Perillyl alcohol | CAS:536-59-4 | Manufacturer ChemFaces

Perillyl alcohol

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Size /Price /Stock	10 mM * 1 mL in DMSO / $7.0 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Perillyl alcohol has potential chemopreventive, and antileukemia activities, it can suppress antigen-induced immune responses in the lung, it could be a novel preventive or therapeutic option for immunologic lung disorders such as asthma with minimal side effects. Perillyl alcohol can suppress antigen-induced immune responses in the lung, it could be a novel preventive or therapeutic option for immunologic lung disorders such as asthma with minimal side effects.

Targets:

AP-1 | TNF-α | NF-kB | gp120/CD4

In vivo:

Int. Res., 2002, 443(5):266-71.

Perillyl alcohol suppresses antigen-induced immune responses in the lung.[Pubmed: 24309112 ]

Perillyl alcohol (POH) is an isoprenoid which inhibits farnesyl transferase and geranylgeranyl transferase, key enzymes that induce conformational and functional changes in small G proteins to conduct signal production for cell proliferation. Thus, it has been tried for the treatment of cancers. However, although it affects the proliferation of immunocytes, its influence on immune responses has been examined in only a few studies. Notably, its effect on antigen-induced immune responses has not been studied.
METHODS AND RESULTS:
In this study, we examined whether POH suppresses Ag-induced immune responses with a mouse model of allergic airway inflammation. POH treatment of sensitized mice suppressed proliferation and cytokine production in Ag-stimulated spleen cells or CD4(+) T cells. Further, sensitized mice received aerosolized OVA to induce allergic airway inflammation, and some mice received POH treatment. POH significantly suppressed indicators of allergic airway inflammation such as airway eosinophilia. Cytokine production in thoracic lymph nodes was also significantly suppressed.
CONCLUSIONS:
These results demonstrate that POH suppresses antigen-induced immune responses in the lung. Considering that it exists naturally, POH could be a novel preventive or therapeutic option for immunologic lung disorders such as asthma with minimal side effects.

Perillyl alcohol Description

Source:	The herbs of Cymbopogon citratus.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Cancer Res., 1998, 58(4):711-6.

Inhibitory effects of perillyl alcohol on UVB-induced murine skin cancer and AP-1 transactivation.[Pubmed: 9485025]

The monoterpene Perillyl alcohol (POH) has proven efficacious against the formation and progression of a variety of cancers.
METHODS AND RESULTS:
In this study, we tested the ability of POH to inhibit photocarcinogenesis in a nonmelanoma model of mouse skin carcinogenesis and its ability to inhibit UVB-induced activator protein 1 (AP-1) transactivation in mouse skin and human keratinocytes. POH (10 mM) was applied topically to the ears and shaved dorsal surface of groups of 35 BALB/c mice throughout the experiment, during and after UVB treatment. Topical POH significantly inhibited tumor incidence and multiplicity, average tumor size, and the average tumor burden/mouse without any apparent toxicity. POH inhibited UVB-induced AP-1 transactivation in both cultured human keratinocytes and transgenic mice that stably express a luciferase reporter driven by AP-1 elements.
CONCLUSIONS:
The results suggest that POH might be used for chemoprevention of human skin cancer, and that inhibition of AP-1 activity is functionally related to inhibition of skin carcinogenesis.

Product Name	Perillyl alcohol
Price:	$30 / 20mg
CAS No.:	536-59-4
Catalog No.:	CFN93581
Molecular Formula:	C₁₀H₁₆O
Molecular Weight:	152.2 g/mol
Purity:	>=98%
Type of Compound:	Monoterpenoids
Physical Desc.:	Oil
Source:	The herbs of Cymbopogon citratus.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Hepatoprotective Compound Library Cancer chemoprevention Compound Library Anti-photoaging Compound Library Antileukaemic Compound Library Anti-metastatic Compound Library Immunosuppression Compound Library Monoterpenoids Compound Library TNF-α Inhibitor Library NF-kB Inhibitor Library gp120/CD4 Inhibitor Library AP-1 Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.5703 mL	32.8515 mL	65.703 mL	131.406 mL	164.2576 mL
5 mM	1.3141 mL	6.5703 mL	13.1406 mL	26.2812 mL	32.8515 mL
10 mM	0.657 mL	3.2852 mL	6.5703 mL	13.1406 mL	16.4258 mL
50 mM	0.1314 mL	0.657 mL	1.3141 mL	2.6281 mL	3.2852 mL
100 mM	0.0657 mL	0.3285 mL	0.657 mL	1.3141 mL	1.6426 mL

CFN97032	2-Hydroxy-1,8-cineole	60761-00-4	170.3	C₁₀H₁₈O₂
CFN92688	Terpineol	98-55-5	154.3	C₁₀H₁₈O
CFN80110	Alpha-Terpineol	10482-56-1	154.25	C₁₀H₁₈O
CFN94877	Terpinine-4-ol	562-74-3	154.3	C₁₀H₁₈O
CFN97064	p-Menthane-1,2,8-triol	62014-81-7	188.3	C₁₀H₂₀O₃
CFN99656	p-Menthane-1,3,8-triol	155348-06-4	188.3	C₁₀H₂₀O₃
CFN98795	Oleuropeic acid	5027-76-9	184.2	C₁₀H₁₆O₃
CFN93581	Perillyl alcohol	536-59-4	152.2	C₁₀H₁₆O
CFN96125	Oleuropeic acid 8-O-glucoside	865887-46-3	346.4	C₁₆H₂₆O₈
CFN99285	Cuniloside B	1187303-40-7	512.6	C₂₆H₄₀O₁₀