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Isodictamnine
Isodictamnine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Isodictamnine
Price:
CAS No.: 484-74-2
Catalog No.: CFN96762
Molecular Formula: C12H9NO2
Molecular Weight: 199.20 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The roots of Dictamnus angustifolius G. Don.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Isodictamnine is phototoxic to certain bacteria and yeasts in long wave UV light.
In vitro:
Planta Med. 1981 Feb;41(2):136-42.
Phototoxic furanoquinolines of the Rutaceae.[Reference: WebLink]

METHODS AND RESULTS:
Dictamnine, Isodictamnine, 7-demethylskimmianine, maculosidine and maculine were shown to be phototoxic to certain bacteria and yeasts in long wave UV light. Dose response curves with dictamnine and 8-methoxypsoralen in UV light were compared using E. COLI and SACCHAROMYCES CEREVISIAE.
CONCLUSIONS:
In comparison with 8-methoxypsoralen higher concentrations of dictamnine are required to elicit a phototoxic response.
Isodictamnine Description
Source: The roots of Dictamnus angustifolius G. Don.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.0201 mL 25.1004 mL 50.2008 mL 100.4016 mL 125.502 mL
5 mM 1.004 mL 5.0201 mL 10.0402 mL 20.0803 mL 25.1004 mL
10 mM 0.502 mL 2.51 mL 5.0201 mL 10.0402 mL 12.5502 mL
50 mM 0.1004 mL 0.502 mL 1.004 mL 2.008 mL 2.51 mL
100 mM 0.0502 mL 0.251 mL 0.502 mL 1.004 mL 1.255 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chemistry of Natural Compounds, 1978, 14(4):404-406.
The roots of Dictamnus angustifolius.[Reference: WebLink]

METHODS AND RESULTS:
From the roots of Dictamnus angustifolius G. Don. collected in Chimgan at the end-of-fruit-bearing stage have been isolated alkaloids dictamnine, skimmianine, γ-fagarine, Isodictamnine, isopteleine, and preskimmianine, the limonoid fraxinellone, and the steroid β-sitosterol.
CONCLUSIONS:
This is the first time that any of these substances, with the exception of dictamnine and skimmianine, have been found in this plant.
CFN98858gamma-Fagarine524-15-2229.2 C13H11NO3
CFN95126Maculosidin522-19-0259.3C14H13NO4
CFN96010Haplopine5876-17-5245.2C13H11NO4
CFN92555Skimmianin83-95-4259.3C14H13NO4
CFN982427-Isopentenyloxy-gamma-fagarine23417-92-7313.4 C18H19NO4
CFN90488Evodine6989-38-4329.35C18H19NO5
CFN98849Evoxine522-11-2347.4 C18H21NO6
CFN96762Isodictamnine484-74-2199.20C12H9NO2
CFN96763Isopteleine2181-84-2229.23C13H11NO3
CFN96765Isomaculosidine518-96-7259.26C14H13NO4
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