Integerrimine | CAS:480-79-5 | Manufacturer ChemFaces

Integerrimine

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Integerrimine

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Description:

Prenatal exposure to Integerrimine N-oxide induces maternal toxicity, impairment of maternal care and delayed in physical and behavioral development of the offspring. Doses of Integerrimine N-oxide here employed did not produce marked immunotoxic effects.

In vivo:

Food Chem Toxicol. 2011 Sep;49(9):2313-9.

Haematological and immunological effects of repeated dose exposure of rats to integerrimine N-oxide from Senecio brasiliensis.[Pubmed: 21722699]

This study is the first in the literature to focus attention on the possible immunotoxic effect of Integerrimine N-oxide content in the butanolic residue (BR) of Senecio brasiliensis, a poisonous hepatotoxic plant that contains pyrrolizidine alkaloids (PAs). PAs have been reported as a pasture and food contaminant and as herbal medicine used worldwide and are responsible for poisoning events in livestock and human beings.
METHODS AND RESULTS:
After the plant extraction, BR extracted from Senecio brasiliensis was found to contain approximately 70% Integerrimine N-oxide by elemental and spectral analyses ((1)H and (13)C NMR), which was administered to adult male Wistar Hannover rats at doses of 3, 6 and 9 mg/kg for 28 days. Our study showed that Integerrimine N-oxide could promote an impairment in the body weight gain, interference with blood cell counts and a reducing T cell proliferative activity in rats; however, no differences in the neutrophil activities, lymphocytes phenotyping and humoural and cellular immune responses were observed.
CONCLUSIONS:
It is concluded that doses of Integerrimine N-oxide here employed did not produce marked immunotoxic effects.

Integerrimine Description

Source:	The herbs of Senecio scandens Buch.-Ham. ex D. Don
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Int J Dev Neurosci. 2014 Aug;36:53-63.

Prenatal exposure to integerrimine N-oxide impaired the maternal care and the physical and behavioral development of offspring rats.[Pubmed: 24881561]

The aim of this present study was to evaluate effects of prenatal exposure to Integerrimine N-oxide, the main PA found in the butanolic residue (BR) of Senecio brasiliensis, on both physical and behavioral parameters of Wistar rat offspring. The toxicity and maternal behavior were also evaluated.
METHODS AND RESULTS:
For this, pregnant Wistar rats received Integerrimine N-oxide from the BR of Senecio brasiliensis, by gavage, on gestational days 6-20 (during organogenesis and fetal development period) at doses of 3, 6 and 9 mg/kg. Results showed that prenatal exposure to Integerrimine N-oxide of S. brasiliensis induced maternal toxicity, impairment in maternal behavior and aggressive maternal behavior, mainly in the highest dose group.
CONCLUSIONS:
Thus, prenatal exposure to Integerrimine N-oxide induces maternal toxicity, impairment of maternal care and delayed in physical and behavioral development of the offspring.

Product Name	Integerrimine
Price:
CAS No.:	480-79-5
Catalog No.:	CFN00419
Molecular Formula:	C₁₈H₂₅NO₅
Molecular Weight:	335.40 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Senecio scandens Buch.-Ham. ex D. Don
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-mitotic Compound Library Genotoxicity Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9815 mL	14.9076 mL	29.8151 mL	59.6303 mL	74.5379 mL
5 mM	0.5963 mL	2.9815 mL	5.963 mL	11.9261 mL	14.9076 mL
10 mM	0.2982 mL	1.4908 mL	2.9815 mL	5.963 mL	7.4538 mL
50 mM	0.0596 mL	0.2982 mL	0.5963 mL	1.1926 mL	1.4908 mL
100 mM	0.0298 mL	0.1491 mL	0.2982 mL	0.5963 mL	0.7454 mL

CFN00417	Senecionine	130-01-8	335.40	C₁₈H₂₅NO₅
CFN00419	Integerrimine	480-79-5	335.40	C₁₈H₂₅NO₅
CFN00458	Integerrimine N-oxide	85955-28-8	351.4	C₁₈H₂₅NO₆
CFN00373	Gynuramine	85611-43-4	351.40	C₁₈H₂₅NO₆
CFN00374	Hastacine	20361-77-7	337.41	C₁₈H₂₇NO₅
CFN00388	Nilgirine	21009-05-2	321.37	C₁₇H₂₃NO₅
CFN00389	Crotastriatine	11051-94-8	363.41	C₁₉H₂₅NO₆
CFN00403	Platyphylline	480-78-4	337.41	C₁₈H₂₇NO₅
CFN00404	Hygrophylline	3573-82-8	353.41	C₁₈H₂₇NO₆
CFN00405	Ligularinine	90364-90-2	337.41	C₁₈H₂₇NO₅