Miltipolone | CAS:131086-61-8 | Manufacturer ChemFaces

Miltipolone

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Miltipolone is a good and broad-spectrum inhibitor against the growth of cancer cells. It also possibly acts as a Fe(2+) chelator to conduct its inhibitory activity.

In vitro:

Eur J Med Chem. 2011 Apr;46(4):1117-21.

Identification, structural properties and chelating capacity of miltipolone as a broad-spectrum inhibitor to cancer cells.[Pubmed: 21296467 ]

Miltipolone (1) was discovered as a good and broad-spectrum inhibitor against the growth of cancer cells from "Danshen" based on the activity-driven screening of TCMs.
METHODS AND RESULTS:
The structural features make 1 easily tautomerize between different forms and 1 is linked and stabilized by intermolecular O-H⋯O hydrogen bonds in the crystal structure. The interaction of 1 in ddH(2)O solution with Co(2+), Mn(2+), Zn(2+), Fe(2+) or Fe(3+) changed UV absorption values; the chelation of 1 with Fe(2+) or Fe(3+) also altered the characteristic UV absorption peaks. However, only did Fe(2+) reverse 1's inhibition against the growth of cancer cells;
METHODS AND RESULTS:
therefore, we concluded that 1 possibly acts as a Fe(2+) chelator to conduct its inhibitory activity.

Miltipolone Description

Source:	The roots of Salvia miltiorrhiza
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Miltipolone
Price:
CAS No.:	131086-61-8
Catalog No.:	CFN92250
Molecular Formula:	C₁₉H₂₄O₃
Molecular Weight:	300.4 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The roots of Salvia miltiorrhiza
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Metal-chelators Compound Library Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3289 mL	16.6445 mL	33.2889 mL	66.5779 mL	83.2224 mL
5 mM	0.6658 mL	3.3289 mL	6.6578 mL	13.3156 mL	16.6445 mL
10 mM	0.3329 mL	1.6644 mL	3.3289 mL	6.6578 mL	8.3222 mL
50 mM	0.0666 mL	0.3329 mL	0.6658 mL	1.3316 mL	1.6644 mL
100 mM	0.0333 mL	0.1664 mL	0.3329 mL	0.6658 mL	0.8322 mL

CFN98258	Celaphanol A	244204-40-8	288.3	C₁₇H₂₀O₄
CFN98301	7,15-Dihydroxypodocarp-8(14)-en-13-one	262355-96-4	278.4	C₁₇H₂₆O₃
CFN96108	13-Oxopodocarp-8(14)-en-18-oic acid	63976-69-2	276.4	C₁₇H₂₄O₃
CFN97054	13-Hydroxy-8,11,13-podocarpatrien-18-oic acid	61597-83-9	274.4	C₁₇H₂₂O₃
CFN96033	16-Nor-15-oxodehydroabietic acid	200813-31-6	300.4	C₁₉H₂₄O₃
CFN96993	16-Nor-7,15-dioxodehydroabietic acid	120591-53-9	314.38	C₁₉H₂₂O₄
CFN97250	13-Methyl-8,11,13-podocarpatriene-3,12-diol	769140-74-1	274.4	C₁₈H₂₆O₂
CFN99306	Przewalskin	119400-87-2	272.4	C₁₈H₂₄O₂
CFN92250	Miltipolone	131086-61-8	300.4	C₁₉H₂₄O₃
CFN99415	Heudelotinone	133453-58-4	268.4	C₁₈H₂₀O₂