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Icariside E5
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Icariside E5
Price:
CAS No.: 126176-79-2
Catalog No.: CFN99373
Molecular Formula: C26H34O11
Molecular Weight: 522.6 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The herbs of Epimedium brevicornu
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Icariside E5 may have antioxidant property that strengthen the importance of peppers in the Mediterranean diet.
In vitro:
J Agric Food Chem. 2001 Apr;49(4):2022-9.
New glycosides from Capsicum annuum L. var. acuminatum. Isolation, structure determination, and biological activity.[Pubmed: 11308362]
Investigation of polar extracts from ripe fruits of Capsicum annuum L. var. acuminatum yielded three new glycosides, capsosides A (1) and B (2) and capsianoside VII (3), along with seven known compounds (4-10).
METHODS AND RESULTS:
The chemical structures were elucidated mainly by extensive nuclear magnetic resonance methods and mass spectrometry, and the biological activities of icariside E(5) (4) were tested by different assays. Icariside E(5), in contrast to capsaicin, neither induces an increase in the intracellular levels of reactive oxygen species nor affects the mitochondria permeability transition, and it does not signal through the vanilloid receptor type 1. Interestingly, this compound protects Jurkat cells from apoptosis induced by the oxidative stress mediated by serum withdrawal.
CONCLUSIONS:
These results suggest that icariside E(5) may have antioxidant properties that strengthen the importance of peppers in the Mediterranean diet.
Icariside E5 Description
Source: The herbs of Epimedium brevicornu
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9135 mL 9.5675 mL 19.1351 mL 38.2702 mL 47.8377 mL
5 mM 0.3827 mL 1.9135 mL 3.827 mL 7.654 mL 9.5675 mL
10 mM 0.1914 mL 0.9568 mL 1.9135 mL 3.827 mL 4.7838 mL
50 mM 0.0383 mL 0.1914 mL 0.3827 mL 0.7654 mL 0.9568 mL
100 mM 0.0191 mL 0.0957 mL 0.1914 mL 0.3827 mL 0.4784 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Biochemical Systematics and Ecology,2008,36(12): 915–918.
Flavonoid glycosides and phenolic acids from Ehretia thyrsiflora[Reference: WebLink]

METHODS AND RESULTS:
Twelve compounds including six flavonoids and six phenolic acids, isoquercetrin, hyperoside, trifolin, astragalin, kaempferol 3-O-arabinosylgalactoside, quercetin 3-O-arabinosylgalactoside, rosmarinic acid, cinnamic acid, Icariside E5, ferulic acid, α-hydroxydihydrocaffeic acid, lithospermic acid B were first isolated from this species.
CONCLUSIONS:
The considerable phenolic compounds existed in this species have important systematic significance in the argument of the family the Boraginaceae.
Epimedin B

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CAS No: 110623-73-9
Price: $128/20mg
Tannic acid

Catalog No: CFN90501
CAS No: 1401-55-4
Price: $40/20mg
Chebulagic acid

Catalog No: CFN92295
CAS No: 23094-71-5
Price: $ / mg
Bavachin

Catalog No: CFN98007
CAS No: 19879-32-4
Price: $40/20mg
5-O-Methylvisammioside

Catalog No: CFN98106
CAS No: 84272-85-5
Price: $50/20mg
Deoxypodophyllotoxin

Catalog No: CFN99888
CAS No: 19186-35-7
Price: $268/10mg
Euphorbia factor L2

Catalog No: CFN92884
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Ampelopsin

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