Handelin | CAS:62687-22-3 | Manufacturer ChemFaces

Handelin

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.

Targets:

NO | PGE | TNF-α | IL Receptor | NF-kB | MAPK | ERK | JNK | IkB | IKK

In vitro:

Planta Med 2012; 78 - PD86.

Request full-text Anti-inflammatory activity of handelin through the modulation of NF-κB signaling and pro-inflammatory cytokine productions[Reference: WebLink]

Handelin, a guaianolide dimer, is a constituent of the flower of Chrysanthemum boreale Makino (Compositae). C. boreale have been used as traditional medicines for the treatment of vertigo and fever in Asian countries.
METHODS AND RESULTS:
The present study was designed to investigate the anti-inflammatory potential of Handelin in vitro and in vivo. Handelin inhibited LPS-stimulated production of NO and PGE2 in cultured mouse macrophage RAW 264.7 cells. The suppression of NO and PGE2 production by Handelin was correlated with the down-regulation of mRNA and protein expressions of iNOS and COX-2. Further study revealed that Handelin suppressed the induction of pro-inflammatory cytokines including TNF-α and IL-1β as well as microRNA-155 in LPS-induced RAW264.7 cells. Activation of the transcriptional activity of NF-κB by LPS was also alleviated by Handelin, which was well coincided with its inhibitory effect on IκB degradation. In addition, the activation of MAPKs such as ERK and JNK signaling was suppressed by Handelin. In in vivo animal model, oral administration of Handelin inhibited carrageenan-induced paw edema and TPA-induced ear edema, respectively. The analysis of cytokine production in serum showed that Handelin dose-dependently inhibited the production of IL-1β in a carrageenan-induced paw edema.
CONCLUSIONS:
These findings suggest that Handelin might be an active ingredient of C. boreale with the anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.

Handelin Description

Source:	The herbs of Dendranthema indicum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Handelin
Price:
CAS No.:	62687-22-3
Catalog No.:	CFN90906
Molecular Formula:	C₃₂H₄₀O₈
Molecular Weight:	552.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Dendranthema indicum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Triterpenoids Compound Library TNF-α Inhibitor Library PGE Inhibitor Library NO Inhibitor Library NF-kB Inhibitor Library MAPK Inhibitor Library JNK Inhibitor Library IL Receptor Inhibitor Library IKK Inhibitor Library IkB Inhibitor Library ERK Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8093 mL	9.0465 mL	18.093 mL	36.186 mL	45.2325 mL
5 mM	0.3619 mL	1.8093 mL	3.6186 mL	7.2372 mL	9.0465 mL
10 mM	0.1809 mL	0.9046 mL	1.8093 mL	3.6186 mL	4.5232 mL
50 mM	0.0362 mL	0.1809 mL	0.3619 mL	0.7237 mL	0.9046 mL
100 mM	0.0181 mL	0.0905 mL	0.1809 mL	0.3619 mL	0.4523 mL

CFN92708	Japonicone D	1078711-42-8	596.7	C₃₄H₄₄O₉
CFN92801	Inulanolide A	888941-86-4	596.7	C₃₄H₄₄O₉
CFN90168	Absinthiin	1362-42-1	496.62	C₃₀H₄₀O₆
CFN90906	Handelin	62687-22-3	552.7	C₃₂H₄₀O₈
CFN99048	Pre-schisanartanin B	1033288-92-4	590.7	C₃₁H₄₂O₁₁