Parishin A | CAS:62499-28-9 | Manufacturer ChemFaces

Parishin A

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $19.5 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Chrysosplenetin

Catalog No: CFN97026
CAS No: 603-56-5
Price: $138/20mg

11-Hydroxy-sugiol

Catalog No: CFN90366
CAS No: 88664-08-8
Price: $490/5mg

Dioscin

Catalog No: CFN99516
CAS No: 19057-60-4
Price: $40/20mg

4',5,6,7-Tetramethoxyflavone

Catalog No: CFN91034
CAS No: 1168-42-9
Price: $258/5mg

Sesamin

Catalog No: CFN97034
CAS No: 607-80-7
Price: $40/20mg

Epigoitrin

Catalog No: CFN99521
CAS No: 1072-93-1
Price: $100/20mg

3-Isomangostin

Catalog No: CFN99724
CAS No: 19275-46-8
Price: $168/10mg

Calycosin

Catalog No: CFN99140
CAS No: 20575-57-9
Price: $80/20mg

Squalene

Catalog No: CFN99208
CAS No: 111-02-4
Price: $30/20mg

Gypenoside XLIX

Catalog No: CFN99717
CAS No: 94987-08-3
Price: $118/20mg

Description:

Parishin A has good neuroprotective effects against brain disorders.

In vitro:

Oxid Med Cell Longev . 2016;2016:4074690.

Parishin from Gastrodia elata Extends the Lifespan of Yeast via Regulation of Sir2/Uth1/TOR Signaling Pathway[Pubmed: 27429709]

Abstract Parishin is a phenolic glucoside isolated from Gastrodia elata, which is an important traditional Chinese medicine; this glucoside significantly extended the replicative lifespan of K6001 yeast at 3, 10, and 30 μM. To clarify its mechanism of action, assessment of oxidative stress resistance, superoxide dismutase (SOD) activity, malondialdehyde (MDA), and reactive oxygen species (ROS) assays, replicative lifespans of sod1, sod2, uth1, and skn7 yeast mutants, and real-time quantitative PCR (RT-PCR) analysis were conducted. The significant increase of cell survival rate in oxidative stress condition was observed in parishin-treated groups. Silent information regulator 2 (Sir2) gene expression and SOD activity were significantly increased after treating parishin in normal condition. Meanwhile, the levels of ROS and MDA in yeast were significantly decreased. The replicative lifespans of sod1, sod2, uth1, and skn7 mutants of K6001 yeast were not affected by parishin. We also found that parishin could decrease the gene expression of TORC1, ribosomal protein S26A (RPS26A), and ribosomal protein L9A (RPL9A) in the target of rapamycin (TOR) signaling pathway. Gene expression levels of RPS26A and RPL9A in uth1, as well as in uth1, sir2 double mutants, were significantly lower than those of the control group. Besides, TORC1 gene expression in uth1 mutant of K6001 yeast was inhibited significantly. These results suggested that parishin exhibited antiaging effects via regulation of Sir2/Uth1/TOR signaling pathway.

Parishin A Description

Source:	The rhizomes of Gastrodia elata
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Chinese Journal of Experimental Traditional Medical Formulae, 2016, (18) :5-8.

Comparison on Chemical Constituents and Pharmacological Effect of Gastrodiae Rhizoma Between Traditional Processing and Integration Processing[Reference: WebLink]

To elucidate the rationality of integration processing technology based on comparison on chemical constituents and pharmacological effect of Gastrodiae Rhizoma between traditional processing and integration processing.
METHODS AND RESULTS:
Taking contents of gastrodin and parishins as indexes,chemical constituents difference in Gastrodiae Rhizoma between traditional processing and integration processing was compared,effects of Gastrodiae Rhizoma on eclampsia model induced by pentylenetetrazole were observed to compare products with different processing technology. Contents of gastrodin,Parishin A,parishin B,parishin C and parishin E in products of integration processing were 0. 79%,2. 04%,0. 91%,0. 23% and0. 57%,they were 0. 39%,1. 12%,0. 64%,0. 15% and 0. 54% in products of traditional processing. The anti-eclampsia effect of Gastrodiae Rhizoma produced with integrated processing technology was better thantraditional processing technology.
CONCLUSIONS:
Compared with the traditional processing technology, the integrated processing technology is better in guaranteeing the quality of pieces,reducing the cost of production and increasing the production efficiency.

Product Name	Parishin A
Price:	$50 / 20mg
CAS No.:	62499-28-9
Catalog No.:	CFN93112
Molecular Formula:	C₄₅H₅₆O₂₅
Molecular Weight:	996.9 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The rhizomes of Gastrodia elata
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.0031 mL	5.0155 mL	10.0311 mL	20.0622 mL	25.0777 mL
5 mM	0.2006 mL	1.0031 mL	2.0062 mL	4.0124 mL	5.0155 mL
10 mM	0.1003 mL	0.5016 mL	1.0031 mL	2.0062 mL	2.5078 mL
50 mM	0.0201 mL	0.1003 mL	0.2006 mL	0.4012 mL	0.5016 mL
100 mM	0.01 mL	0.0502 mL	0.1003 mL	0.2006 mL	0.2508 mL

CFN93114	Parishin C	174972-80-6	728.7	C₃₂H₄₀O₁₉
CFN93112	Parishin A	62499-28-9	996.9	C₄₅H₅₆O₂₅
CFN90409	Militarine	58139-23-4	726.73	C₃₄H₄₆O₁₇
CFN95032	Dactylorhin A	256459-34-4	888.9	C₄₀H₅₆O₂₂
CFN95033	Gymnoside III	899430-03-6	930.9	C₄₂H₅₈O₂₃
CFN95061	Shancigusin I	1435488-35-9	594.6	C₂₈H₃₄O₁₄
CFN91183	Bletilloside A	2292159-89-6	624.6	C₂₉H₃₆O₁₅
CFN95062	3-Methoxyshancigusin I	N/A	624.6	C₂₉H₃₆O₁₅
CFN93274	Salicylic acid	69-72-7	138.12	C₇H₆O₃
CFN98978	2-Acetylbenzoic acid	577-56-0	164.2	C₉H₈O₃