Lemannine | CAS:58480-54-9 | Manufacturer ChemFaces

Lemannine

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Standard reference

In vitro:

AAPS PharmSciTech. 2010 Sep;11(3):1350-8.

Preparation and in vitro evaluation of ethosomal total alkaloids of Sophora alopecuroides loaded by a transmembrane pH-gradient method.[Pubmed: 20740333]

A novel transmembrane pH gradient active loading method to prepare alkaloids binary ethosomes was developed in this work. Using this novel method, binary ethosomes containing total alkaloids extracted from Sophora alopecuroides (TASA) were prepared successfully at the temperature below the phase transition temperature (Tc) of the phosphatidyl choline (PC). Several factors affecting this method were investigated.
METHODS AND RESULTS:
The qualities of the TASA binary ethosomes were characterized by the shape, particle size, and encapsulation efficiency (EE). The percutaneous absorption study of TASA binary ethosomes was performed using confocal laser scanning microscopy and Franz diffusion cells. The results showed that more than 90% sophoridine, 47% matrine, 35% sophocarpine, and 32% Lemannine in TASA were entrapped within 1 h at 40°C, with an efficiency improvement of 8.87, 8.10, 7.63, and 7.78-fold than those observed in passive loading method. Transdermal experiments showed that the penetration depth and fluorescence intensity of Rhodamine B from binary ethosome prepared by pH gradient active loading method were much greater than that from binary ethosome prepared by passive loading method or hydroalcoholic solution.
CONCLUSIONS:
These results suggested transmembrane pH gradient active loading method may be an effective method to prepare alkaloids ethosomal systems at the temperatures below the Tc of PC.

Lemannine Description

Source:	The herbs of Ammothamnus lehmannii
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Lemannine
Price:
CAS No.:	58480-54-9
Catalog No.:	CFN92839
Molecular Formula:	C₁₅H₂₂N₂O
Molecular Weight:	246.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Cryst.
Source:	The herbs of Ammothamnus lehmannii
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.0584 mL	20.2922 mL	40.5844 mL	81.1688 mL	101.461 mL
5 mM	0.8117 mL	4.0584 mL	8.1169 mL	16.2338 mL	20.2922 mL
10 mM	0.4058 mL	2.0292 mL	4.0584 mL	8.1169 mL	10.1461 mL
50 mM	0.0812 mL	0.4058 mL	0.8117 mL	1.6234 mL	2.0292 mL
100 mM	0.0406 mL	0.2029 mL	0.4058 mL	0.8117 mL	1.0146 mL

CFN90222	Allomatrine	641-39-4	248.36	C₁₅H₂₄N₂O
CFN97172	Sophoridine	6882-68-4	248.4	C₁₅H₂₄N₂O
CFN90290	Oxysophoridine	54809-74-4	264.36	C₁₅H₂₄N₂O₂
CFN98321	Oxysophocarpine	26904-64-3	262.4	C₁₅H₂₂N₂O₂
CFN98835	Matrine	519-02-8	248.4	C₁₅H₂₄N₂O
CFN92839	Lemannine	58480-54-9	246.4	C₁₅H₂₂N₂O
CFN98875	Neosophoramine	52932-74-8	244.3	C₁₅H₂₀N₂O
CFN99182	Sophocarpine	145572-44-7	246.35	C₁₅H₂₂N₂O
CFN99805	Oxymatrine	16837-52-8	264.4	C₁₅H₂₄N₂O₂
CFN92840	(+)-Sophoranol	3411-37-8	264.4	C₁₅H₂₄N₂O₂