Methyl isocostate | CAS:132342-55-3 | Manufacturer ChemFaces

Methyl isocostate

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Methyl isocostate Description

Source:	The roots of Aucklandia lappa Decne
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

The Natural Products Journal, 2019, 9(4):262-267.

Synthesis of Spiro-Isoxazolidine Derivatives of Methyl α-Isocostate.[Reference: WebLink]

In recent decades, natural products are an important source of chemotherapeutics as more than half of the effective cancer drugs can be traced to natural origins. Moreover, the modification of natural products is one of the most common and fruitful approaches to obtain novel therapeutic agents in medicinal chemistry.
METHODS AND RESULTS:
Continuing with a research project based on the support of Moroccan plant resources. we report herein the use of α-isocostic acid extracted in enantiomerically pure form from Dittrichia viscosa as a convenient starting material for the synthesis of new eudesmane derivatives. Novel spiro derivatives with a natural scaffold were prepared. Spiro-isoxazolidine derivatives were generated on the exocyclic double bond adjacent to the ester α,β-unsaturated function by 1,3-dipolar cycloaddition of methyl α-isocostate(Methyl isocostate) 1 derived from sesquiterpenic isocostic acid, with nitrones 2.
CONCLUSIONS:
This procedure allowed us to generate enantiomerically pure spiro compounds in one diastereoisomer form with a limited number of steps. These compounds were fully characterized by spectroscopic methods.

Product Name	Methyl isocostate
Price:
CAS No.:	132342-55-3
Catalog No.:	CFN99408
Molecular Formula:	C₁₆H₂₄O₂
Molecular Weight:	248.4 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Oil
Source:	The roots of Aucklandia lappa Decne
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Sesquiterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.0258 mL	20.1288 mL	40.2576 mL	80.5153 mL	100.6441 mL
5 mM	0.8052 mL	4.0258 mL	8.0515 mL	16.1031 mL	20.1288 mL
10 mM	0.4026 mL	2.0129 mL	4.0258 mL	8.0515 mL	10.0644 mL
50 mM	0.0805 mL	0.4026 mL	0.8052 mL	1.6103 mL	2.0129 mL
100 mM	0.0403 mL	0.2013 mL	0.4026 mL	0.8052 mL	1.0064 mL

CFN99404	5alpha-Hydroxycostic acid	132185-83-2	250.3	C₁₅H₂₂O₃
CFN99405	5beta-Hydroxycostic acid	132185-84-3	250.3	C₁₅H₂₂O₃
CFN99861	Pterodontic acid	185845-89-0	234.3	C₁₅H₂₂O₂
CFN99860	2,3-Dihydroxypterodontic acid	185821-32-3	266.3	C₁₅H₂₂O₄
CFN95181	New compound 2	N/A	266.3	C₁₅H₂₂O₄
CFN99408	Methyl isocostate	132342-55-3	248.4	C₁₆H₂₄O₂
CFN95322	alpha-Costic acid	28399-17-9	234.3	C₁₅H₂₂O₂
CFN95183	Pterodonoic acid	62458-42-8	248.3	C₁₅H₂₀O₃
CFN98687	Ilicic acid	4586-68-9	252.4	C₁₅H₂₄O₃
CFN98498	beta-Costic acid	3650-43-9	234.3	C₁₅H₂₂O₂