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Kalopanaxsaponin H
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Kalopanaxsaponin H
Price: $318 / 5mg
CAS No.: 128730-82-5
Catalog No.: CFN90430
Molecular Formula: C47H76O17
Molecular Weight: 913.09 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The herbs of Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $381.5 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Kalopanaxsaponin H has antidiabetic activity.
In vitro:
Biol Pharm Bull. 1998 Apr;21(4):360-5.
Metabolism of kalopanaxsaponin B and H by human intestinal bacteria and antidiabetic activity of their metabolites.[Pubmed: 9586573]
To investigate the relationship between the intestinal bacterial metabolism of kalopanaxsaponin B and Kalopanaxsaponin H from Kalopanax pictus (Araliaceae), and their antidiabetic effect, kalopanaxsaponin B and Kalopanaxsaponin H were metabolized by human intestinal microflora and the antidiabetic activity of their metabolites was measured.
METHODS AND RESULTS:
Kalopanaxsaponin H was metabolized to kalopanaxsaponin A and I, hederagenin 3-O-alpha-L-arabinopyranoside and hederagenin. The main metabolites of Kalopanaxsaponin H were kalopanaxsaponin I and hederagenin. Among kalopanaxsaponin B, H and their metabolites, kalopanaxsaponin A showed the most potent antidiabetic activity, followed by hederagenin. However, the main components, kalopanaxsaponin B and Kalopanaxsaponin H, in K. pictus were inactive.
Biol Pharm Bull. 2002 Jan;25(1):68-71.
Metabolism of kalopanaxsaponin K by human intestinal bacteria and antirheumatoid arthritis activity of their metabolites.[Pubmed: 11824560]

METHODS AND RESULTS:
When kalopanaxsaponin K (KPK) from Kalopanax pictus was incubated for 24 h at 37 degrees C with human intestinal microflora, KPK was mainly metabolized to kalopanaxsaponin I (KPI) via Kalopanaxsaponin H (KPH) rather than via kalopanaxsaponin J (KPJ), and then transformed to kalopanaxsaponin A (KPA) and hederagenin. Bacteroides sp., and Bifidobacterium sp. and Fusobacterium sp. transformed KPK to KPI and KPA and hederagenin via Kalopanaxsaponin H or KPJ. However, Lactobacillus sp. and Streptococcus sp. transformed KPK to KPI, KPA, and hederagenin only via KPJ.
CONCLUSIONS:
The metabolite KPA of KPK showed potent antirheumatoid arthritis activity.
Kalopanaxsaponin H Description
Source: The herbs of Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

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doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

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IF=13.903(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.0952 mL 5.4759 mL 10.9518 mL 21.9036 mL 27.3796 mL
5 mM 0.219 mL 1.0952 mL 2.1904 mL 4.3807 mL 5.4759 mL
10 mM 0.1095 mL 0.5476 mL 1.0952 mL 2.1904 mL 2.738 mL
50 mM 0.0219 mL 0.1095 mL 0.219 mL 0.4381 mL 0.5476 mL
100 mM 0.011 mL 0.0548 mL 0.1095 mL 0.219 mL 0.2738 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Cell Research:
Planta Med. 2000 May;66(4):329-32.
Essential moiety for antimutagenic and cytotoxic activity of hederagenin monodesmosides and bisdesmosides isolated from the stem bark of Kalopanax pictus.[Pubmed: 10865448 ]
For the elucidation of the antimutagenic and cytotoxic principles from the stem bark of Kalopanax pictus, seven isolated components of this crude drug were tested in the Ames test and the MTT test.
METHODS AND RESULTS:
Hederagenin and its monodesmosides, kalopanaxsaponin A and kalopanaxsaponin I in addition to its bisdesmosides, kalopanaxsaponin B and Kalopanaxsaponin H, showed potent antimutagenic activities against aflatoxin B1 (AFB1). However, they had no inhibitory effects on mutagenicity induced by the direct mutagen, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). This suggested that hederagenin glycosides might effectively prevent the metabolic activation of AFB1 or scavenge the electrophilic intermediate capable of inducing mutation. Hederagenin was found to be an essential moiety for the exhibition of antimutagenicity. Moreover, hederagenin and its 3-O-glycosides were found to be cytotoxic on various tumor cell lines, P-388, L-1210, U-937, HL-60, SNU-5 and HepG2, while 3,28-di-O-glycosides of hederagenin were not cytotoxic.
CONCLUSIONS:
Hence, hederagenin and its 3-O-glycosides could be suitable for cancer treatment chemopreventive drugs.
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