Neritaloside | CAS:465-13-4 | Manufacturer ChemFaces

Neritaloside

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Description:

Neritaloside is a cardiac glycoside. Neritaloside exhibits central nervous system depressant activity in mice at a dose of 25 mg/kg.

Targets:

Sodium Channel | ATPase | Potassium Channel

In vitro:

Anal Chem. 2000 Aug 1;72(15):3547-52.

LC/MS/MS analyses of an oleander extract for cancer treatment.[Pubmed: 10952541]

METHODS AND RESULTS:
An HPLC/MS/MS method has been developed for the characterization and quantification of the cardiac glycosides oleandrin, odoroside, Neritaloside and the aglycone oleandrigenin, all contained in a patented-hot-water extract of Nerium oleander L (Anvirzel). Qualitative analysis of such extracts was achieved using a hybrid tandem quadrupole time-of-flight (QqTOF) mass spectrometer. Collision-induced dissociation (CID) mass spectra of oleandrin, oleandrigenin, odoroside, and Neritaloside were obtained with greater than 5 ppm mass accuracy and resolution routinely in excess of 8000 (fwhm). The detection limit for oleandrin of 20 pg (injected) was realized when the precursor-to-product ion transition, m/z 577 --> 373, was monitored.
CONCLUSIONS:
We have also applied the analytical method to the determination of oleandrin, oleandrigenin, Neritaloside, and odoroside in human plasma following an intramuscular injection of Anvirzel.

In vivo:

Phytochemistry. 1999 Feb;50(3):435-8.

Bio-active cardenolides from the leaves of Nerium oleander.[Pubmed: 9933955]

METHODS AND RESULTS:
A bioactivity directed isolation of the methanolic extract of the fresh, uncrushed leaves of Nerium oleander showing a central nervous system (CNS) depressant effect in mice has been undertaken. As a result, four CNS depressant cardenolides including a new cardenolide, neridiginoside and three known constituents, nerizoside, Neritaloside and odoroside-H, have been isolated which exhibited CNS depressant activity in mice at a dose of 25 mg/kg.
CONCLUSIONS:
The structure of neridiginoside was elucidated as 3 beta-O-(D-diginosyl)-5 beta, 14 beta-dihydroxy-card-20(22)-enolide, using spectroscopic methods including one-dimensional and two-dimensional NMR (COSY-45, NOESY, J-resolved, HMQC and HMBC). The known compounds have been indentified through spectral studies and comparison of data with those reported in the literature.

Neritaloside Description

Source:	The herbs of Nerium indicum Mill.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

J Ethnopharmacol. 2011 Apr 12;134(3):781-8.

Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum.[Pubmed: 21291990]

For identification of the active constituents we investigated the anticancer activity of cardenolides from Streptocaulon tomentosum Wight & Arn. (Asclepiadaceae) and from Nerium oleander L. (Apocynaceae) which are both used against cancer in the traditional medicine in their region of origin.
METHODS AND RESULTS:
The antiproliferative activity of cardenolides isolated from roots of Streptocaulon tomentosum (IC(50)<1-15.3 μM after 2 days in MCF7) and of cardenolide containing fractions from the cold aqueous extract of Nerium oleander leaves ("Breastin", mean IC(50) 0.85 μg/ml in a panel of 36 human tumor cell lines), their influence on the cellular viability and on the cell cycle (block at the G2/M-phase or at the S-phase in tumor cells, respectively) were determined using different cell lines. The murine cell line L929 and normal non-tumor cells were not affected. Bioactivity guided fractionation of Breastin resulted in the isolation of the monoglycosidic cardenolides oleandrine, oleandrigeninsarmentoside, Neritaloside, odoroside H, and odoroside A (IC(50)-values between 0.010 and 0.071 μg/ml).
CONCLUSIONS:
The observed anticancer activities of extracts and isolated cardenolides are in agreement with the ethnomedicinal use of Streptocaulon tomentosum and Nerium oleander. The most active anticancer compounds from both species are monoglycosidic cardenolides possessing the 3β,14β-dihydroxy-5β-card-20(22)-enolide structure with or without an acetoxy group at C-16. The results indicate that the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase.

Product Name	Neritaloside
Price:
CAS No.:	465-13-4
Catalog No.:	CFN98691
Molecular Formula:	C₃₂H₄₈O₁₀
Molecular Weight:	592.7 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The herbs of Nerium indicum Mill.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Cardiotonic Compound Library Steroids Compound Library Sodium Channel Inhibitor Library Potassium Channel Inhibitor Library ATPase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6872 mL	8.436 mL	16.8719 mL	33.7439 mL	42.1799 mL
5 mM	0.3374 mL	1.6872 mL	3.3744 mL	6.7488 mL	8.436 mL
10 mM	0.1687 mL	0.8436 mL	1.6872 mL	3.3744 mL	4.218 mL
50 mM	0.0337 mL	0.1687 mL	0.3374 mL	0.6749 mL	0.8436 mL
100 mM	0.0169 mL	0.0844 mL	0.1687 mL	0.3374 mL	0.4218 mL

CFN89202	Sarmentocymarin	98633-61-5	534.69	C₃₀H₄₆O₈
CFN89193	Cryptanoside A	98570-81-1	562.65	C₃₀H₄₂O₁₀
CFN97195	17alpha-Neriifolin	7044-31-7	534.7	C₃₀H₄₆O₈
CFN99868	Odoroside H	18810-25-8	534.7	C₃₀H₄₆O₈
CFN97718	Uzarigenin digitaloside	61217-80-9	534.69	C₃₀H₄₆O₈
CFN98691	Neritaloside	465-13-4	592.7	C₃₂H₄₈O₁₀
CFN98693	Oleandrin	465-16-7	576.7	C₃₂H₄₈O₉
CFN95876	Cryptostigmin II	50906-57-5	740.8	C₃₇H₅₆O₁₅
CFN99245	Thevebioside	114586-47-9	696.8	C₃₆H₅₆O₁₃
CFN99246	17alpha-Thevebioside	114613-59-1	696.8	C₃₆H₅₆O₁₃