7-Epitaxol | CAS:105454-04-4 | Manufacturer ChemFaces

7-Epitaxol

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Description:

7-Epitaxol is the major derivative of taxol found in cells and taxol (paclitaxel) is a well-known natural-source cancer drug.

In vitro:

J Pharmacol Exp Ther. 1987 Aug;242(2):692-8.

Taxol is converted to 7-epitaxol, a biologically active isomer, in cell culture medium.[Pubmed: 2886648]

The hydrolysis products of taxol have been isolated by high-performance liquid chromatography and identified by nuclear magnetic resonance and mass spectroscopy. In contrast to taxol, the major hydrolysis product, baccatin III, has little cytotoxic activity and does not promote in vitro microtubule assembly.
METHODS AND RESULTS:
In cell culture medium, the concentration of taxol decreases with time and 7-Epitaxol, which exhibits properties comparable to those of taxol both on cells and on in vitro microtubuli polymerization, is formed. Baccatin III is found in small quantities in the cell medium, although it is barely detectable within the cells.
CONCLUSIONS:
It is concluded that 7-Epitaxol is the major derivative of taxol found in cells and that its presence does not alter, in a major way, the overall biological activity of taxol.

7-Epitaxol Description

Source:	The barks of Taxus chinensis (Pilger) Rehd.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Anticancer Agents Med Chem. 2015;15(3):400-5.

Mesenchymal stromal cells uptake and release paclitaxel without reducing its anticancer activity.[Pubmed: 24942547]

To improve the drug delivery efficiency on target cells, many strategies have been developed including Mesenchymal Stromal Cells (MSCs) approaches. In a previous study, we found that bone-marrow-derived MSCs (BM-MSCs) were able to incorporate and release the anti-tumor and anti-angiogenic drug, Paclitaxel (PTX).
METHODS AND RESULTS:
In this study, we evaluated the stability of PTX in standard cell culture conditions by analyzing the metabolites produced by MSCs after their incorporation of the drug. We are able to show that MSCs do not release either 3-OH-PTX or 6-OH-PTX metabolites (having a lower anticancer activity) but release an active PTX molecule together with the isomer 7-Epitaxol, is known to maintain the whole biological activity.
CONCLUSIONS:
This confirms that the simple procedure of MSCs priming with a drug (without any genetic cell manipulation), in our case PTX, does not modify the activity of the molecule and provides a new biological-device to carry and deliver PTX in tumor sites, by contributing to improve drug efficacy and target selectivity in cancer therapy.

Product Name	7-Epitaxol
Price:	$60 / 20mg
CAS No.:	105454-04-4
Catalog No.:	CFN90371
Molecular Formula:	C₄₇H₅₁NO₁₄
Molecular Weight:	853.91 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The barks of Taxus chinensis (Pilger) Rehd.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.1711 mL	5.8554 mL	11.7108 mL	23.4217 mL	29.2771 mL
5 mM	0.2342 mL	1.1711 mL	2.3422 mL	4.6843 mL	5.8554 mL
10 mM	0.1171 mL	0.5855 mL	1.1711 mL	2.3422 mL	2.9277 mL
50 mM	0.0234 mL	0.1171 mL	0.2342 mL	0.4684 mL	0.5855 mL
100 mM	0.0117 mL	0.0586 mL	0.1171 mL	0.2342 mL	0.2928 mL

CFN89044	13-O-Cinnamoylbaccatin III	220932-65-0	716.77	C₄₀H₄₄O₁₂
CFN89140	Cabazitaxel intermediate	1354900-65-4	926.02	C₅₁H₅₉NO₁₅
CFN98517	Docetaxel	114977-28-5	807.88	C₄₃H₅₃NO₁₄
CFN98516	N-Debenzoyl-N-(tert-butoxycarbonyl)taxol	125354-16-7	849.92	C₄₅H₅₅NO₁₅
CFN98518	Cephalomannine	71610-00-9	831.91	C₄₅H₅₃NO₁₄
CFN90687	Deacetyltaxol	78432-77-6	811.87	C₄₅H₄₉NO₁₃
CFN90371	7-Epitaxol	105454-04-4	853.91	C₄₇H₅₁NO₁₄
CFN97759	Paclitaxel	33069-62-4	853.92	C₄₇H₅₁NO₁₄
CFN98515	7-Xylosyltaxol	90332-66-4	986.0	C₅₂H₅₉NO₁₈
CFN90837	10-Deacetyl-7-xylosyl paclitaxel	90332-63-1	944.0	C₅₀H₅₇NO₁₇