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Neotripterifordin
Neotripterifordin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Neotripterifordin
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CAS No.: 149249-32-1
Catalog No.: CFN89189
Molecular Formula: C20H30O3
Molecular Weight: 318.45 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The roots of Tripterygium wilfordii.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Our products had been exported to the following research institutions and universities, And still growing.
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  • Kyoto University (Japan)
  • Universitas Airlangga (Indonesia)
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Neotripterifordin shows potent anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 25 nM and TI of 125.
Targets: HIV
In vitro:
Bioorg Med Chem. 1995 Oct;3(10):1345-8.
Anti-AIDS agents--XIX. Neotripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation.[Pubmed: 8564400]

METHODS AND RESULTS:
A new kaurane type diterpene lactone, Neotripterifordin (1), has been isolated from the roots of Tripterygium wilfordii. The structure of 1 was elucidated by spectroscopic methods, which included the concerted application of a number of 2-D NMR techniques including 1H-1H COSY, phase-sensitive NOESY, HETCOR, and long-range HETCOR.
CONCLUSIONS:
Compound 1 showed potent anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 25 nM and TI of 125.
Neotripterifordin Description
Source: The roots of Tripterygium wilfordii.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1402 mL 15.7011 mL 31.4021 mL 62.8042 mL 78.5053 mL
5 mM 0.628 mL 3.1402 mL 6.2804 mL 12.5608 mL 15.7011 mL
10 mM 0.314 mL 1.5701 mL 3.1402 mL 6.2804 mL 7.8505 mL
50 mM 0.0628 mL 0.314 mL 0.628 mL 1.2561 mL 1.5701 mL
100 mM 0.0314 mL 0.157 mL 0.314 mL 0.628 mL 0.7851 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN98989ent-16beta,17-Isopropylidenedioxykaurane58493-71-3346.6 C23H38O2
CFN99267Sculponeatin N1169805-98-4404.6 C25H40O4
CFN99268Sculponeatin O1169806-00-1440.6 C28H40O4
CFN96482ent-17-Hydroxykaura-9(11),15-dien-19-oic acid1588516-88-4316.44C20H28O3
CFN97752ent-17-Hydroxykaur-15-en-19-oic acid35030-38-7318.46C20H30O3
CFN97033ent-Kauran-17,19-dioic acid60761-79-7334.5 C20H30O4
CFN96674Siegeskaurolic acid52645-97-3320.47C20H32O3
CFN98424ent-16beta,17-Dihydroxy-19-kauranoic acid3301-61-9336.5 C20H32O4
CFN95172ent-16beta,17-dihydroxy-9(11)-kauren-19-oic acid55483-24-4334.5C20H30O4
CFN97973Pterisolic acid F1401419-90-6366.5C20H30O6
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