Isocolumbin | CAS:471-54-5 | Manufacturer ChemFaces

Isocolumbin

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Description:

Isocolumbin has anti-inflammatory, and antimicrobial activities.

Targets:

Antifection | Immunology & Inflammation related

In vivo:

J Ethnopharmacol. 2006 Mar 8;104(1-2):87-91.

Anti-inflammatory activities of the methanol extracts and an isolated furanoditerpene constituent of Sphenocentrum jollyanum Pierre (Menispermaceae).[Pubmed: 16236477]

METHODS AND RESULTS:
Sphenocentrum jollyanum crude extracts and an isolated constituent were evaluated for anti-inflammatory activity using the carrageenan-induced hind paw oedema of healthy adult albino rats and utilizing the oral route of administration. The fruit methanol extract (79.58% inhibition at 200 mg kg(-1)) gave a higher anti-inflammatory activity than the root extract (53.75% inhibition at 200 mg ml(-1)). Further purification of the most active fruit methanol extract (MFE) led to the isolation of three furanoditerpenes identified as columbin, Isocolumbin, fibleucin (uv, ir, nmr and ms) as well as a flavonoid-rich fraction (FDE). Both columbin (67.08% inhibition at 20 mg kg(-1), p<0.05) and FDE (76.25% inhibition at 200 mg kg(-1); p<0.05) gave significant anti-inflammatory activities in comparable range with reference acetylsalicylic acid (72.5% inhibition at 100 mg kg(-1)).
CONCLUSIONS:
The results provide some justification for the folkloric uses of Sphenocentrum jollyanum in the treatment of inflammatory-based diseases across the West African sub-region.

Isocolumbin Description

Source:	The roots of Stephania tetrandra S.Moore
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Journal of Chinese Pharmaceutical Sciences, 2010,45(10):733-5.

Chemical constituents and antimicrobial effect of Tinospora sagittata (Oliv.) Gagnep.[Reference: WebLink]

To study chemical constituents and antimicrobial effect of Tinosporae sagittata (Oliv.) Gagnep.
METHODS AND RESULTS:
The compounds were isolated from ethanol extraction and purified by MCI, Rp-8, silica gel column chromatograph. The structures of the compounds were determined by physicochemical properties and the spectrum analysis (TLC, MS, 1H-NMR, 13C-NMR). The antimicrobial abilities of the five compounds were determined by colorimetry. Five compounds were separated from Tinospora sagittata and were identified as columbin (I), Isocolumbin (II), jatrorrhizine (III), tinoside (IV) and palmatine (V). The antimicrobial activity of palmatine was the strongest, jatrorrhizine was relatively weak.
CONCLUSIONS:
The compound I-V all were isolated from WuDang Tinosporae sagittata (Oliv.) Gagnep. for the first time.

Product Name	Isocolumbin
Price:
CAS No.:	471-54-5
Catalog No.:	CFN98538
Molecular Formula:	C₂₀H₂₂O₆
Molecular Weight:	358.39 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The roots of Stephania tetrandra S.Moore
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Antibacterial Compound Library Diterpenoids Compound Library Immunology & Inflammation related Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7903 mL	13.9513 mL	27.9026 mL	55.8051 mL	69.7564 mL
5 mM	0.5581 mL	2.7903 mL	5.5805 mL	11.161 mL	13.9513 mL
10 mM	0.279 mL	1.3951 mL	2.7903 mL	5.5805 mL	6.9756 mL
50 mM	0.0558 mL	0.279 mL	0.5581 mL	1.1161 mL	1.3951 mL
100 mM	0.0279 mL	0.1395 mL	0.279 mL	0.5581 mL	0.6976 mL

CFN97799	Hautriwaic acid	18411-75-1	332.44	C₂₀H₂₈O₄
CFN89305	Dehydrohautriwaic acid	51905-84-1	330.42	C₂₀H₂₆O₄
CFN97754	Methyl dodonate A	349534-70-9	344.45	C₂₁H₂₈O₄
CFN97755	Methyl dodonate A acetate	349487-98-5	386.49	C₂₃H₃₀O₅
CFN90480	Columbin	546-97-4	358.39	C₂₀H₂₂O₆
CFN98538	Isocolumbin	471-54-5	358.39	C₂₀H₂₂O₆
CFN90388	Levatin	140670-84-4	328.36	C₁₉H₂₀O₅
CFN90375	Croverin	76475-17-7	370.40	C₂₁H₂₂O₆
CFN90374	Crovatin	142409-09-4	374.43	C₂₁H₂₆O₆
CFN96616	Tinospinoside C	1383977-51-2	552.58	C₂₇H₃₆O₁₂