Gosferol | CAS:37551-62-5 | Manufacturer ChemFaces

Gosferol

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In vitro:

Pharm Biol . 2014 Dec;52(12):1543-1549.

Antiviral and cytotoxic evaluation of coumarins from Prangos ferulacea[Pubmed: 25026335]

Context: Prangos ferulacea (L.) Lindl. (Apiaceae) is a perennial plant found in the Middle-East, where it is commonly used as an antispasmodic and anti-inflammatory agent. It is a rich source of coumarins. Objective: To purify several coumarins from P. ferulacea and to screen their cytotoxicity and anti-herpes activity. Materials and methods: Acetone extract of roots of P. ferulacea was subjected to several chromatographic separations to render pure coumarins (1-8). Anti-herpes virus effects of 1-7 were evaluated at concentration 2.5, 5, and 10 μgmL(-1), on a confluent monolayer of Vero cells infected with 25 PFU of HSV1. Cytotoxic effects of 1 and 2 were evaluated on an A2780S cell line using the MTT assay. The cells were exposed to a series of concentrations of coumarins (0.01-2.5 mM, 37°C, 72 h). Results: Compounds 1-8 were identified as osthole, isoimperatorin, oxypeucedanin, psoralen, oxypeucedanin hydrate, Gosferol, oxypeucedanin methnolate, and pranferol. This is the first report of occurrence of 4 and 7 in this plant. Compound 1 showed a viability of 9.41% ± 2.4 at 2.5 mM on A2780S cells (IC50 = 0.38 mM). The cell survival of 2 at 2.5 mM was 46.86% ± 5.5 with IC50 equal to 1.1 mM. Discussion and conclusion: Compound 1 shows cytotoxic effects on the A2780S cell line. Compound 2 is a cyclooxygenase-2 inhibitor and the A2780S cell line does not express COX-2 which may interpret the non-toxic effect of the compound on this cell line. None of the tested compounds showed an anti-HSV effect at non-toxic concentrations.

Gosferol Description

Source:	The roots of Heracleum repula
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Gosferol
Price:
CAS No.:	37551-62-5
Catalog No.:	CFN91699
Molecular Formula:	C₁₆H₁₄O₅
Molecular Weight:	286.3 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The roots of Heracleum repula
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Coumarins Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.4928 mL	17.4642 mL	34.9284 mL	69.8568 mL	87.321 mL
5 mM	0.6986 mL	3.4928 mL	6.9857 mL	13.9714 mL	17.4642 mL
10 mM	0.3493 mL	1.7464 mL	3.4928 mL	6.9857 mL	8.7321 mL
50 mM	0.0699 mL	0.3493 mL	0.6986 mL	1.3971 mL	1.7464 mL
100 mM	0.0349 mL	0.1746 mL	0.3493 mL	0.6986 mL	0.8732 mL

CFN92021	Przewaquinone C	96839-29-1	296.3	C₁₈H₁₆O₄
CFN60133	PD184352 (CI-1040)	212631-79-3	478.67	C₁₇H₁₄ClF₂IN₂O₂
CFN97238	3-Epikatonic acid	76035-62-6	456.7	C₃₀H₄₈O₃
CFN98988	N-(2-Hydroxy-4-methoxyphenyl)acetamide	58469-06-0	181.2	C₉H₁₁NO₃