Picrasidine I | CAS:100234-59-1 | Manufacturer ChemFaces

Picrasidine I

ChemFaces products have been cited in many studies from excellent and top scientific journals

Product Name	Picrasidine I
Price:	$368 / 5mg
CAS No.:	100234-59-1
Catalog No.:	CFN99019
Molecular Formula:	C₁₄H₁₂N₂O₂
Molecular Weight:	240.3 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Yellow powder
Source:	The barks of Picrasma quassioides.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $257.6 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Picrasidine I Description

Source:	The barks of Picrasma quassioides.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Cellular Physiology & Biochemistry, 2017:1425-1435.

Picrasidine I from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL Induced Signaling Pathways and Attenuation of ROS Production.[Reference: WebLink]

Osteoporosis is a metabolic bone disorder that tortures about millions of people worldwide. Recent study demonstrated agents derived from picrasma quassioides is a promising drug for targets multiple signaling pathways. However its potential in treatment of bone loss has not been fully understood.
METHODS AND RESULTS:
The bone marrow macrophages (BMMs) were cultured and induced with M-CSF and RANKL followed by Picrasidine I (PI) treatment. Then the effects of PI on osteoclast formation were evaluated by counting tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells. Moreover, effects of PI on bone resorption activity of mature osteoclast were studied through bone resorption pit counting and actin ring structure analysis. Further, the involved potential signaling pathways cross-talking were investigated by performed Western blotting and quantitative real-time PCR examination. Results demonstrated PI strongly inhibited RANKL induced osteoclast formation from its precursors. Mechanistically, the inhibitory effect of PI on osteoclast differentiation was due to the suppression of osteoclastogenic transcription factors, c-Fos and NFATc1. Moreover, PI markedly blocked the RANKL-induced osteoclastogenesis by attenuating MAPKs and NF-κB signaling pathways. In addition, PI decreased the ROS generation in osteoclast and osteoblast.
CONCLUSIONS:
Taken together our data demonstrate that PI has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library ROS Inhibitor Library MAPK Inhibitor Library

Description:	Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors.
Targets:	MAPK \| NF-κB \| ROS \| c-Fos \| NFATc1

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.1615 mL	20.8073 mL	41.6146 mL	83.2293 mL	104.0366 mL
5 mM	0.8323 mL	4.1615 mL	8.3229 mL	16.6459 mL	20.8073 mL
10 mM	0.4161 mL	2.0807 mL	4.1615 mL	8.3229 mL	10.4037 mL
50 mM	0.0832 mL	0.4161 mL	0.8323 mL	1.6646 mL	2.0807 mL
100 mM	0.0416 mL	0.2081 mL	0.4161 mL	0.8323 mL	1.0404 mL

CFN92929	4-Hydroxy-1-methoxycarbonyl-beta-carboline	74690-72-5	242.23	C₁₃H₁₀N₂O₃
CFN97037	4-Methoxy-1-methoxycarbonyl-beta-carboline	60807-25-2	256.3	C₁₄H₁₂N₂O₃
CFN98313	Crenatine	26585-14-8	226.3	C₁₄H₁₄N₂O
CFN99019	Picrasidine I	100234-59-1	240.3	C₁₄H₁₂N₂O₂
CFN99020	Picrasidine J	100234-62-6	242.3	C₁₄H₁₄N₂O₂
CFN97116	Dehydrocrenatidine	65236-62-6	254.3	C₁₅H₁₄N₂O₂
CFN92122	1-Acetyl-beta-carboline	50892-83-6	210.2	C₁₃H₁₀N₂O
CFN98456	1-Methoxycarbonyl-beta-carboline	3464-66-2	226.2	C₁₃H₁₀N₂O₂
CFN91567	1-Formyl-beta-carboline	20127-63-3	196.2	C₁₂H₈N₂O
CFN95291	Perlolyrine	29700-20-7	264.3	C₁₆H₁₂N₂O₂