Isotanshinone IIA | CAS:20958-15-0 | Manufacturer ChemFaces

Isotanshinone IIA

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Isotanshinone IIA Description

Source:	The roots of Salvia miltiorrhiza Bge.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Biol Pharm Bull. 2005 Sep;28(9):1795-7.

PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza.[Pubmed: 16141564]

Protein tyrosine phosphatase 1B (PTP1B) acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes.
METHODS AND RESULTS:
In the course of screening for PTP1B inhibitory natural products, the MeOH extract of the dried root of Salvia miltiorrhiza BUNGE (Labiatae) was found to exhibit significant inhibitory effect. Bioassay-guided fractionation and purification afforded three related abietane-type diterpene metabolites 1-3. Compounds 1-3 were identified as Isotanshinone IIA (1), dihydroisotanshinone I (2), and isocryptotanshinone (3) mainly by analysis of NMR and MS data.
CONCLUSIONS:
Compounds 1-3 non-competitively inhibited PTP1B activity with 50% inhibitory concentration values of 11.4+/-0.6 microM, 22.4+/-0.6 microM and 56.1+/-6.3 microM, respectively.

Product Name	Isotanshinone IIA
Price:
CAS No.:	20958-15-0
Catalog No.:	CFN90357
Molecular Formula:	C₁₉H₁₈O₃
Molecular Weight:	294.35 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Red powder
Source:	The roots of Salvia miltiorrhiza Bge.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Diterpenoids Compound Library

Description:	Isotanshinone IIA non-competitively inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 11.4±0.6 μM. PTP1B acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes.
Targets:	PTP1B

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3973 mL	16.9866 mL	33.9732 mL	67.9463 mL	84.9329 mL
5 mM	0.6795 mL	3.3973 mL	6.7946 mL	13.5893 mL	16.9866 mL
10 mM	0.3397 mL	1.6987 mL	3.3973 mL	6.7946 mL	8.4933 mL
50 mM	0.0679 mL	0.3397 mL	0.6795 mL	1.3589 mL	1.6987 mL
100 mM	0.034 mL	0.1699 mL	0.3397 mL	0.6795 mL	0.8493 mL

CFN90327	Danshenxinkun C	65907-77-9	252.3	C₁₆H₁₂O₃
CFN90326	Danshenxinkun B	65907-76-8	280.3	C₁₈H₁₆O₃
CFN90325	Danshenxinkun A	65907-75-7	296.32	C₁₈H₁₆O₄
CFN90328	Danshenxinkun D	98873-76-8	336.38	C₂₁H₂₀O₄
CFN90162	Dihydroisotanshinone I	20958-18-3	278.30	C₁₈H₁₄O₃
CFN90355	Isocryptotanshinone	22550-15-8	296.36	C₁₉H₂₀O₃
CFN90356	Isotanshinone I	20958-17-2	276.29	C₁₈H₁₂O₃
CFN90357	Isotanshinone IIA	20958-15-0	294.35	C₁₉H₁₈O₃