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Moracin D
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Product Name Moracin D
Price:
CAS No.: 69120-07-6
Catalog No.: CFN97179
Molecular Formula: C19H16O4
Molecular Weight: 308.3 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The root barks of Morus alba L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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Similar structural: Comparison (Web)  (SDF)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization of Moracin may open a new avenue in the treatment of tumerigenesis.
Targets: COX | c-Myc | TNF-α | Antifection
In vitro:
Molecules. 2011 Jul 19;16(7):6010-22.
Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells.[Pubmed: 21772233]

METHODS AND RESULTS:
A new arylbenzofuran, 3',5'-dihydroxy-6-methoxy-7-prenyl-2-arylbenzofuran (1), and 25 known compounds, including moracin R (2), moracin C (3), moracin O (4), moracin P (5), artoindonesianin O (6), Moracin D (7), alabafuran A (8), mulberrofuran L (9), mulberrofuran Y (10), kuwanon A (11), kuwanon C (12), kuwanon T (13), morusin (14), kuwanon E (15), sanggenon F (16), betulinic acid (17), uvaol (18), ursolic acid (19), β-sitosterol (20), oxyresveratrol 2-O-β-D-glucopyranoside (21), mulberroside A (22), mulberroside B (23), 5,7-dihydroxycoumarin 7-O-β-D-glucopyranoside (24), 5,7-dihydroxycoumarin 7-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (25) and adenosine (26), were isolated from Morus alba var. multicaulis Perro. (Moraceae). Their structures were determined by spectroscopic methods.
CONCLUSIONS:
The prenyl-flavonoids 11-14, 16, triterpenoids 17,18 and 20 showed significant inhibitory activity towards the differentiation of 3T3-L1 adipocytes. The arylbenzofurans 1-10 and prenyl-flavonoids 11-16 also showed significant nitric oxide (NO) production inhibitory effects in RAW264.7 cells.
In vivo:
Annals of Plant Sciences, 2013,2(10):412-9.
Effect of Moracin on DMBA-TPA induced skin cancer in the mice, Mus musculus (L).[Reference: WebLink]
The phytochemicals serves to orchestrate the healthy metabolism in the animal cells. The efforts in the study were conducted to assess the protective influence of Moracin, the major constituent of leaves of mulberry, Morus alba (L.) on tumor promotion in 7, 12 – dimethylbenz (alpha) anthracene (DMBA) – initiated and 12-O-tetradecanoylphorbol 13-acetate (TPA) – promoted mouse skin tumerigenesis model.
METHODS AND RESULTS:
The acetone solution of Moracin was topically applied to DMBA – initiated female mouse (Mus musculus) skin at the dosage of 2.5 and 5 mg twice per week for sixteen weeks, thirty minutes prior to each promotion treatment with TPA in the first experimental schedule. The significant reduction in tumor incidence and tumor multiplicity effects were evident in the treated group. The expression of tumor necrosis factor (TNF) – alpha protein and the level of 4-hydroxynoneal (4HNE) in the normal epidermis were significantly reduced in both moracin treated groups. Moracin at the dosage of 5 mg was topically applied to the dorsal surface of mouse skin 30 minutes before application of a TPA in the second effort in the study. And the same dosages of TPA and Moracin were applied twice at the interval of 24 hours. Moracin treatment was found inhibiting the double TPA treatment – induced morphological changes reflecting inflammatory response, including leucocyte infiltration, hyperplasia and cell proliferation. Moracin treatment furthermore significantly suppressed the elevation in 4-HNE level and elevated expression of c-fos, c-myc and cycloxygenase-2 (COX-2) in normal epidermis induced by double application of TPA.
CONCLUSIONS:
The moracin was found protective influence in tumor promotion. Utilization of Moracin may open a new avenue in the treatment of tumerigenesis.
Moracin D Description
Source: The root barks of Morus alba L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2436 mL 16.218 mL 32.4359 mL 64.8719 mL 81.0898 mL
5 mM 0.6487 mL 3.2436 mL 6.4872 mL 12.9744 mL 16.218 mL
10 mM 0.3244 mL 1.6218 mL 3.2436 mL 6.4872 mL 8.109 mL
50 mM 0.0649 mL 0.3244 mL 0.6487 mL 1.2974 mL 1.6218 mL
100 mM 0.0324 mL 0.1622 mL 0.3244 mL 0.6487 mL 0.8109 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chem. Lett., 1978(11):1239-40.
Moracin C and D, new phytoalexins from diseased mulberry.[Reference: WebLink]

METHODS AND RESULTS:
Two antifungal compounds, moracin C and Moracin D, have been isolated from fungus-infected cortex and phloem tissues of mulberry shoots and their structures have been determined to be formulas 3 and 5 on the basis of the spectral and chemical evidence, respectively.
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