Longiferone B | CAS:1639810-67-5 | Manufacturer ChemFaces

Longiferone B

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Description:

Longiferone B shows anti-inflammatory activity against NO release with IC50 values of 21.0 uM, it also suppresses the iNOS and COX-2 mRNA expression.

Targets:

NO | NOS | COX

In vitro:

J Ethnopharmacol. 2014 Jun 11;154(2):453-61

Anti-inflammatory activity of compounds from Boesenbergia longiflora rhizomes.[Pubmed: 24786574 ]

METHODS AND RESULTS:
The isolation of the CHCl3 fraction from Boesenbergia longiflora rhizomes led to the isolation of three new daucane sesquiterpenes, which were identified as 8-hydroxy-dauca-9, 11-diene-7-one (longiferone A; 1), dauca-8, 11-diene-7-one (Longiferone B; 2) and dauca-8, 11-diene-7, 10-dione (longiferone C; 3); together with four known flavonoids, six known diarylheptanoids as well as one sterol. The Longiferone B (2) and longiferone C (3) showed anti-inflammatory activity against NO release with IC50 values of 21.0 and 31.3μM, respectively. Longiferone B (2) also suppressed the iNOS and COX-2 mRNA expression. Moreover, the flavonoids and diarylheptanoids inhibited NO and TNF-α production in a dose dependent manner.
CONCLUSIONS:
This study demonstrated that sesquiterpenes, diarylheptanoids and some methoxyflavonoids found in Boesenbergia longiflora are responsible for anti-inflammatory activity.

Longiferone B Description

Source:	The rhizomes of Boesenbergia longiflora (Wall.) Kuntze.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Longiferone B
Price:
CAS No.:	1639810-67-5
Catalog No.:	CFN89084
Molecular Formula:	C₁₅H₂₂O
Molecular Weight:	218.34 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Oil
Source:	The rhizomes of Boesenbergia longiflora (Wall.) Kuntze.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Sesquiterpenoids Compound Library NOS Inhibitor Library NO Inhibitor Library COX Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.58 mL	22.9001 mL	45.8001 mL	91.6003 mL	114.5003 mL
5 mM	0.916 mL	4.58 mL	9.16 mL	18.3201 mL	22.9001 mL
10 mM	0.458 mL	2.29 mL	4.58 mL	9.16 mL	11.45 mL
50 mM	0.0916 mL	0.458 mL	0.916 mL	1.832 mL	2.29 mL
100 mM	0.0458 mL	0.229 mL	0.458 mL	0.916 mL	1.145 mL

CFN97146	10(14)-Cadinene-4,5-diol	672336-50-4	238.4	C₁₅H₂₆O₂
CFN98278	Isocalamendiol	25330-21-6	238.4	C₁₅H₂₆O₂
CFN96767	10-O-Acetylisocalamendiol	1432064-69-1	280.40	C₁₇H₂₈O₃
CFN98081	4-Cadinen-7-ol	217650-27-6	222.4	C₁₅H₂₆O
CFN95246	(-)-Cadin-4,10(15)-dien-11-oic acid	1124353-23-6	234.3	C₁₅H₂₂O₂
CFN97485	3-Acetoxy-4-cadinen-8-one	923950-05-4	278.4	C₁₇H₂₆O₃
CFN99071	9-Oxoageraphorone	105181-06-4	234.3	C₁₅H₂₂O₂
CFN97514	1,3,5-Cadinatriene-3,8-diol	941227-27-6	234.3	C₁₅H₂₂O₂
CFN97550	8-Hydroxy-4-cadinen-3-one	97372-53-7	236.4	C₁₅H₂₄O₂
CFN98653	Lacinilene C	41653-72-9	246.3	C₁₅H₁₈O₃