Science | Nature | Cell | View More
Natural Products
Plathymenin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Plathymenin
Price:
CAS No.: 492-12-6
Catalog No.: CFN96496
Molecular Formula: C15H12O6
Molecular Weight: 288.25 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The herbs of Spatholobus suberectus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Donald Danforth Plant Science C... (USA)
  • University of South Australia (Australia)
  • Indian Institute of Science (India)
  • Stanford University (USA)
  • Sri Ramachandra University (India)
  • Instituto de Investigaciones Ag... (Chile)
  • Gyeongsang National University (Korea)
  • Universidad de Buenos Aires (Argentina)
  • University of Eastern Finland (Finland)
  • Georgia Institute of Technology (USA)
  • Martin Luther University of Hal... (Germany)
  • More...
Package
Featured Products
Stevioside

Catalog No: CFN99548
CAS No: 57817-89-7
Price: $40/20mg
N1,N10-Bis(p-coumaroyl)spermidine

Catalog No: CFN99248
CAS No: 114916-05-1
Price: $ /
Guaiol

Catalog No: CFN96326
CAS No: 489-86-1
Price: $ / mg
2-Amino-3-carboxy-1,4-naphthoquinone

Catalog No: CFN91040
CAS No: 173043-38-4
Price: $388/5mg
Protodioscin

Catalog No: CFN99517
CAS No: 55056-80-9
Price: $50/20mg
Momordicoside K

Catalog No: CFN92305
CAS No: 81348-84-7
Price: $ / mg
24-Methylenecycloartan-3-ol

Catalog No: CFN99496
CAS No: 1449-09-8
Price: $ /
Ganoderic acid D

Catalog No: CFN90292
CAS No: 108340-60-9
Price: $338/20mg
Mangiferin

Catalog No: CFN98719
CAS No: 4773-96-0
Price: $40/20mg
Corynoxeine

Catalog No: CFN98154
CAS No: 630-94-4
Price: $148/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Plathymenin is a natural product from Spatholobus suberectus.
In vitro:
Phytochemistry. 2006 Jun;67(12):1262-70.
Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells.[Pubmed: 16782143 ]
Of these constituents 3',4',7-trihydroxyflavone (1), eriodictyol (3), Plathymenin (5), dihydroquercetin (6), butin (7), neoisoliquiritigenin (8), dihydrokaempferol (9), liquiritigenin (10), and 6-methoxyeriodictyol (12) represented compounds isolated for the first time from S. suberectus.
METHODS AND RESULTS:
These constituents were evaluated their ability to inhibit cellular tyrosinase activity and for their melanin inhibitory activity in human epidermal melanocytes (HEMn). Butin (7) was the most efficacious of these constituents and exhibited concentration-dependent effects. Western blot analysis revealed that expression of tyrosinase and tyrosinase-related proteins 1 and 2 (TRP1 and TRP2) was decreased in butin (7)-treated HEMn cells. Additionally, quantitative real-time PCR (qRT-PCR) analysis disclosed that expression of mRNAs for tyrosinase, TRP1 and TRP2 was suppressed by butin (7).
CONCLUSIONS:
It is concluded that butin (7) is the most active of the components of S. suberectus in inhibiting pigmentation and that this inhibition is exerted through inhibition of transcription of the genes encoding tyrosinase, TRP1 and TRP2.
Plathymenin Description
Source: The herbs of Spatholobus suberectus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
5,6,7,3',4'-Pentamethoxyflavanone

Catalog No: CFN95394
CAS No: 104193-93-3
Price: $318/5mg
Platycodin J

Catalog No: CFN95395
CAS No: 1325614-80-9
Price: $318/5mg
Kaempferol 3-O-beta-(6''-p-coumaro...

