Kongensin A | CAS:885315-96-8 | Manufacturer ChemFaces

Kongensin A

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Description:

Kongensin A is an effective heat shock protein 90 (HSP90) inhibitor that has potential anti-necroptosis and anti-inflammation applications.

Targets:

HSP (e.g. HSP90)

In vitro:

.Cell Chem Biol. 2016 Feb 18;23(2):257-66.

Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis.[Pubmed: 27028885 ]

RIP3-dependent necroptosis has recently garnered significant interest because of the unique signaling mechanisms and pathologic functions involved in this process. Accordingly, a number of chemical screens have identified several effective small-molecule inhibitors that specifically block necroptosis.
METHODS AND RESULTS:
Here, we report the discovery that Kongensin A (KA), a natural product isolated from Croton kongensis, is a potent inhibitor of necroptosis and an inducer of apoptosis. Using a new bioorthogonal ligation method (TQ ligation), we reveal that the direct cellular target of KA is heat shock protein 90 (HSP90). Further studies demonstrate that KA covalently binds to a previously uncharacterized cysteine 420 in the middle domain of HSP90 and dissociates HSP90 from its cochaperone CDC37, which leads to inhibition of RIP3-dependent necroptosis and promotion of apoptosis in multiple cancer cell lines.
CONCLUSIONS:
Collectively, our findings demonstrate that KA is an effective HSP90 inhibitor that has potential anti-necroptosis and anti-inflammation applications.

Kongensin A Description

Source:	The herbs of Croton cascarilloides
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Kongensin A
Price:
CAS No.:	885315-96-8
Catalog No.:	CFN97452
Molecular Formula:	C₂₂H₃₀O₅
Molecular Weight:	374.5 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Croton cascarilloides
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Inhibitors Compound Library Diterpenoids Compound Library HSP (e.g. HSP90) Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6702 mL	13.3511 mL	26.7023 mL	53.4045 mL	66.7557 mL
5 mM	0.534 mL	2.6702 mL	5.3405 mL	10.6809 mL	13.3511 mL
10 mM	0.267 mL	1.3351 mL	2.6702 mL	5.3405 mL	6.6756 mL
50 mM	0.0534 mL	0.267 mL	0.534 mL	1.0681 mL	1.3351 mL
100 mM	0.0267 mL	0.1335 mL	0.267 mL	0.534 mL	0.6676 mL

CFN90426	Mevastatin	73573-88-3	390.51	C₂₃H₃₄O₅
CFN99961	Lovastatin	75330-75-5	404.54	C₂₄H₃₆O₅
CFN90427	Simvastatin	79902-63-9	418.56	C₂₅H₃₈O₅
CFN90153	Sauchinone	177931-17-8	356.36	C₂₀H₂₀O₆
CFN92879	Fischeria A	221456-63-9	288.4	C₁₉H₂₈O₂
CFN97452	Kongensin A	885315-96-8	374.5	C₂₂H₃₀O₅
CFN99078	3,10-Dihydroxy-5,11-dielmenthadiene-4,9-dione	106623-23-8	332.4	C₂₀H₂₈O₄
CFN91050	Nephthenol	53915-41-6	290.49	C₂₀H₃₄O
CFN93208	Incensole	22419-74-5	306.5	C₂₀H₃₄O₂
CFN93207	Incensole acetate	34701-53-6	348.5	C₂₂H₃₆O₃