Pandamarilactonine A | CAS:303008-80-2

Pandamarilactonine A

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Description:

Pandamarilactonine A has antimicrobial activity, it is active with an MIC of 15.6 ug/mL and MBC of 31.25 ug/mL against Pseudomonas aeruginosa.

Targets:

Antifection

In vitro:

J. Appl. Pharm.Sci.,2015,5(10):151-3.

Antimicrobial alkaloids from the leaves of Pandanus amaryllifolius[Reference: WebLink]

METHODS AND RESULTS:
Chemical investigation on the crude base of the Pandanus amaryllifolius leaves led to the isolation and identification of pandamarilactone-1 (1), pandamarilactone-32 (2), Pandamarilactonine A (3), and pandamarilactonine B (4). Their structures were elucidated based on 1H and 13C NMR and in comparison with the literature data. Compound 3 was found to be the most active among the four isolates with an MIC of 15.6 ug/mL and MBC of 31.25 ug/mL against Pseudomonas aeruginosa.
CONCLUSIONS:
This is the first report on the antimicrobial activity of the isolated alkaloids from the genus Pandanus.

Pandamarilactonine A Description

Source:	The barks of Pandanus amaryllifolius
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Chem Pharm Bull (Tokyo). 2002 Sep;50(9):1303-4.

Isolation and structure elucidation of two new alkaloids, pandamarilactonine-C and -D, from Pandanus amaryllifolius and revision of relative stereochemistry of pandamarilactonine-A and -B by total synthesis.[Pubmed: 12237561]

METHODS AND RESULTS:
Two new pyrrolidine alkaloids, pandamarilactonine-C and -D, were isolated from Pandanus amaryllifolius.
CONCLUSIONS:
Based on the total synthesis of pandamarilactonine-C and its related alkaloid, Pandamarilactonine A, the relative stereochemistry of Pandamarilactonine A and -B, which was previously proposed by spectroscopic analysis, was revised.

Arch Pharm (Weinheim). 2008 Sep;341(9):578-83.

Diastereoselective synthesis of N-Boc-norpandamarilactonine-B and pandamarilactonine-A.[Pubmed: 18763717]

METHODS AND RESULTS:
Optically pure N-Boc-norpandamarilactonine-B was diastereoselectively synthesized starting from L-serine by employing a double ring closing metathesis (RCM) of a tetraene derivative as a key reaction. N-Boc-norpandamarilactonine-B obtained was further converted to Pandamarilactonine A.

Product Name	Pandamarilactonine A
Price:
CAS No.:	303008-80-2
Catalog No.:	CFN98380
Molecular Formula:	C₁₈H₂₃NO₄
Molecular Weight:	317.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The barks of Pandanus amaryllifolius
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Alkaloids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1506 mL	15.753 mL	31.506 mL	63.012 mL	78.765 mL
5 mM	0.6301 mL	3.1506 mL	6.3012 mL	12.6024 mL	15.753 mL
10 mM	0.3151 mL	1.5753 mL	3.1506 mL	6.3012 mL	7.8765 mL
50 mM	0.063 mL	0.3151 mL	0.6301 mL	1.2602 mL	1.5753 mL
100 mM	0.0315 mL	0.1575 mL	0.3151 mL	0.6301 mL	0.7876 mL

CFN98380	Pandamarilactonine A	303008-80-2	317.4	C₁₈H₂₃NO₄
CFN98381	Pandamarilactonine B	303008-81-3	317.4	C₁₈H₂₃NO₄