Catalog No: CFN95089
CAS No: 111957-48-3
Price: $338/10mg
2''-O-Galloylmyricitrin

Catalog No: CFN95046
CAS No: 56939-52-7
Price: $333/5mg
Vicinin 2

Catalog No: CFN95249
CAS No: 90456-53-4
Price: $368/5mg
Gynosaponin TN2

Catalog No: CFN95331
CAS No: 77658-95-8
Price: $318/5mg
Epimedin K

Catalog No: CFN95019
CAS No: 174286-13-6
Price: $288/5mg
Quasipanaxatriol

Catalog No: CFN95248
CAS No: 171903-78-9
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4692 mL 17.3461 mL 34.6921 mL 69.3842 mL 86.7303 mL
5 mM 0.6938 mL 3.4692 mL 6.9384 mL 13.8768 mL 17.3461 mL
10 mM 0.3469 mL 1.7346 mL 3.4692 mL 6.9384 mL 8.673 mL
50 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.3877 mL 1.7346 mL
100 mM 0.0347 mL 0.1735 mL 0.3469 mL 0.6938 mL 0.8673 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Int Immunopharmacol. 2015 Mar;25(1):189-98.
Anti-inflammatory activity of flavonoids in Nepalese propolis is attributed to inhibition of the IL-33 signaling pathway.[Pubmed: 25614224 ]
Propolis has been used in folk medicine to improve health and prevent inflammatory diseases; however, the components that exhibit its anti-inflammatory activity remain unknown. We herein investigated the effects of flavonoids isolated from Nepalese propolis on the IL-33 signaling pathway to clarify the anti-inflammatory mechanism involved.
METHODS AND RESULTS:
Of the 8 types of flavonoids isolated from Nepalese propolis, 4 types of compounds, such as 3',4'-dihydroxy-4-methoxydalbergione, 4-methoxydalbergion, cearoin, and chrysin, markedly inhibited the IL-33-induced mRNA expression of inflammatory genes including IL-6, TNFα and IL-13 in bone marrow-derived mast cells (BMMC). These four flavonoids also inhibited the IL-33-induced activation of nuclear factor κB (NF-κB), which was consistent with their inhibitory effects on cytokine expression. The effects of these flavonoids are attributed to inhibition of IL-33-induced activation of IKK, which leads to the degradation of IκBα and nuclear localization of NF-κB. On the other hand, other flavonoids isolated from Nepalese propolis, such as isoliquiritigenin, Plathymenin, 7-hydroxyflavanone, and (+)-medicarpin, had no effect on the IL-33 signaling pathway or cytokine expression.
CONCLUSIONS:
Therefore, these results indicate that 3',4'-dihydroxy-4-methoxydalbergione, 4-methoxydalbergion, cearoin, and chrysin are the substances responsible for the anti-inflammatory activity of Nepalese propolis.
Stevioside

Catalog No: CFN99548
CAS No: 57817-89-7
Price: $40/20mg
N1,N10-Bis(p-coumaroyl)spermidine

Catalog No: CFN99248
CAS No: 114916-05-1
Price: $ /
Guaiol

Catalog No: CFN96326
CAS No: 489-86-1
Price: $ / mg
2-Amino-3-carboxy-1,4-naphthoquinone

Catalog No: CFN91040
CAS No: 173043-38-4
Price: $388/5mg
Protodioscin

Catalog No: CFN99517
CAS No: 55056-80-9
Price: $50/20mg
Momordicoside K

Catalog No: CFN92305
CAS No: 81348-84-7
Price: $ / mg
24-Methylenecycloartan-3-ol

Catalog No: CFN99496
CAS No: 1449-09-8
Price: $ /
Ganoderic acid D

Catalog No: CFN90292
CAS No: 108340-60-9
Price: $338/20mg
Mangiferin

Catalog No: CFN98719
CAS No: 4773-96-0
Price: $40/20mg
Corynoxeine

Catalog No: CFN98154
CAS No: 630-94-4
Price: $148/20mg
Tags: buy Plathymenin | Plathymenin supplier | purchase Plathymenin | Plathymenin cost | Plathymenin manufacturer | order Plathymenin | Plathymenin distributor