| Structure Identification: |
| Nat Prod Commun. 2011 Dec;6(12):1889-92. | | Antifungal activity and isomerization of octadecyl p-coumarates from Ipomoea carnea subsp. fistulosa.[Pubmed: 22312731] |
METHODS AND RESULTS:
Bioassay monitored HPLC assisted isolation and purification of the chief antifungal fraction of the leaves of Ipomoea carnea subsp. fistulosa (Convulvulaceae) were achieved using Colletotrichum gloeosporioides and Cladosporium cucumerinum as test organisms. The activity of the purified fraction was further confirmed by the dose dependent inhibition of the spore germination of Alternaria alternata and A. porri. The active fraction was identified as a mixture of (E)-Octadecyl p-coumarate and (Z)-Octadecyl p-coumarate. The two isomers were detected on an HPLC column with substantially different retention times, but once eluted from the column, one form was partly converted to the other in daylight.
CONCLUSIONS:
Conclusive evidence for the structures and their isomerization were obtained from the HPLC behavior, IR, UV, HRESIMS, CIMS and and NMR spectral data. Important 1H NMR and 13C NMR signals could be separately assigned for the isomers using 2D NMR techniques. | | Zhongguo Zhong Yao Za Zhi. 2008 Mar;33(5):524-6. | | Chemical constituents from Hedyotis diffusa.[Pubmed: 18536374] | To investigate the chemical constituents from Hedyotis diffusa.
METHODS AND RESULTS:
The compounds were isolated and purified by various chromatographic techniques and identified by their physicochemical properties and spectral data. Eight compounds were isolated and identified as octadecyl (E)-p-coumarate ((E)-Octadecyl p-coumarate,1), p-E-methoxy-cinnamic acid (2), ferulic acid (3), scopoletin (4), succinic acid (5), aurantiamide acetate (6), rubiadin (7), robustaquinone D (8).
CONCLUSIONS:
Compounds 1-8 were obtained from genus Hedyotis for the first time. |
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