Isoscopoletin | CAS:776-86-3 | Manufacturer ChemFaces

Isoscopoletin

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $13.9 / In-stock
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Description:

Isoscopoletin possesses inhibitory activity against hepatitis B virus (HBV) replication; it also shows substantial inhibition against multi-drug resistant CEM/ADR5000 cells and human CCRF-CEM leukaemia cells, with the IC50 value is 1.6 and 4.0 microM, respectively.

Targets:

HBV

In vitro:

Planta Med. 2006 Jul;72(9):862-4.

Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi.[Pubmed: 16881019]

METHODS AND RESULTS:
The ethyl acetate extract of Artemisia argyi leaves showed substantial inhibition in a cell proliferation assay using human CCRF-CEM leukaemia cells. Bioassay-guided fractionation of the extract led to the isolation of scopoletin and Isoscopoletin as the active principles. Their IC50 values were 2.6 and 4.0 microM, respectively. Additionally the two substances were tested against the multidrug resistant subline, CEM/ADR5000 where they both showed IC50 values of 1.6 microM.
CONCLUSIONS:
In contrast to the standard cytostatic drugs doxorubicin, vincristine, and paclitaxel, CEM/ADR5000 cells therefore did not exhibit cross-resistance to scopoletin and Isoscopoletin.

Planta Med. 2005 Dec;71(12):1128-33.

Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus.[Pubmed: 16395649 ]

METHODS AND RESULTS:
Nineteen compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus were tested for inhibitory effects on hepatitis B virus (HBV) and Herpes simplex virus type-1 (HSV-1). The results showed that apigenin 4'- O- alpha-rhamnopyranoside, apigenin 7- O- beta-glucopyranosyl-4'- O- alpha-rhamnopyranoside, tricin 7- O- beta-glucopyranoside, tricin, and Isoscopoletin possessed inhibitory activity against HBV replication. Protocatechuyl aldehyde exhibited an inhibiting activity on HSV-1 replication.
CONCLUSIONS:
It is therefore suggested that further investigations on these bioactive compounds might be needed to discover and develop new antiviral agents.

Isoscopoletin Description

Source:	The herbs of Paederia scandens (Lour.) Merr
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Isoscopoletin
Price:	$70 / 20mg
CAS No.:	776-86-3
Catalog No.:	CFN97684
Molecular Formula:	C₁₀H₈O₄
Molecular Weight:	192.17 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The herbs of Paederia scandens (Lour.) Merr
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antiviral Compound Library Antileukaemic Compound Library Anti-multidrug resistance Compound Library Coumarins Compound Library HBV Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.2037 mL	26.0186 mL	52.0373 mL	104.0745 mL	130.0931 mL
5 mM	1.0407 mL	5.2037 mL	10.4075 mL	20.8149 mL	26.0186 mL
10 mM	0.5204 mL	2.6019 mL	5.2037 mL	10.4075 mL	13.0093 mL
50 mM	0.1041 mL	0.5204 mL	1.0407 mL	2.0815 mL	2.6019 mL
100 mM	0.052 mL	0.2602 mL	0.5204 mL	1.0407 mL	1.3009 mL

CFN80132	Daphnin	486-55-5	340.3	C₁₅H₁₆O₉
CFN90593	Daphnetin 7-methyl ether	19492-03-6	192.17	C₁₀H₈O₄
CFN89148	Hydrangetin	485-90-5	192.17	C₁₀H₈O₄
CFN90594	Daphnetin dimethyl ether	2445-80-9	206.19	C₁₁H₁₀O₄
CFN93089	4-Methyldaphnetin	2107-77-9	192.17	C₁₀H₈O₄
CFN91402	7-Methoxy-8-hydroxy-4-methylcoumarin	22084-94-2	206.2	C₁₁H₁₀O₄
CFN93090	5,7-Dihydroxy-4-methylcoumarin	2107-76-8	192.17	C₁₀H₈O₄
CFN99115	6,7-Dihydroxycoumarin	305-01-1	178.14	C₉H₆O₄
CFN93058	4-Methylesculetin	529-84-0	192.17	C₁₀H₈O₄
CFN99114	Esculin	531-75-9	340.28	C₁₅H₁₆O₉