Karounidiol | CAS:118117-31-0 | Manufacturer ChemFaces

Karounidiol

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Karounidiol exhibits cytotoxicity especially against a human renal cancer, it markedly suppresses the promoting effect of TPA (1 microgram/mouse) on skin tumor formation in mice following initiation with 7,12-dimethylbenz[a]anthracene (50 micrograms/mouse).

In vitro:

Biol Pharm Bull. 1994 Mar;17(3):460-2.

Inhibitory effect of karounidiol on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion.[Pubmed: 8019519]

METHODS AND RESULTS:
Karounidiol [D:C-Friedo-oleana-7,9(11)-diene-3 alpha,29-diol] and 7-oxodihydroKarounidiol [7-oxo-D:C-friedo-olean-8-ene-3 alpha,29-diol], isolated from the seeds of Trichosanthes kirilowii, were examined for the effect on 12-O-tetradecanoylphorbol-13-acetate (TPA, 1 microgram/ear)-induced inflammation, following application of this tumor-promoting agent, to the ears of mice. Both compounds inhibited the inflammatory activity induced by TPA and the 50% inhibitory dose for TPA-induced inflammation was 0.3 and 0.4 mg/ear, respectively. Furthermore, at 2 mumol/mouse, Karounidiol markedly suppressed the promoting effect of TPA (1 microgram/mouse) on skin tumor formation in mice following initiation with 7,12-dimethylbenz[a]anthracene (50 micrograms/mouse).

Cancer Lett. 2001 Nov 8;173(1):9-14.

Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines.[Pubmed: 11578803]

METHODS AND RESULTS:
Forty-nine multiflorane-type triterpenoids consisting of 11 compounds isolated from the seeds of Trichosanthes kirilowii (Cucurbitaceae) and 38 of their derivatives have been evaluated for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in Raji cells as a primary screening test for anti-tumor promoters.
CONCLUSIONS:
All of the compounds tested showed an inhibitory effect against EBV-EA activation, and among which 43 were revealed to possess remarkable activity with potencies either comparable to or stronger than that of glycyrrhetic acid, a known natural anti-tumor promoter. Their structure-activity relationship is discussed. Evaluation of the cytotoxic activity of Karounidiol (27) against human cancer cell lines exhibited cytotoxicity especially against a human renal cancer.

Karounidiol Description

Source:	The seeds of Trichosanthes kirilowii Maxim.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Karounidiol
Price:
CAS No.:	118117-31-0
Catalog No.:	CFN90563
Molecular Formula:	C₃₀H₄₈O₂
Molecular Weight:	440.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The seeds of Trichosanthes kirilowii Maxim.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Cytotoxic Compound Library Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2691 mL	11.3456 mL	22.6912 mL	45.3823 mL	56.7279 mL
5 mM	0.4538 mL	2.2691 mL	4.5382 mL	9.0765 mL	11.3456 mL
10 mM	0.2269 mL	1.1346 mL	2.2691 mL	4.5382 mL	5.6728 mL
50 mM	0.0454 mL	0.2269 mL	0.4538 mL	0.9076 mL	1.1346 mL
100 mM	0.0227 mL	0.1135 mL	0.2269 mL	0.4538 mL	0.5673 mL

CFN98911	5-Glutinen-3-ol	545-24-4	426.7	C₃₀H₅₀O
CFN96385	Glutinol acetate	6426-44-4	468.8	C₃₂H₅₂O₂
CFN98802	Glutinone	508-09-8	424.7	C₃₀H₄₈O
CFN90563	Karounidiol	118117-31-0	440.7	C₃₀H₄₈O₂
CFN90562	Bryonolol	39765-50-9	442.7	C₃₀H₅₀O₂
CFN97818	Mupinensisone	152253-67-3	440.71	C₃₀H₄₈O₂
CFN90576	3,29-Dibenzoyl karounitriol	873001-54-8	666.94	C₄₄H₅₈O₅
CFN91175	3,29-O-Dibenzoyloxykarounidiol	389122-01-4	648.9	C₄₄H₅₆O₄
CFN89057	Friedelin 3,4-lactone	29621-75-8	442.72	C₃₀H₅₀O₂