| In vitro: |
| Zhong Yao Cai. 2007 Jan;30(1):38-41. | | Study on the active components of Nardostachys chinensis.[Pubmed: 17539300] |
METHODS AND RESULTS:
To study on the active components of Nardostachys chinensis Batal, the compounds were isolated and purified by chromatographic methods, with their structures identified by spectral analysis and comparison with published data. 9 compounds were obtained and their structures were identified as acaciin, ursolie acid, octacosanol, Kanshone A, nardosinonediol, nardosinone, aristolen-9beta-ol, oleanolic acid and beta-sitosterol. Acaciin, ursolie acid and octacosanol were obtained from Nardostachys chinensis Batal. for the first time.
CONCLUSIONS:
Acaciin and ursolie are the active components of antihiotics and anti-inflammatory. | | Chem Pharm Bull (Tokyo). 1993 Jun;41(6):1183-4. | | Cytotoxic sesquiterpenes from Nardostachys chinensis.[Pubmed: 8370115] |
METHODS AND RESULTS:
Five cytostatic sesquiterpenes, desoxo-narchinol-A (1), nardosinone (2), debilon (3), nardosinonediol (4) and Kanshone A (5), were isolated from the roots and rhizomes of Nardostachys chinensis (Valerianaceae). The steric structure of 1 was determined by nuclear Overhauser effects (NOEs) and the exciton chirality method.
CONCLUSIONS:
All five showed cytotoxic activity against P-388 cells and the structure-activity relationship of 1 was also discussed. |
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