Grosvenorin | CAS:156980-60-8 | Manufacturer ChemFaces

Grosvenorin

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $101.5 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Grosvenorine exhibits good antibacterial and antioxidant activities, with its metabolites possessing more potent activities, intestinal bacteria play an important role in the gastrointestinal metabolism of grosvenorine and significantly affect its pharmacological activities.

Targets:

Antifection

In vitro:

Chem Biodivers. 2015 Nov;12(11):1652-64.

The Gastrointestinal Tract Metabolism and Pharmacological Activities of Grosvenorine, a Major and Characteristic Flavonoid in the Fruits of Siraitia grosvenorii.[Pubmed: 26567944 ]

Grosvenorine is the major flavonoid compound of the fruits of Siraitia grosvenorii (Swingle) C. Jeffrey, a medical plant endemic to China.
METHODS AND RESULTS:
In the present study, for the first time, the Grosvenorine metabolism in an in vitro simulated human gastrointestinal tract (including artificial gastric juice, artificial intestinal juice and intestinal flora), as well as its pharmacological activities (including anti-complement, antibacterial and antioxidant activities), was investigated. The results showed that Grosvenorine was metabolized by human intestinal flora; its four metabolites were isolated by semi-preparative HPLC and identified by NMR as kaempferitrin, afzelin, α-rhamnoisorobin, and kaempferol. Further pharmacological evaluation showed that Grosvenorine exhibited good antibacterial and antioxidant activities, with its metabolites possessing more potent activities. Although Grosvenorine did not present obvious anticomplement activity, its metabolites showed interesting activities.
CONCLUSIONS:
This study revealed that intestinal bacteria play an important role in the gastrointestinal metabolism of Grosvenorine and significantly affect its pharmacological activities.

Grosvenorin Description

Source:	The fruits of Siraitia grosuenorii
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Grosvenorin
Price:	$188 / 10mg
CAS No.:	156980-60-8
Catalog No.:	CFN99772
Molecular Formula:	C₃₃H₄₀O₁₉
Molecular Weight:	740.7 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The fruits of Siraitia grosuenorii
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Antibacterial Compound Library Flavonoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3501 mL	6.7504 mL	13.5007 mL	27.0015 mL	33.7519 mL
5 mM	0.27 mL	1.3501 mL	2.7001 mL	5.4003 mL	6.7504 mL
10 mM	0.135 mL	0.675 mL	1.3501 mL	2.7001 mL	3.3752 mL
50 mM	0.027 mL	0.135 mL	0.27 mL	0.54 mL	0.675 mL
100 mM	0.0135 mL	0.0675 mL	0.135 mL	0.27 mL	0.3375 mL

CFN92630	5-Methoxy-7-hydroxycoumarin	3067-10-5	192.2	C₁₀H₈O₄
CFN93346	Neochebulagic acid	28196-46-5	972.67	C₄₁H₃₂O₂₈
CFN70467	8-Acetyl-7-methoxycoumarin	89019-07-8	218.2	C₁₂H₁₀O₄
CFN89164	Pyracrenic acid	80832-44-6	618.85	C₃₉H₅₄O₆