Khellactone | CAS:24144-61-4 | Manufacturer ChemFaces

Khellactone

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Description:

Khellactone shows antitumor activity,it can suppress the growth of NCI-H460 tumor cells. (+)-4'-cis-Khellactone and (+)-3'-cis-khellactone have antiplasmodial activities, they show notable inhibitory activity against -sensitive strains of with IC(50) values from 1.5 and 2.4 microM.

Targets:

Antifection

In vitro:

Phytother Res. 2010 Mar;24(3):469-71.

Antiplasmodial and cytotoxic activity of khellactone derivatives from Angelica purpuraefolia Chung.[Pubmed: 19960419 ]

The methanolic extract of the rhizomes parts of Agelica purpuraefolia was investigated for its activity against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method.
METHODS AND RESULTS:
Two natural Khellactone, (+)-4'-Decanoyl-cis-Khellactone (1) and (+)-3'-Decanoyl-cis-Khellactone (2) were isolated from the rhizomes parts of A. purpuraefolia. Two compounds were evaluated for in vitro antiplasmodial activities as well as their cytotoxic potential on SK-OV-3 cancer cell line cells. Compounds 1, 2 showed notable growth inhibitory activity against chloroquine-sensitive strains of Plasmodium falciparum with IC(50) values from 1.5 and 2.4 microM. This compound showed no significant cytotoxicity (IC(50) > 100 microM) evaluated using SK-OV-3 cancer cell line cells.
CONCLUSIONS:
This is the first report on the antiplasmodial activity of the compounds from A. purpuraefolia.

In vivo:

Phytother Res. 2007 May;21(5):406-9.

Isolation of coumarins and ferulate from the roots of Angelica purpuraefolia and the antitumor activity of khellactone.[Pubmed: 17236175 ]

A new coumarin, hydroxylomatin (1), was isolated from the CHCl(3)-soluble fraction of the roots of Angelica purpuraefolia, along with one ferulate (2) and three other known coumarins (3-5) including Khellactone (3). The structure of hydroxylomatin (1) was determined to be 3'beta,5'-dihydroxy-3',4'-dihydroseselin (1) by spectroscopic means including 2D-NMR. The modified Mosher's method was used to determine the chiral center at C-1 of compound 2. Khellactone (3) is a major compound of the roots of A. purpuraefolia.
METHODS AND RESULTS:
This study also examined the antitumor activity of Khellactone (3) using a LLC mouse lung carcinoma in the BDF-1 mice and a NCI-H460 human lung carcinoma in a human tumor xenograft model in nude mice. This compound (3) inhibited LLC tumor growth with a T/C (mean value of treated group/mean value of control group) value of 12.9% at a dose of 5 mg/kg and 33.2% at a dose of 10 mg/kg, respectively, in a dose-dependent manner. In addition, it suppressed the growth of NCI-H460 tumor cells, accounting for 81.4% at a dose of 10 mg/kg in nude mice.

Khellactone Description

Source:	The roots of Angelica purpuraefolia.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Khellactone
Price:
CAS No.:	24144-61-4
Catalog No.:	CFN96394
Molecular Formula:	C₁₄H₁₄O₅
Molecular Weight:	262.3 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The roots of Angelica purpuraefolia.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Antimalaric Compound Library Coumarins Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.8124 mL	19.0621 mL	38.1243 mL	76.2486 mL	95.3107 mL
5 mM	0.7625 mL	3.8124 mL	7.6249 mL	15.2497 mL	19.0621 mL
10 mM	0.3812 mL	1.9062 mL	3.8124 mL	7.6249 mL	9.5311 mL
50 mM	0.0762 mL	0.3812 mL	0.7625 mL	1.525 mL	1.9062 mL
100 mM	0.0381 mL	0.1906 mL	0.3812 mL	0.7625 mL	0.9531 mL

CFN96695	Praeroside II	86940-46-7	424.40	C₂₀H₂₄O₁₀
CFN96375	Samidin	477-33-8	386.4	C₂₁H₂₂O₇
CFN89402	Hyuganin D	77331-76-1	374.38	C₂₀H₂₂O₇
CFN89386	(-)-Praeruptorin A	14017-71-1	386.39	C₂₁H₂₂O₇
CFN98143	Praeruptorin C	72463-77-5	428.48	C₂₄H₂₈O₇
CFN89387	(-)-Praeruptorin B	4970-26-7	426.45	C₂₄H₂₆O₇
CFN90570	Selinidin	19427-82-8	328.4	C₁₉H₂₀O₅
CFN92597	Qianhucoumarin E	156041-02-0	342.4	C₁₉H₁₈O₆
CFN92709	Qianhucoumarin A	150135-35-6	344.4	C₁₉H₂₀O₆
CFN96394	Khellactone	24144-61-4	262.3	C₁₄H₁₄O₅