Science | Nature | Cell | View More
Natural Products
Lathyrol
Lathyrol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Lathyrol
Price: $100 / 20mg
CAS No.: 34420-19-4
Catalog No.: CFN98115
Molecular Formula: C20H30O4
Molecular Weight: 334.45 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: White powder
Source: The seeds of Euphorbia lathyris L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
More Impact Factor than five Cite...
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $21.5 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Our products had been exported to the following research institutions and universities, And still growing.
  • University of East Anglia (United Kingdom)
  • University of Stirling (United Kingdom)
  • Uniwersytet JagielloĊ„ski w Kra... (Poland)
  • Kitasato University (Japan)
  • University of Limpopo (South Africa)
  • University of Auckland (New Zealand)
  • Molecular Biology Institute of ... (Spain)
  • University of Padjajaran (Indonesia)
  • Georgia Institute of Technology (USA)
  • Kyushu University (Japan)
  • University of Eastern Finland (Finland)
  • More...
Package
Featured Products
More...
Pallidol

Catalog No: CFN92341
CAS No: 105037-88-5
Price: $318/10mg
8-Hydroxypinoresinol

Catalog No: CFN92432
CAS No: 81426-17-7
Price: $ / mg
Angustifoline

Catalog No: CFN92233
CAS No: 550-43-6
Price: $490/5mg
Peimine

Catalog No: CFN99996
CAS No: 23496-41-5
Price: $50/20mg
Notoginsenoside T5

Catalog No: CFN92824
CAS No: 769932-34-5
Price: $ / mg
Ginkgolide B

Catalog No: CFN99640
CAS No: 15291-77-7
Price: $40/20mg
Shuterin

Catalog No: CFN91904
CAS No: 105377-77-3
Price: $ / mg
Sinapic acid

Catalog No: CFN92631
CAS No: 530-59-6
Price: $30/20mg
Isosilybin B

Catalog No: CFN91071
CAS No: 142796-22-3
Price: $238/5mg
Sodium Danshensu

Catalog No: CFN99163
CAS No: 67920-52-9
Price: $40/20mg
Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Lathyrol diterpenes is a modulator of P-glycoprotein dependent multidrug resistance, and is used for cancer treatment.
Targets: P-gp
In vitro:
J Med Chem. 2015 May 14;58(9):3720-38.
Lathyrol diterpenes as modulators of p-glycoprotein dependent multidrug resistance: structure-activity relationship studies on euphorbia factor l3 derivatives.[Pubmed: 25856545]
Five series of 37 new acylate and epoxide derivatives (3-39) of Euphorbia factor L3, a Lathyrol diterpene isolated from Euphorbia lathyris, were designed by modifying the hydroxyl moiety of C-3, C-5, or C-15. Chemoreversal effects of the acylates on multidrug resistance (MDR) were evaluated in breast cancer multidrug-resistant MCF-7/ADR cells that overexpress P-glycoprotein (P-gp).
METHODS AND RESULTS:
Eight derivatives exhibited greater chemoreversal ability than verapamil (VRP) against adriamycin (ADR) resistance. Compounds 19 and 25 exhibited 4.8 and 4.0 times, respectively, more effective reversal ability than VRP against ADR resistance. To determine the key characteristics of Euphorbia factor L3 derivatives that contribute to MDR reversal, we conducted a structure-activity relationship study of these compounds.
CONCLUSIONS:
The simulation studies indicated different possible mechanisms and revealed the important influence of hydrophobic interactions and hydrogen bonds in the flexible cavity of P-gp.
Lathyrol Description
Source: The seeds of Euphorbia lathyris L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
New Products More...
3'-Hydroxy-5,7,4',5'-Tetramethoxyf...

Catalog No: CFN95397
CAS No: 29976-51-0
Price: $318/5mg
Oxytroflavoside D

Catalog No: CFN95491
CAS No: 1391144-83-4
Price: $318/10mg
1-O-Feruloylglucose

Catalog No: CFN95596
CAS No: 64625-37-2
Price: $413/5mg
20-O-Glucoginsenoside Rf

Catalog No: CFN95036
CAS No: 68406-27-9
Price: $318/5mg
Oxyphyllol B

Catalog No: CFN95575
CAS No: 226546-99-2
Price: $/mg
Shancigusin I

Catalog No: CFN95061
CAS No: 1435488-35-9
Price: $/mg
Mahuannin J

Catalog No: CFN95533
CAS No: N/A
Price: $318/5mg
Resinacein D

Catalog No: CFN95591
CAS No: 2231061-47-3
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.99 mL 14.9499 mL 29.8998 mL 59.7997 mL 74.7496 mL
5 mM 0.598 mL 2.99 mL 5.98 mL 11.9599 mL 14.9499 mL
10 mM 0.299 mL 1.495 mL 2.99 mL 5.98 mL 7.475 mL
50 mM 0.0598 mL 0.299 mL 0.598 mL 1.196 mL 1.495 mL
100 mM 0.0299 mL 0.1495 mL 0.299 mL 0.598 mL 0.7475 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN95338Euphorbia factor L221613700-09-6506.6C31H38O6
CFN92885Euphorbia factor L7a93550-94-8548.7C33H40O7
CFN91052Euphorbia factor L7b93550-95-9580.67C33H40O9
CFN95334Euphorbia factor L241613700-13-2538.6C31H38O8
CFN92878Jolkinol A62820-11-5480.6C29H36O6
CFN98559Epoxylathyrol28649-60-7350.45C20H30O5
CFN95339Euphorbia factor L25303174-98-3538.6C31H38O8
CFN92883Euphorbia factor L176376-43-7552.7C32H40O8
CFN95340Deoxy euphorbia factor L1247099-01-0536.7C32H40O7
CFN95342New compound 9N/A538.6C31H38O8
Featured Products
Pallidol

Catalog No: CFN92341
CAS No: 105037-88-5
Price: $318/10mg
8-Hydroxypinoresinol

Catalog No: CFN92432
CAS No: 81426-17-7
Price: $ / mg
Angustifoline

Catalog No: CFN92233
CAS No: 550-43-6
Price: $490/5mg
Peimine

Catalog No: CFN99996
CAS No: 23496-41-5
Price: $50/20mg
Notoginsenoside T5

Catalog No: CFN92824
CAS No: 769932-34-5
Price: $ / mg
Ginkgolide B

Catalog No: CFN99640
CAS No: 15291-77-7
Price: $40/20mg
Shuterin

Catalog No: CFN91904
CAS No: 105377-77-3
Price: $ / mg
Sinapic acid

Catalog No: CFN92631
CAS No: 530-59-6
Price: $30/20mg
Isosilybin B

Catalog No: CFN91071
CAS No: 142796-22-3
Price: $238/5mg
Sodium Danshensu

Catalog No: CFN99163
CAS No: 67920-52-9
Price: $40/20mg
Tags: buy Lathyrol | Lathyrol supplier | purchase Lathyrol | Lathyrol cost | Lathyrol manufacturer | order Lathyrol | Lathyrol distributor
1 Building, No. 176, CheCheng East Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Copyright© 2011-2023 | ChemFaces all rights reserved | Tel: +86-27-84237683
E-mail:manager@chemfaces.com
payment