Structure Identification: |
Tetrahedron,1994,50( 7):2231–2240. | Lignans and neolignans from stems and fruits of Piper wightii[Reference: WebLink] |
METHODS AND RESULTS:
Two new neolignans, (7R,8R,3′R)-7-acetoxy-3′,4′-dimethoxy-3,4-methylenedioxy-6′-oxo-Δ-1′,4′,8′-8.3′-lignan (1) and (7R,8R,3′R)-7-hydroxy-3′,4′-dimethoxy-3,4-methylenedioxy-6′-oxo-Δ-1′,4′,8′-8.3′-lignan (2) were isolated from the petroleum ether extract of stems of Piper wightii Miq. The structure were elucidated on the basis of their spectroscopic analysis and chemical transformation. Additionally five known neolignans, isodihydrofutoquinol A (3) and isodihydrofutoquinol B (4), Lancifolin C (5) and D (6) and wallichinine (7) and two known α,α'-diaryl-β,β'-dimethyltetrahydrobenzofuran lignans, calopiptin (8) and machilin G (9), were isolated for the first time from Piper wightii.
CONCLUSIONS:
The new neolignan 2, isodihydrofutoquinol B (4), Lancifolin C (5) and wallichinine (7) were also isolated from the methanolic extract of fruits of the same species alongwith gelbelgin (10), also a known lignan of the tetrahydrobenzofuran type. |
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