Cyanidin-3-O-sambubioside chloride | CAS:33012-73-6

Cyanidin-3-O-sambubioside chloride

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Description:

Cyanidin-3-O-sambubioside chloride is inhibitors of BPDE-induced NFκB activity. It inhibits the enzyme activity by competing with the substrate for the active site. Cyanidin-3-O-sambubioside chloride has antioxidant activity and free-radical-scavenging property.

Targets:

NF-kB | ROS

In vitro:

J Biomol Struct Dyn . 2018 Dec;36(16):4255-4269.

The inhibitory performance of flavonoid cyanidin-3-sambubiocide against H274Y mutation in H1N1 influenza virus[Pubmed: 29199545]

Abstract Oseltamivir (Tamiflu) is the most accepted antiviral drug that targets the neuraminidase (NA) protein to inhibit the viral release from the host cell. Few H1N1 influenza strains with the H274Y mutation creates drug resistance to oseltamivir. In this study, we report that flavonoid cyanidin-3-sambubiocide (C3S) compound acts as a potential inhibitor against H274Y mutation. The drug resistance mechanism and inhibitory activity of C3S and oseltamivir against wild-type (WT) and H274Y mutant-type (MT) have been studied and compared based on the results of molecular docking, molecular dynamics, and quantum chemical methods. Oseltamivir has been found less binding affinity with MT. C3S has more binding affinity with WT and MT proteins. From the dynamical study, the 150th loop of the MT protein has found more deformation than WT. A single H274Y mutation induces the conformational changes in the 150th loop which leads to produce more resistance to oseltamivir. The 150th cavity is more attractive target for C3S to stop the conformational changes in the MT, than 430th cavity of NA protein. The C3S is stabilized with MT by more number of hydrogen bonds than oseltamivir. The electrostatic interaction energy shows a stronger C3S binding with MT and this compound may be more effective against oseltamivir-resistant virus strains. Keywords: H274Y mutation; Influenza virus; drug resistance; molecular docking; molecular dynamic simulation.

Planta Med . 2013 Nov;79(17):1636-40.

Cyanidin-3-O-sambubioside from Acanthopanax sessiliflorus fruit inhibits metastasis by downregulating MMP-9 in breast cancer cells MDA-MB-231[Pubmed: 24214832]

Abstract Anthocyanins play an important role in physiological functions related to human health. This study aimed to investigate the inhibitory effect of cyanidin-3-O-sambubioside isolated from Acanthopanax sessiliflorus fruit on cancer cell metastasis. The inhibitory effect of cyanidin-3-O-sambubioside on angiogenesis was assessed by chorioallantoic membrane and tube formation assays. Cyanidin-3-O-sambubioside interrupted the formation of neovasculature and tube-like structures in a dose-dependent manner. It inhibited the wound healing migration and invasion of MDA-MB-231 cells through reconstituted extracellular matrix (Matrigel). Gelatin zymography revealed that cyanidin-3-O-sambubioside significantly decreased the secretion of matrix metalloproteinase-9 and inhibited matrix metalloproteinase-9 expression. In additional, cyanidin-3-O-sambubioside exerted an inhibitory effect on Akt phosphorylation. These results suggest that cyanidin-3-O-sambubioside inhibits metastasis processes, such as angiogenesis and invasion, in breast cancer cells through regulation of matrix metalloproteinase-9 activity. Georg Thieme Verlag KG Stuttgart · New York.

Cyanidin-3-O-sambubioside chloride Description

Source:	The fruits of Vaccinium myrtillus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Cyanidin-3-O-sambubioside chloride
Price:	$643 / 10mg
CAS No.:	33012-73-6
Catalog No.:	CFN92173
Molecular Formula:	C₂₆H₂₉ClO₁₅
Molecular Weight:	617.0 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The fruits of Vaccinium myrtillus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Anti-metastatic Compound Library Flavonoids Compound Library ROS Inhibitor Library NF-kB Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6207 mL	8.1037 mL	16.2075 mL	32.4149 mL	40.5186 mL
5 mM	0.3241 mL	1.6207 mL	3.2415 mL	6.483 mL	8.1037 mL
10 mM	0.1621 mL	0.8104 mL	1.6207 mL	3.2415 mL	4.0519 mL
50 mM	0.0324 mL	0.1621 mL	0.3241 mL	0.6483 mL	0.8104 mL
100 mM	0.0162 mL	0.081 mL	0.1621 mL	0.3241 mL	0.4052 mL

CFN91858	Luteolinidin chloride	1154-78-5	306.7	C₁₅H₁₁ClO₅
CFN91863	Apigeninidin chloride	1151-98-0	290.7	C₁₅H₁₁ClO₄
CFN91861	Fisetinidin chloride	2948-76-7	306.7	C₁₅H₁₁ClO₅
CFN91856	Robinetinidin chloride	3020-09-5	322.7	C₁₅H₁₁ClO₆
CFN92038	Delphinidin-3-O-glucoside chloride	6906-38-3	500.8	C₂₁H₂₁ClO₁₂
CFN92037	Delphinidin-3-O-galactoside chloride	28500-00-7	500.8	C₂₁H₂₁ClO₁₂
CFN92171	Delphinidin-3-sambubioside chloride	53158-73-9	633.0	C₂₆H₂₉O₁₆Cl
CFN92136	Delphinidin-3-O-rutinoside chloride	15674-58-5	645.0	C₂₇H₃₁O₁₆Cl
CFN92137	Delphinidin-3,5-O-diglucoside chloride	17670-06-3	663.0	C₂₇H₃₁O₁₇Cl
CFN91870	Delphinidin-3-O-sambubioside-5-O-glucoside chloride	36415-91-5	795.1	C₃₂H₃₉ClO₂₁