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Negundonorin A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Negundonorin A
Price:
CAS No.: 1401618-51-6
Catalog No.: CFN96848
Molecular Formula: C29H40O5
Molecular Weight: 468.63 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The seeds of Vitex negundo.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
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10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Negundonorin A is strongly cytotoxic against ZR-75-30 cell line with IC(50) value of 0.56 ± 0.19 ug/mL.
Negundonorin A Description
Source: The seeds of Vitex negundo.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1339 mL 10.6694 mL 21.3388 mL 42.6776 mL 53.347 mL
5 mM 0.4268 mL 2.1339 mL 4.2678 mL 8.5355 mL 10.6694 mL
10 mM 0.2134 mL 1.0669 mL 2.1339 mL 4.2678 mL 5.3347 mL
50 mM 0.0427 mL 0.2134 mL 0.4268 mL 0.8536 mL 1.0669 mL
100 mM 0.0213 mL 0.1067 mL 0.2134 mL 0.4268 mL 0.5335 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Fitoterapia. 2012 Jan;83(1):49-54.
Sesquiterpenoids and norterpenoids from Vitex negundo.[Pubmed: 21968063 ]

METHODS AND RESULTS:
Chemical investigation on the seeds of Vitex negundo has afforded a new furan-containing sesquiterpenoid, negunfurol (1), a new norlabdane-type diterpenoid, negundoal (2), and two new norursane-type triterpenoids, Negundonorin A (3) and negundonorin B (4), together with two know compounds, 3-formyl-4,5-dimethyl-8-oxo-5H-6,7-dihydronaphtho[2,3-b]furan (5) and 3-epi-corosolic acid (6). Their structures and configurations were elucidated by detailed spectroscopic analyses on the basis of NMR, IR, and MS data.
CONCLUSIONS:
Compound 3 was strongly cytotoxic against ZR-75-30 cell line with IC(50) value of 0.56 ± 0.19 μg/mL, whereas compound 1 was most active against HL-60 cell line with IC(50) value of 0.94 ± 0.26 μg/mL.
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Price: $218/10mg
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CAS No: 33390-42-0
Price: $318/5mg
Alpha-pinene

Catalog No: CFN93285
CAS No: 80-56-8
Price: $30/20mg
Physcion

Catalog No: CFN98848
CAS No: 521-61-9
Price: $40/20mg
Cyclo(Pro-Leu)

Catalog No: CFN90281
CAS No: 5654-86-4
Price: $238/10mg
10-Shogaol

Catalog No: CFN92300
CAS No: 36752-54-2
Price: $138/20mg
Magnolol

Catalog No: CFN98872
CAS No: 528-43-8
Price: $30/20mg
alpha-Carotene

Catalog No: CFN93610
CAS No: 7488-99-5
Price: $ / mg
1,2,3,6-Tetragalloylglucose

Catalog No: CFN00447
CAS No: 79886-50-3
Price: $238/10mg
Kaempferol-3-beta-O-glucuronide

Catalog No: CFN90359
CAS No: 22688-78-4
Price: $318/5mg
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