Periglaucine A | CAS:1025023-04-4 | Manufacturer ChemFaces

Periglaucine A

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Description:

Periglaucine A inhibits hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells.

Targets:

HBV

In vitro:

J Nat Prod. 2008 May;71(5):760-3.

Periglaucines A-D, anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus.[Pubmed: 18396905]

METHODS AND RESULTS:
Four new hasubanane-type alkaloids, periglaucines A-D (1-4), and three known alkaloids, norruffscine (5), (-)-8-oxotetrahydropalmatine (6), and (-)-8-oxocanadine (7), were isolated from the aerial parts of Pericampylus glaucus. Their structures were elucidated on the basis of extensive NMR and EIMS data, and that of Periglaucine A (1) was confirmed by single-crystal X-ray diffraction.
CONCLUSIONS:
Alkaloids 1-4 inhibited hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells. (-)-8-Oxotetrahydropalmatine (6) possessed a high selectivity index (SI = 22.4) for HBsAg secretion of the Hep G2.2.15 cell line with an IC(50) value of 0.14 mM. Norruffscine (5) and (-)-8-oxotetrahydropalmatine (6) exhibited inhibitory activity against human immunodeficiency virus (HIV-1) with EC(50) values of 10.9 and 14.1 microM in C8166 cells (SI = 45.7 and 18.8), respectively.

Periglaucine A Description

Source:	The aerial parts of Pericampylus glaucus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Periglaucine A
Price:
CAS No.:	1025023-04-4
Catalog No.:	CFN99040
Molecular Formula:	C₂₀H₂₃NO₆
Molecular Weight:	373.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The aerial parts of Pericampylus glaucus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antiviral Compound Library Alkaloids Compound Library HBV Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6781 mL	13.3905 mL	26.7809 mL	53.5619 mL	66.9523 mL
5 mM	0.5356 mL	2.6781 mL	5.3562 mL	10.7124 mL	13.3905 mL
10 mM	0.2678 mL	1.339 mL	2.6781 mL	5.3562 mL	6.6952 mL
50 mM	0.0536 mL	0.2678 mL	0.5356 mL	1.0712 mL	1.339 mL
100 mM	0.0268 mL	0.1339 mL	0.2678 mL	0.5356 mL	0.6695 mL

CFN98830	Oxoepistephamiersine	51804-68-3	403.4	C₂₁H₂₅NO₇
CFN98856	Epistephamiersine	52389-15-8	389.5	C₂₁H₂₇NO₆
CFN99040	Periglaucine A	1025023-04-4	373.4	C₂₀H₂₃NO₆
CFN96748	Periglaucine B	1025023-05-5	373.40	C₂₀H₂₃NO₆
CFN99508	Sinomenine	115-53-7	329.38	C₁₉H₂₃NO₄
CFN99561	Sinomenine HCl	6080-33-7	365.85	C₁₉H₂₃NO₄.HCl
CFN95807	Sinomenine N-oxide	1000026-77-6	345.4	C₁₉H₂₃NO₅
CFN92332	Fenfangjine G	205533-81-9	433.5	C₂₂H₂₇NO₈
CFN98993	16-Oxoprometaphanine	58738-31-1	373.4	C₂₀H₂₃NO₆
CFN97167	Prometaphanine	6858-85-1	359.4	C₂₀H₂₅NO₅