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Mesuol
Mesuol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Mesuol
Price:
CAS No.: 16981-20-7
Catalog No.: CFN96288
Molecular Formula: C24H24O5
Molecular Weight: 392.5 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Yellow powder
Source: The stem barks of Mesua borneensis L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical; it also has immunomodulatory activity, can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and phagocytosis in carbon clearance assay. Mesuol can suppress HIV-1 replication in Jurkat T cells, it inhibits TNFα-induced HIV-1-LTR transcriptional activity by targeting the nuclear factor-κB (NF-κB) pathway.
Targets: HIV | NF-kB | LTR | TNF-α
In vitro:
Antiviral Res. 2005 Jun;66(2-3):137-45
Mesuol, a natural occurring 4-phenylcoumarin, inhibits HIV-1 replication by targeting the NF-kappaB pathway.[Pubmed: 15911030 ]
Coumarins and structurally related compounds have been recently shown to inhibit replication of human immunodeficiency virus (HIV) and thus, exhibit a therapeutic potential.
METHODS AND RESULTS:
In this study we report that Mesuol and isoMesuol, two 4-phenyl coumarins, isolated from the tree Marila pluricostata, suppress HIV-1 replication in Jurkat T cells. These coumarins do not affect the reverse transcription and integration steps of the viral cycle and their antiviral effect is additive with that of azidothymidine (AZT). In addition, Mesuol inhibits TNFalpha-induced HIV-1-LTR transcriptional activity by targeting the nuclear factor-kappaB (NF-kappaB) pathway. While Mesuol does not prevent either the binding of NF-kappaB to DNA or the phosphorylation and degradation of NF-kappaB inhibitory protein, IkappaBalpha, it inhibits the phosphorylation and the transcriptional activity of the NF-kappaB p65 subunit in TNFalpha-stimulated cells.
CONCLUSIONS:
These results highlight the potential of the NF-kappaB transcription factor as a target for anti-HIV-1 compounds such as 4-phenyl coumarins, which could serve as lead compounds for the development of additional therapeutic approaches against AIDS.
Journal of Biologically Active Products from Nature, 2016,6(2):95-100.
Antimalarial and Antioxidant Activities of Isoprenylated Coumarins from the Stem Bark of L.[Reference: WebLink]
The aim of this study was to assess the antimalarial and antioxidant effects of the n-hexane and ethyl acetate extracts together with three isolated isoprenylated coumarins, mammea A/BA(1),mammea A/ AA cyclo D (2) and Mesuol (3) from the stem bark of M. borneensis L.
METHODS AND RESULTS:
The n-hexane and ethyl acetate extracts, as well as compounds 1-3 were evaluated for their antimalarial activity against Plasmodium falciparum strain 3D7 (chloroquine-sensitive) and their antioxidant activity against DPPH radical scavenging.
CONCLUSIONS:
Compound 2 exhibited slightly more active than chloroquine. Compounds 1 and 3 showed very high activity against DPPH radical.
In vivo:
Int Immunopharmacol. 2012 Aug;13(4):386-91.
In-vivo antioxidant and immunomodulatory activity of mesuol isolated from Mesua ferrea L. seed oil.[Pubmed: 22634479 ]
Mesua ferrea L. (Nagkesar) is traditionally being used for antiseptic, anti-inflammatory, antiasthmatic and antiallergic activities. It is an ingredient of ayurvedic formulations like Brahma Rasayana and Chyavanprash which are being used to improve immunity. The present study was performed to evaluate immunomodulatory activity of Mesuol isolated from M. ferrea seed oil in experimental animals.
METHODS AND RESULTS:
In humoral immune response model, Mesuol evoked a significant dose dependent increase in antibody titer values in cyclophosphamide (50 mg/kg, i.p., 9th and 16th day) induced immunosuppression which was sensitized with sheep red blood cells (SRBC) on the 7th and 14th day of experiment. In cellular immune response model, an increase in paw volume was recorded on the 23rd day in cyclophosphamide-induced immunosuppressed rats treated with SRBC (0.03 ml 2% v/v, s.c.) on the 21st day. Mesuol restored the hematological profile in cyclophosphamide induced myelosuppression model. Mesuol potentiated percentage neutrophil adhesion in neutrophil adhesion test in rats and phagocytosis in carbon clearance assay.
CONCLUSIONS:
The study indicated immunomodulatory activity of Mesuol.
Mesuol Description
Source: The stem barks of Mesua borneensis L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

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Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5478 mL 12.7389 mL 25.4777 mL 50.9554 mL 63.6943 mL
5 mM 0.5096 mL 2.5478 mL 5.0955 mL 10.1911 mL 12.7389 mL
10 mM 0.2548 mL 1.2739 mL 2.5478 mL 5.0955 mL 6.3694 mL
50 mM 0.051 mL 0.2548 mL 0.5096 mL 1.0191 mL 1.2739 mL
100 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.5096 mL 0.6369 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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