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Lobelanidine
Lobelanidine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Lobelanidine
Price:
CAS No.: 579-21-5
Catalog No.: CFN00444
Molecular Formula: C22H25NO2
Molecular Weight: 335.44 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Lobelia chinensis Lour.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Lobelanidine is a chemical constituent from from Lobelia chinensis Lour, Lobelia chinensis Lour possesses a number of pharmacological activities (e.g., diuretic, choleretic, breathing excitement, anti-venom, anti-bacterial, and anticancer).
In vitro:
Chin J Nat Med. 2014 Feb;12(2):103-7.
Lobelia chinensis: chemical constituents and anticancer activity perspective.[Pubmed: 24636059]

METHODS AND RESULTS:
Research has demonstrated that many chemical constituents dominated by piperidine alkaloids and flavonoids, such as Lobelanidine, lobeline, and lobelanine, have been obtained from Lobelia chinensis Lour. Experimental studies and clinical applications have also indicated that L. chinensis possesses a number of pharmacological activities (e.g., diuretic, choleretic, breathing excitement, anti-venom, anti-bacterial, and anticancer).
CONCLUSIONS:
This paper focuses on the properties, chemical constituents, and anticancer activity of L. chinensis to clarify the connection among them, and identify the active anticancer compounds. This work serves as the foundation for further research and development of L. chinensis.
Lobelanidine Description
Source: The herbs of Lobelia chinensis Lour.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9812 mL 14.9058 mL 29.8116 mL 59.6232 mL 74.529 mL
5 mM 0.5962 mL 2.9812 mL 5.9623 mL 11.9246 mL 14.9058 mL
10 mM 0.2981 mL 1.4906 mL 2.9812 mL 5.9623 mL 7.4529 mL
50 mM 0.0596 mL 0.2981 mL 0.5962 mL 1.1925 mL 1.4906 mL
100 mM 0.0298 mL 0.1491 mL 0.2981 mL 0.5962 mL 0.7453 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Bioorg Med Chem. 2009 Mar 1;17(5):1837-9.
Synthesis of (-)-lobeline via enzymatic desymmetrization of lobelanidine.[Pubmed: 19217305]

METHODS AND RESULTS:
The bioactive alkaloid (-)-lobeline was synthesized via the stereoselective acylation (desymmetrization) of meso-Lobelanidine by vinyl acetate in the presence of Candida antarctica lipase B.
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CAS No: 51014-29-0
Price: $128/20mg
N-trans-caffeoyltyramine

Catalog No: CFN95265
CAS No: 103188-48-3
Price: $318/5mg
Ginsenoside Re

Catalog No: CFN99974
CAS No: 52286-59-6
Price: $40/20mg
Napellonine

Catalog No: CFN90393
CAS No: 509-24-0
Price: $218/20mg
Corylin

Catalog No: CFN98902
CAS No: 53947-92-5
Price: $90/20mg
Oroxin A

Catalog No: CFN99712
CAS No: 57396-78-8
Price: $128/20mg
Ginsenoside Rd2 (Quinquenoside L10)

Catalog No: CFN95231
CAS No: 83480-64-2
Price: $318/10mg
Chrysin

Catalog No: CFN98741
CAS No: 480-40-0
Price: $40/20mg
Hyperoside

Catalog No: CFN98754
CAS No: 482-36-0
Price: $50/20mg
9-Hydroxycalabaxanthone

Catalog No: CFN98467
CAS No: 35349-68-9
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