Picroside IV | CAS:211567-04-3 | Manufacturer ChemFaces

Picroside IV

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Size /Price /Stock	10 mM * 1 mL in DMSO / $229.0 / In-stock
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Description:

Kutkoside is a mixture of iridoid glycosides namely, picroside II, Picroside IV and 6-ferulloylcatalpol, it may have antinociceptive and anti-inflammatory effects.

In vitro:

Indian J Exp Biol. 2010 Mar;48(3):323-8.

Online HPLC-DPPH method for antioxidant activity of Picrorhiza kurroa Royle ex Benth. and characterization of kutkoside by ultra-performance LC-electrospray ionization quadrupole time-of-flight mass spectrometry.[Pubmed: 21046989]

Picrorhiza kurroa Royle ex Benth., is widely used in the Indian systems of medicine for the treatment of various liver ailments.
METHODS AND RESULTS:
Since, the role of oxidative stress in the pathogenesis of liver injury has become generally recognized, in present study the free radical scavenging effect of P. kurroa was assessed by on-line HPLC-DPPH and colorimetric DPPH methods. The comparative study on antioxidant activity of P. kurroa extracts by both methods revealed that colorimetric method showed very less free radical scavenging effect while HPLC-DPPH method showed high activity. Further, the kutkoside, an important ingredient of a potent hepatoprotective formulation "kutkin/picroliv" was investigated for its chemical composition by ultra-performance liquid chromatography coupled with diode array detection/electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-DAD/ESI-QTOF-MS).
CONCLUSIONS:
Kutkoside was considered to be a single compound and reported as picroside-II or kutkoside, however, present investigation illustrated that kutkoside is a mixture of iridoid glycosides namely, picroside II, Picroside IV and 6-ferulloylcatalpol.

In vivo:

Z Naturforsch C. 2007 Nov-Dec;62(11-12):813-20.

Antinociceptive and anti-inflammatory effects of saponin and iridoid glycosides from Verbascum pterocalycinum var. mutense Hub.-Mor.[Pubmed: 18274283]

The anti-inflammatory and antinociceptive properties of four major compounds from the flowers of Verbascum pterocalycinum var. mutense were investigated. Saponin glycosides called ilwensisaponin A and C and iridoid glycosides known as ajugol and Picroside IV were isolated from the methanolic extract.
METHODS AND RESULTS:
A dose-related anti-inflammatory and antinociceptive response were obtained in this study at doses of 100 and 200 mg/kg. The results of the evaluation of the anti-inflammatory activity induced by carrageenan and PGE1 showed that this species possesses active constituents that could diminish the cyclooxygenase activitiy. No effects were observed in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema model.
CONCLUSIONS:
Our results support the anti-inflammatory and analgesic effects of Verbascum pterocalycinum var. mutense. Ilwensisaponins A and C could explain in part the anti-inflammatory and analgesic activities of this species. Although antinociceptive and anti-inflammatory activities of ajugol and Picroside IV were found insignificant in the statistical analysis, ilwensisaponin A and C showed notable activity without inducing any apparent acute toxicity as well as gastric damage.

Picroside IV Description

Source:	The roots of Picrorhiza scrophulariiflora
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Picroside IV
Price:	$318 / 10mg
CAS No.:	211567-04-3
Catalog No.:	CFN90868
Molecular Formula:	C₂₄H₂₈O₁₂
Molecular Weight:	508.50 g/mol
Purity:	>=98%
Type of Compound:	Iridoids
Physical Desc.:	Powder
Source:	The roots of Picrorhiza scrophulariiflora
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Iridoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9666 mL	9.8328 mL	19.6657 mL	39.3314 mL	49.1642 mL
5 mM	0.3933 mL	1.9666 mL	3.9331 mL	7.8663 mL	9.8328 mL
10 mM	0.1967 mL	0.9833 mL	1.9666 mL	3.9331 mL	4.9164 mL
50 mM	0.0393 mL	0.1967 mL	0.3933 mL	0.7866 mL	0.9833 mL
100 mM	0.0197 mL	0.0983 mL	0.1967 mL	0.3933 mL	0.4916 mL

CFN99428	6-O-Cinnamoylcatalpol	136807-41-5	492.5	C₂₄H₂₈O₁₁
CFN99565	Picroside I	27409-30-9	492.47	C₂₄H₂₈O₁₁
CFN97207	Specioside	72514-90-0	508.5	C₂₄H₂₈O₁₂
CFN99335	6-O-p-Methoxycinnamoylcatalpol	121710-02-9	522.5	C₂₅H₃₀O₁₂
CFN98809	Verminoside	50932-19-9	524.5	C₂₄H₂₈O₁₃
CFN97255	6-Feruloylcatalpol	770721-33-0	538.5	C₂₅H₃₀O₁₃
CFN98811	Minecoside	51005-44-8	538.5	C₂₅H₃₀O₁₃
CFN99611	6-O-(3'',4''-Dimethoxycinnamoyl)catalpol	147714-71-4	552.5	C₂₆H₃₂O₁₃
CFN90868	Picroside IV	211567-04-3	508.50	C₂₄H₂₈O₁₂
CFN99567	Picroside III	64461-95-6	538.50	C₂₅H₃₀O₁₃