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Piperitol
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Product Name Piperitol
Price:
CAS No.: 52151-92-5
Catalog No.: CFN96060
Molecular Formula: C20H20O6
Molecular Weight: 356.4 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The fruits of Myristica fragrans
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Piperitol has in vitro antioxidant potential, it also exhibits a stronger CNS depressant effect than that of M. rotundifolia.
In vitro:
Phytotherapy Research, 2010, 4(6):232-234.
CNS activity of Mentha rotundifolia and Mentha longifolia essential oil in mice and rats.[Reference: WebLink]

METHODS AND RESULTS:
The essential oils of Mentha rotundifolia and Mentha longifolia were analyzed with GC and GC/MS. The major components were rotundifolone (10.4%) and Piperitol (57.6%) in M. rotundifolia , and rotundifolone (33.2%) and diosphenol (47.7%) in M. longifolia. M. longifolia essential oil exhibited a stronger CNS depressant effect than that of M. rotundifolia ; both essential oils were somnifacients.
Journal of Agricultural and Food Chemistry, 2011, 59(7):3214-3219.
Identification of Methanol-Soluble Compounds in Sesame and Evaluation of Antioxidant Potential of Its Lignans.[Reference: WebLink]
The methanol extract of sesame (Sesamum indicum) seeds was fractionated and purified with the assistance of conventional column chromatography to afford 29 compounds including seven furofuran lignans. Among these isolates, (+)-samin (1) was obtained from the natural source for the first time. In addition, (-)-asarinin (30) and sesamol (31) were generated by oxidative derivation from (+)-sesamolin (2) and (+)-sesamin (3), two abundant lignans found in sesame seeds.
METHODS AND RESULTS:
To evaluate their in vitro antioxidant potential, the seven isolated lignans (1-7) and the two derivatives (30 and 31) were examined for the scavenging activities on DPPH free radicals and superoxide anions. Moreover, the capability of chelating ferrous ions and reducing power of these sesame lignans were also measured.
CONCLUSIONS:
The results suggest that, besides the well-known sesamolin and sesamin, the minor sesame lignans (+)-(7S,8'R,8R)-acuminatolide (5), (-)-Piperitol (6), and (+)-pinoresinol (7) are also adequate active ingredients and may be potential sources for nutritional and pharmacological utilization.
Piperitol Description
Source: The fruits of Myristica fragrans
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

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Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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IF=13.903(2019)

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Nature Plants. 2016 Dec 22;3: 16206.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8058 mL 14.0292 mL 28.0584 mL 56.1167 mL 70.1459 mL
5 mM 0.5612 mL 2.8058 mL 5.6117 mL 11.2233 mL 14.0292 mL
10 mM 0.2806 mL 1.4029 mL 2.8058 mL 5.6117 mL 7.0146 mL
50 mM 0.0561 mL 0.2806 mL 0.5612 mL 1.1223 mL 1.4029 mL
100 mM 0.0281 mL 0.1403 mL 0.2806 mL 0.5612 mL 0.7015 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chinese Traditional and Herbal Drugs, 2009, 40(10):1536-1539.
Chemical constituents in leaves of Piper laetispicum.[Reference: WebLink]
To study the chemical constituents in the leaves of Piper laetispicum.
METHODS AND RESULTS:
Compounds were separated and purified by silica gel column and macroporous resin. Their structures were identified on the basis of spectral methods. Sixteen compounds were isolated and identified from the leaves of P. laetispicum: (2E, 4E)-N-isobutyl-11-phenylundecadienamide (I), (2E, 4E)-N-isobutyl-15-phenylpentadecadienamide (II). laetispicine (III), (2E, 4E)-N-isobutyl-7-(3′ 4′-methylene-dioxyphenyl) heptadienamide ( IV ) , brachystamide A(V), dihydropipercide ( VI ), pipermacramide A [(2E, 4E)-N-isobutyleicosadienamide, VI], ( + )-spathulenol (VIII), d-sesamin (IX), Piperitol (X), vitexin(XI), vitexin-2″-O-β-D-glucoside (XII), N-p-coumaroyltyramine (XIII), β-sitosterol (XIV), stigmasterol (XV), and 1-dotriacontanol (XVI).
CONCLUSIONS:
Compounds I and II are isolated for the first time as natural substance, compounds V , VI, and VIII are first isolated from P. laetispicum, compounds XI , XII , and XVI are obtained from the plants of Piper L. for the first time.
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