Herpetone | CAS:951677-22-8 | Manufacturer ChemFaces

Herpetone

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Description:

Herpetone exhibits protective effects on CCl(4)-induced hepatocyte injury, it shows anti-hepatitis B virus (HBV) activity.

Targets:

HBV

In vitro:

Molecules. 2016 Dec 27;22(1). pii: E14.

Anti-HBV Activities of Three Compounds Extracted and Purified from Herpetospermum Seeds.[Pubmed: 28035986 ]

The goal of this research was to evaluate the anti-hepatitis B virus (HBV) activities of three compounds extracted and purified from Herpetospermum seeds (HS) on HepG2.2.15 cells.
METHODS AND RESULTS:
Herpetin (HPT), Herpetone (HPO), and herpetfluorenone (HPF) were isolated from HS and identified using HR-ESI-MS and NMR. Different concentrations of the drugs were added to the HepG2.2.15 cells. Cell toxicity was observed with an MTT assay, cell culture supernatants were collected, and HBsAg and HBeAg were detected by ELISA. The content of HBV DNA was determined via quantitative polymerase chain reaction (PCR) with fluorescent probes. The 50% toxicity concentration (TC50) of HPF was 531.48 μg/mL, suggesting that this species is less toxic than HPT and HPO.
CONCLUSIONS:
HPT and HPF showed more potent antiviral activities than HPO. The 50% inhibition concentration (IC50) values of HPF on HBsAg and HBeAg were 176.99 and 134.53 μg/mL, respectively, and the corresponding therapeutic index (TI) values were 2.66 and 3.49, respectively. HPT and HPF were shown to significantly reduce the level of HBV DNA in the HepG2.2.15 culture medium compared to the negative control. This initial investigation of the anti-HBV constituents of HS yielded three compounds that revealed a synergistic effect of multiple components in the ethnopharmacological use of HS.

Herpetone Description

Source:	The fruits of Herpetospermum pedunculosum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Chem Pharm Bull (Tokyo). 2008 Feb;56(2):192-3.

Two new coumarins from Herpetospermum caudigerum.[Pubmed: 18239307]

METHODS AND RESULTS:
The ethyl acetate extract from the seeds of Herpetospermum caudigerum was found to show protective effects on carbon tetrachloride (CCl(4)) and thioacetamide (TAA)-induced acute hepatic injuries in mice. From the ethyl acetate extract, two new coumarins, herpetolide A (1) and herpetolide B (2), along with four known compounds, Herpetone (3), dehydrodiconiferyl alcohol (4), 2,4-dihydroxypyrimidine (5) and stigmasterol (6) were isolated.
CONCLUSIONS:
The structures of the new coumarins were elucidated on the basis of chemical and physicochemical evidences. Herpetone exhibited protective effects on CCl(4)-induced hepatocyte injury.

Product Name	Herpetone
Price:	$368 / 5mg
CAS No.:	951677-22-8
Catalog No.:	CFN90676
Molecular Formula:	C₂₉H₃₀O₉
Molecular Weight:	522.54 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The fruits of Herpetospermum pedunculosum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Hepatoprotective Compound Library Antiviral Compound Library Lignans Compound Library HBV Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9137 mL	9.5686 mL	19.1373 mL	38.2746 mL	47.8432 mL
5 mM	0.3827 mL	1.9137 mL	3.8275 mL	7.6549 mL	9.5686 mL
10 mM	0.1914 mL	0.9569 mL	1.9137 mL	3.8275 mL	4.7843 mL
50 mM	0.0383 mL	0.1914 mL	0.3827 mL	0.7655 mL	0.9569 mL
100 mM	0.0191 mL	0.0957 mL	0.1914 mL	0.3827 mL	0.4784 mL

CFN98775	Pinoresinol	487-36-5	358.4	C₂₀H₂₂O₆
CFN90879	Pinoresinol dimethyl ether	29106-36-3	386.4	C₂₂H₂₆O₆
CFN96266	Eudesmin	526-06-7	386.4	C₂₂H₂₆O₆
CFN96935	3,4,5'-Trimethoxy-3',4'-methylenedioxy-7,9':7',9-diepoxylignan	873867-94-8	400.42	C₂₂H₂₄O₇
CFN98420	Pinoresinol diacetate	32971-25-8	442.5	C₂₄H₂₆O₈
CFN97180	Pinoresinol 4-O-beta-D-glucopyranoside	69251-96-3	520.5	C₂₆H₃₂O₁₁
CFN80044	Epipinoresinol-4-O-beta-D-glucoside	24404-49-7	520.52	C₂₆H₃₂O₁₁
CFN99994	Pinoresinol diglucoside	63902-38-5	682.67	C₃₂H₄₂O₁₆
CFN95356	8-Hydroxypinoresinol-4'-O-beta-D-glucopyranoside	102582-69-4	536.5	C₂₆H₃₂O₁₂
CFN95083	8-Hydroxypinoresinol diglucoside	112747-99-6	698.7	C₃₂H₄₂O₁₇