Lathyrol | CAS:34420-19-4 | Manufacturer ChemFaces

Lathyrol

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $21.5 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Lathyrol diterpenes is a modulator of P-glycoprotein dependent multidrug resistance, and is used for cancer treatment.

Targets:

P-gp

In vitro:

J Med Chem. 2015 May 14;58(9):3720-38.

Lathyrol diterpenes as modulators of p-glycoprotein dependent multidrug resistance: structure-activity relationship studies on euphorbia factor l3 derivatives.[Pubmed: 25856545]

Five series of 37 new acylate and epoxide derivatives (3-39) of Euphorbia factor L3, a Lathyrol diterpene isolated from Euphorbia lathyris, were designed by modifying the hydroxyl moiety of C-3, C-5, or C-15. Chemoreversal effects of the acylates on multidrug resistance (MDR) were evaluated in breast cancer multidrug-resistant MCF-7/ADR cells that overexpress P-glycoprotein (P-gp).
METHODS AND RESULTS:
Eight derivatives exhibited greater chemoreversal ability than verapamil (VRP) against adriamycin (ADR) resistance. Compounds 19 and 25 exhibited 4.8 and 4.0 times, respectively, more effective reversal ability than VRP against ADR resistance. To determine the key characteristics of Euphorbia factor L3 derivatives that contribute to MDR reversal, we conducted a structure-activity relationship study of these compounds.
CONCLUSIONS:
The simulation studies indicated different possible mechanisms and revealed the important influence of hydrophobic interactions and hydrogen bonds in the flexible cavity of P-gp.

Lathyrol Description

Source:	The seeds of Euphorbia lathyris L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Lathyrol
Price:	$100 / 20mg
CAS No.:	34420-19-4
Catalog No.:	CFN98115
Molecular Formula:	C₂₀H₃₀O₄
Molecular Weight:	334.45 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	White powder
Source:	The seeds of Euphorbia lathyris L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-multidrug resistance Compound Library Diterpenoids Compound Library P-gp Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.99 mL	14.9499 mL	29.8998 mL	59.7997 mL	74.7496 mL
5 mM	0.598 mL	2.99 mL	5.98 mL	11.9599 mL	14.9499 mL
10 mM	0.299 mL	1.495 mL	2.99 mL	5.98 mL	7.475 mL
50 mM	0.0598 mL	0.299 mL	0.598 mL	1.196 mL	1.495 mL
100 mM	0.0299 mL	0.1495 mL	0.299 mL	0.598 mL	0.7475 mL

CFN92886	Euphorbia factor L8	218916-53-1	523.6	C₃₀H₃₇NO₇
CFN92887	Euphorbia factor L9	129393-28-8	643.7	C₃₇H₄₁NO₉
CFN88011	Euphorbia factor L11	N/A	600.7	C₃₆H₄₀O₈
CFN92884	Euphorbia factor L2	218916-51-9	642.7	C₃₈H₄₂O₉
CFN93011	17-Hydroxyisolathyrol	93551-00-9	350.45	C₂₀H₃₀O₅
CFN95338	Euphorbia factor L22	1613700-09-6	506.6	C₃₁H₃₈O₆
CFN92885	Euphorbia factor L7a	93550-94-8	548.7	C₃₃H₄₀O₇
CFN91052	Euphorbia factor L7b	93550-95-9	580.67	C₃₃H₄₀O₉
CFN95334	Euphorbia factor L24	1613700-13-2	538.6	C₃₁H₃₈O₈
CFN92878	Jolkinol A	62820-11-5	480.6	C₂₉H₃₆O₆