Ikarisoside F | CAS:113558-14-8 | Manufacturer ChemFaces

Ikarisoside F

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Ikarisoside F and epimedin A can bind to AdoHcy hydrolase, inhibit the activity of AdoHcy hydrolase, thus regulating the cellular biomethylation as well as reducing cellular Hcy level.

In vitro:

Life Sci. 2005 Nov 26;78(2):180-6.

Inhibitory effect of Epimedium extract on S-adenosyl-L-homocysteine hydrolase and biomethylation.[Pubmed: 16125732]

In the present paper, the inhibitory effect of Epimedium extract on the activity of S-adenosyl-L-homocysteine (AdoHcy) Hydrolase was studied.
METHODS AND RESULTS:
The results showed that Epimedium extract inhibited the activity of recombinant human AdoHcy hydrolase in a dose-dependent manner. This inhibitory effect was also observed in hepatic cell line 7701 and hepatoma HepG2, however, the effect in 7701 cells was more potent than in HepG2 cells. The extract could significantly reduce AdoMet/AdoHcy ratio in 7701 cells in a dose-dependent manner, suggesting reduced biomethylation level in 7701 cells. In contrast, it resulted in elevated AdoMet/AdoHcy ratio in the HepG2 cells. The result of MALDI-MS assay indicated that epimedin A and Ikarisoside F from the extract could bind to AdoHcy hydrolase. The present data suggested that Epimedium extract could inhibit the activity of AdoHcy hydrolase, thus regulating the cellular biomethylation as well as reducing cellular Hcy level.
CONCLUSIONS:
These results will provide new clues to the mechanisms of Epimedium in curing of cardiovascular disease and regulating tumor cell growth.

Ikarisoside F Description

Source:	The roots of Epimedium brevicornu Maxim
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Ikarisoside F
Price:
CAS No.:	113558-14-8
Catalog No.:	CFN90138
Molecular Formula:	C₃₁H₃₆O₁₄
Molecular Weight:	632.62 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The roots of Epimedium brevicornu Maxim
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5807 mL	7.9036 mL	15.8073 mL	31.6146 mL	39.5182 mL
5 mM	0.3161 mL	1.5807 mL	3.1615 mL	6.3229 mL	7.9036 mL
10 mM	0.1581 mL	0.7904 mL	1.5807 mL	3.1615 mL	3.9518 mL
50 mM	0.0316 mL	0.1581 mL	0.3161 mL	0.6323 mL	0.7904 mL
100 mM	0.0158 mL	0.079 mL	0.1581 mL	0.3161 mL	0.3952 mL

CFN91155	Iso-sagittatoside A	503456-08-4	676.7	C₃₃H₄₀O₁₅
CFN92905	Korepimedoside A	106441-31-0	760.74	C₃₇H₄₄O₁₇
CFN90765	Baohuoside VII	119730-89-1	676.7	C₃₃H₄₀O₁₅
CFN99554	Icariin	489-32-7	676.65	C₃₃H₄₀O₁₅
CFN99940	Epimedin B	110623-73-9	808.78	C₃₈H₄₈O₁₉
CFN95017	Epimedin B1	133137-58-3	808.8	C₃₈H₄₈O₁₉
CFN91887	Maohuoside B	849834-04-4	838.80	C₃₉H₅₀O₂₀
CFN99941	Epimedin C	110642-44-9	822.80	C₃₉H₅₀O₁₉
CFN99145	Epimedin A1	140147-77-9	838.8	C₃₉H₅₀O₂₀
CFN99939	Epimedin A	110623-72-8	838.80	C₃₉H₅₀O₂₀