. Structures of glicoricone and licofuranone, and inhibitory effects of licorice constituents on monoamine oxidase.[Pubmed: 1913999]
Two new phenolic compounds, glicoricone (3) and licofuranone (4), were isolated from a species of licorice brought from the northwestern region of China, and their structures were assigned.
METHODS AND RESULTS:
Among the twelve licorice constituents examined for the inhibition of monoamine oxidase (MAO), six compounds, 3, 4, genistein (6), licopyranocoumarin (7), licocoumarone (14) and Glycyrrhisoflavone (15), inhibited the enzyme with the IC50 (concentration required for 50% inhibition of the enzyme activity) values of 6.0 x 10(-5)-1.4 x 10(-4) M. Glycyrrhizin (1) also inhibited MAO with the IC50 value of 1.6 x 10(-4) M.
Oxypeucedanin

Catalog No: CFN90350
CAS No: 737-52-0
Price: $80/20mg
3,4-Dihydroxybenzoic acid

Catalog No: CFN97568
CAS No: 99-50-3
Price: $30/20mg
Robinin

Catalog No: CFN98375
CAS No: 301-19-9
Price: $318/5mg
Trilobatin

Catalog No: CFN98658
CAS No: 4192-90-9
Price: $30/20mg
Estragole

Catalog No: CFN70065
CAS No: 140-67-0
Price: $30/20mg
Erigoster B

Catalog No: CFN93294
CAS No: 849777-61-3
Price: $ / mg
Vitexin

Catalog No: CFN98601
CAS No: 3681-93-4
Price: $60/20mg
Ginkgolic acid C13:0

Catalog No: CFN98507
CAS No: 20261-38-5
Price: $168/20mg
Silybin A

Catalog No: CFN95149
CAS No: 22888-70-6
Price: $318/20mg
Croceic acid

Catalog No: CFN90226
CAS No: 27876-94-4
Price: $60/20mg
Tags: buy Glycyrrhisoflavone | Glycyrrhisoflavone supplier | purchase Glycyrrhisoflavone | Glycyrrhisoflavone cost | Glycyrrhisoflavone manufacturer | order Glycyrrhisoflavone | Glycyrrhisoflavone distributor