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Paprazine
Paprazine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Paprazine
Price: $268 / 10mg
CAS No.: 36417-86-4
Catalog No.: CFN92967
Molecular Formula: C17H17NO3
Molecular Weight: 283.32 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Polygonum orientale.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $90.1 / In-stock
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Paprazine may have cytotoxic activity.
In vitro:
Zhongguo Zhong Yao Za Zhi. 2018 Apr;43(8):1654-1661.
Chemical constituents from roots of Datura metel.[Pubmed: 29751713]
To study the flavonoids of Scutellaria baicalensis and their bioactivities.
METHODS AND RESULTS:
Chromatographic methods were used to separate compounds, spectral methods were used to determine the structures and bioactivities of the flavonoids were screened in several models in vitro. Nine compounds were isolated and identified as baicalein (1), wogonin (2), oroxylin A (3), 5, 7, 2', 6'-tetrahydroxyflavone (4), viscidulin III (5), baicalin (6), wogonoside (7), oroxylin A-7-O-beta-D-glucuronide (8) and chrysin-6-C-alpha-L-arabinopyranosyl-8-C-beta-D-glucopyranoside (9).
CONCLUSIONS:
Baicalein had good anti-bacteria activity, and some compounds showed inhibiting activity against IL-1beta converting enzyme. The 13C NMR data of compounds 9 were assigned correctly by 2D nuclear magnetic resonance (NMR).
Paprazine Description
Source: The herbs of Polygonum orientale.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5296 mL 17.6479 mL 35.2958 mL 70.5916 mL 88.2394 mL
5 mM 0.7059 mL 3.5296 mL 7.0592 mL 14.1183 mL 17.6479 mL
10 mM 0.353 mL 1.7648 mL 3.5296 mL 7.0592 mL 8.8239 mL
50 mM 0.0706 mL 0.353 mL 0.7059 mL 1.4118 mL 1.7648 mL
100 mM 0.0353 mL 0.1765 mL 0.353 mL 0.7059 mL 0.8824 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Nat Prod Res. 2009;23(15):1416-23.
Alkaloids from Piper sarmentosum and Piper nigrum.[Pubmed: 19809914 ]
Detailed chemical studies on the roots of Piper sarmentosum and Piper nigrum have resulted in several alkaloids.
METHODS AND RESULTS:
The roots of P. sarmentosum gave a new aromatic compound, 1-nitrosoimino-2,4,5-trimethoxybenzene (1). Piper nigrum roots gave pellitorine (2), (E)-1-[3',4'-(methylenedioxy)cinnamoyl]piperidine (3), 2,4-tetradecadienoic acid isobutyl amide (4), piperine (5), sylvamide (6), cepharadione A (7), piperolactam D (8) and Paprazine (9). Structural elucidation of these compounds was achieved through NMR and MS techniques.
CONCLUSIONS:
Cytotoxic activity screening of the plant extracts indicated some activity.
CFN92966Tamgermanetin640235-90-1313.35C18H19NO4
CFN92826Cis-N-Feruloyltyramine80510-09-4313.4C18H19NO4
CFN97707N-Feruloyloctopamine66648-44-0329.35C18H19NO5
CFN95768cis-N-Feruloyloctopamine180050-83-3329.4C18H19NO5
CFN97809Cannabisin F163136-19-4624.69C36H36N2O8
CFN95286Lyciumamide B1647111-41-8624.7C36H36N2O8
CFN94001Cannabisin H403647-08-5509.55C28H31NO8
CFN93215Kukoamine A 75288-96-9530.7C28H42N4O6
CFN93216Kukoamine B164991-67-7530.7C28H42N4O6
CFN98937Asperglaucide56121-42-7444.5 C27H28N2O4
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