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Plumieride
Plumieride
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Plumieride
Price:
CAS No.: 511-89-7
Catalog No.: CFN98815
Molecular Formula: C21H26O12
Molecular Weight: 470.4 g/mol
Purity: >=98%
Type of Compound: Iridoids
Physical Desc.: Powder
Source: The herbs of Himatanthus fallax.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
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Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Plumieride has plant growth inhibiting properties, it shows strong fungitoxicity against some dermatophytes causing dermatomycosis to animals and human beings. Plumieride also has antioxidant , and immunomodulatory activities.
Targets: Immunology & Inflammation related
In vitro:
J Org Chem. 2004 Sep 17;69(19):6165-72.
Structural modifications of plumieride isolated from Plumeria bicolor and the effect of these modifications on in vitro anticancer activity.[Pubmed: 15357574]
Plumieride was isolated as one of the major components from the biologically active methanolic extract of the bark of Plumeria bicolor (family Apocynaceae). For investigating the effect of substituents on cytotoxic activity it was modified into a series of compounds.
METHODS AND RESULTS:
Replacing the methyl ester functionality of Plumieride with alkyl amides of variable carbon units improved the cytotoxic activity, and a correlation between overall lipophilicity and cytotoxic activity was observed. In Plumieride, the glucose moiety was converted into a di- and trisaccharide by following the protection and deprotection approach, and the resulting compounds produced enhanced cytotoxicity. However, these compounds were found to be less effective than plumeiride containing a dodecyl (12 carbon units) amide group.
CONCLUSIONS:
Among all of the derivatives, the naturally occurring Plumieride showed the least cytotoxicity (50% cell kill = 49.5 microg/mL), and the dodecyl amide analogue of Plumieridepentaacetate produced the best efficacy (50% cell kill = 11.8 microg/mL). The di- and trisaccharide analogues were found to be slightly less effective than the dodecyl derivative (50% cell kill = 15-17 microg/mL). The in vitro cytotoxicity of the Plumieride analogues was determined in radiation-induced fibrosarcoma (RIF) tumor cells.
Phytother Res. 2002 Jun;16(4):393-4.
Plumieride from Allamanda cathartica as an antidermatophytic agent.[Pubmed: 12112301 ]

METHODS AND RESULTS:
Plumieride has been isolated as an active principle of the leaves of Allamanda cathartica. It showed strong fungitoxicity against some dermatophytes causing dermatomycosis to animals and human beings. It exhibited a noncytotoxic nature against a P(388) mouse leukaemia cell line.
Phytochemistry, 1979, 18(8):1399-400.
Plant growth inhibiting properties of plumieride from Plumeria obtusifolia.[Reference: WebLink]

METHODS AND RESULTS:
Plant growth inhibiting properties of Plumieride from Plumeria obtusifolia.
J&k State Science Congress, University of Jammu, Jammu. 2005.
Immunomodulatory activity of Plumieride, an iridoid glucoside from Plumieria acutifolia leaves.[Reference: WebLink]

METHODS AND RESULTS:
Immunomodulatory activity of Plumieride, an iridoid glucoside from Plumieria acutifolia leaves.
Plumieride Description
Source: The herbs of Himatanthus fallax.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

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doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
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PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
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IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1259 mL 10.6293 mL 21.2585 mL 42.517 mL 53.1463 mL
5 mM 0.4252 mL 2.1259 mL 4.2517 mL 8.5034 mL 10.6293 mL
10 mM 0.2126 mL 1.0629 mL 2.1259 mL 4.2517 mL 5.3146 mL
50 mM 0.0425 mL 0.2126 mL 0.4252 mL 0.8503 mL 1.0629 mL
100 mM 0.0213 mL 0.1063 mL 0.2126 mL 0.4252 mL 0.5315 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Animal Research:
Phytomedicine. 2004 Feb;11(2-3):169-74.
Effects of plumieride, an iridoid on spermatogenesis in male albino rats.[Pubmed: 15070168 ]

METHODS AND RESULTS:
Oral feeding of male rats with Plumieride (15 mg/rat/day) for the period of 60 days did not cause any significant change in the body weight of treated rats. However, the weights of testes, epididymides, seminal vesicle and ventral prostate were significantly reduced when compared to control values. The production of step-19 spermatids was reduced by 87.26% in Plumieride treated rats. The population of preleptotene and pachytene spermatocytes were decreased by 64.26% and 55.13% respectively. Spermatogonia and sertoli cell population was also affected. Plumieride treatment resulted in an arrest of spermatogenesis without any systemic side effect. Sperm motility as well as sperm density was reduced significantly. The number of mature Leydig cells was decreased and complete suppression of fertility was observed. A significant fall in the protein and sialic acid contents of the testes, epididymides, seminal vesicle and ventral prostate as well as glycogen content of testes was also noticed. Fructose in seminal vesicle was lowered whereas testicular cholesterol was elevated. There was no significant change in RBC and WBC count, haemoglobin, haematocrit and sugar in the whole blood and total protein, cholesterol, phospholipid and triglycerides in the serum.
CONCLUSIONS:
Plumieride administration arrests spermatogenesis in male rats without noticeable side effects. For the clinical use more experiments should be carried out in a phased programme.
Antioxidants (Basel). 2014 Nov 27;3(4):798-813.
Antioxidant Potential of Plumieride against CCl₄-Induced Peroxidative Damage in Rats.[Pubmed: 26785241]
In search of a new potent as an antioxidant from natural sources, Plumieride-an iridoid isolated from the methanol extract of the bark of Plumeria bicolor (family Apocynaceae) was evaluated for its antioxidant potential against CCl₄-induced peroxidative damage in liver of rats.
METHODS AND RESULTS:
The antioxidant potential was evaluated by using hepatic tissue for SOD (superoxide dismutase), CAT (catalase), GSH (reduced glutathione), GPx (glutathione peroxidase), GR (glutathione reductase) and LPO (lipid peroxidation) alongwith the concomitant blood serum for AST & ALT (aspartate and alanine transaminases), GGT (gamma glutamyl transpeptidase), ALP (alkaline phosphatase), total bilirubin and total protein contents. All the biochemical parameters were significantly (p ≤ 0.001) altered by CCl₄ (0.3 mL/kg body weight/twice a week, intra-peritoneally for 30 days). Simultaneously, oral treatment with Plumieride (5, 10 and 20 mg/kg body weight/day for 30 days), restored all the parameters towards a normal level, remarkably. The histological findings of liver sections further corroborated the antioxidant potential of Plumieride compared with standard drug-silymarin.
CONCLUSIONS:
In conclusion, Plumieride consists of sugar molecules, which have alcoholic groups. Therefore, the alcoholic groups of sugar increase its antioxidant potential through intermolecular hydrogen bonding along with the thiol(SH) group of non-protein thiols and enzymes resulting in the restoration of the antioxidant system. Therefore, it might be considered a natural antioxidant against peroxidative damage in rats.
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